Their report on the new NOSH-aspirin, so named because it releases nitric oxide (NO) and hydrogen sulfide (H2S), appears in the journal ACS Medicinal Chemistry Letters.
Khosrow Kashfi, Ravinder Kodela and Mitali Chattopadhyay point out that NO and H2S are signaling substances produced in the body that relax blood vessels, reduce inflammation and have a variety of other effects. Scientists previously developed designer aspirin that releases NO in an effort to reduce aspirin’s potential adverse effects in causing bleeding in the gastrointestinal tract. Another designer aspirin that releases H2S was developed which also has anti-inflammatory properties and appears safe to the stomach.
Since NO and H2S are gases with physiological relevance, and Kashfi’s group had previously shown beneficial effects with both NO- and H2S-aspirins, they postulated that a new hybrid that incorporated both of these entities might be even more potent and effective than either one alone. Their hypothesis has proved to be correct.
They found indications that the new hybrid inhibits the growth of breast, colon, pancreas, lung, prostate and some leukemia cancer cells in laboratory tests. Some of the NOSH-aspirins tested were more than 100,000 times more powerful against cancer cell growth than aspirin alone. Promisingly, the group reported that their hybrids did not damage normal cells.
The authors acknowledge funding from the National Cancer Institute.
Michael Woods | Newswise Science News
Scientists enlist engineered protein to battle the MERS virus
22.05.2017 | University of Toronto
Insight into enzyme's 3-D structure could cut biofuel costs
19.05.2017 | DOE/Los Alamos National Laboratory
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For the first time, scientists have succeeded in studying the strength of hydrogen bonds in a single molecule using an atomic force microscope. Researchers from the University of Basel’s Swiss Nanoscience Institute network have reported the results in the journal Science Advances.
Hydrogen is the most common element in the universe and is an integral part of almost all organic compounds. Molecules and sections of macromolecules are...
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