Now, in a study appearing in the March Molecular and Cellular Proteomics, researchers at Case Western Reserve University and Albert Einstein College of Medicine have identified some of the molecular changes that accompany the onset of diabetes-induced ED, which may lead to markers that will help identify ED risk as well as new potential drug targets.
Mark Chance and colleagues used a proteomics approach to examine the relative abundance of proteins in the corpora (the expandable tissues along the length of the penis which fill with blood during erection) of diabetic rats at two different stages of progression: one week and two months after the onset of diabetes. By comparing these rats to healthy age-matched controls, they identified 57 proteins in the penile tissue that either increased or decreased during diabetes.
The candidate proteins revealed insights into the mechanics of ED; perhaps not surprisingly, collagen proteins that provide strength and stiffness were down-regulated in diabetes, as were proteins that transport sex hormones. Meanwhile, proteins involved in cell death (apoptosis) were up-regulated, as were many proteins related to fat metabolism, changes that might be related to narrowing or hardening of blood vessels.
Chance and colleagues note that the rat model they used in the study mimics many relevant features of human ED, and thus the identification of these 57 candidate proteins could open up further and more detailed studies into the relationship between diabetes and ED in humans, and also lead to diagnostic and drug targets.
From the article: "Molecular Targets for Diabetes Mellitus-associated Erectile Dysfunction" by Elizabeth Yohannes, Jinsook Chang, Moses T. Tar, Kelvin P. Davies, and Mark R. Chance
Corresponding Author: Mark Chance, Center for Proteomics and Bioinformatics, Case Western Reserve University, Cleveland, OH; Tel.: 216-368-1490; Fax: 216-368-3812; E-mail: email@example.com
Article Link: http://mcponline.org/content/9/3/565.full
Nick Zagorski | EurekAlert!
Cells communicate in a dynamic code
19.02.2018 | California Institute of Technology
Studying mitosis' structure to understand the inside of cancer cells
19.02.2018 | Biophysical Society
For the first time, a team of researchers at the Max-Planck Institute (MPI) for Polymer Research in Mainz, Germany, has succeeded in making an integrated circuit (IC) from just a monolayer of a semiconducting polymer via a bottom-up, self-assembly approach.
In the self-assembly process, the semiconducting polymer arranges itself into an ordered monolayer in a transistor. The transistors are binary switches used...
Breakthrough provides a new concept of the design of molecular motors, sensors and electricity generators at nanoscale
Researchers from the Institute of Organic Chemistry and Biochemistry of the CAS (IOCB Prague), Institute of Physics of the CAS (IP CAS) and Palacký University...
For photographers and scientists, lenses are lifesavers. They reflect and refract light, making possible the imaging systems that drive discovery through the microscope and preserve history through cameras.
But today's glass-based lenses are bulky and resist miniaturization. Next-generation technologies, such as ultrathin cameras or tiny microscopes, require...
Scientists from the University of Zurich have succeeded for the first time in tracking individual stem cells and their neuronal progeny over months within the intact adult brain. This study sheds light on how new neurons are produced throughout life.
The generation of new nerve cells was once thought to taper off at the end of embryonic development. However, recent research has shown that the adult brain...
Theoretical physicists propose to use negative interference to control heat flow in quantum devices. Study published in Physical Review Letters
Quantum computer parts are sensitive and need to be cooled to very low temperatures. Their tiny size makes them particularly susceptible to a temperature...
15.02.2018 | Event News
13.02.2018 | Event News
12.02.2018 | Event News
19.02.2018 | Materials Sciences
19.02.2018 | Materials Sciences
19.02.2018 | Life Sciences