Human neural stem cells restore motor function in mice with chronic spinal cord injury

A UC Irvine study is the first to demonstrate that human neural stem cells can restore mobility in cases of chronic spinal cord injury, suggesting the prospect of treating a much broader population of patients.

Previous breakthrough stem cell studies have focused on the acute, or early, phase of spinal cord injury, a period of up to a few weeks after the initial trauma when drug treatments can lead to some functional recovery.

The UCI study, led by Aileen Anderson and Brian Cummings of the Sue and Bill Gross Stem Cell Research Center, is significant because the therapy can restore mobility during the later chronic phase, the period after spinal cord injury in which inflammation has stabilized and recovery has reached a plateau. There are no drug treatments to help restore function in such cases.

The study appears in the open-access, peer-reviewed journal PLoS ONE and is available online.

The Anderson-Cummings team transplanted human neural stem cells into mice 30 days after a spinal cord injury caused hind-limb paralysis. The cells then differentiated into neural tissue cells, such as oligodendrocytes and early neurons, and migrated to spinal cord injury sites. Three months after initial treatment, the mice demonstrated significant and persistent recovery of walking ability in two separate tests of motor function when compared to control groups.

“Human neural stem cells are a novel therapeutic approach that holds much promise for spinal cord injury,” said Anderson, associate professor of physical medicine & rehabilitation and anatomy & neurobiology at UCI. “This study builds on the extensive work we previously published in the acute phase of injury and offers additional hope to those who are paralyzed or have impaired motor function.”

“About 1.3 million individuals in the U.S. are living with chronic spinal cord injury,” added Cummings, associate professor of physical medicine & rehabilitation and anatomy & neurobiology. “This latest study provides additional evidence that human neural stem cells may be a viable treatment approach for them.”

The research is the latest in a series of collaborative studies conducted since 2002 with StemCells Inc. that have focused on the use of StemCells’ human neural stem cells in spinal cord injury and resulted in multiple co-authored publications. StemCells Inc., based in Palo Alto, Calif., is engaged in the research, development and commercialization of stem cell therapeutics and tools for use in stem cell-based research and drug discovery.

According to Dr. Stephen Huhn, vice president and head of the central nervous system program at StemCells Inc., “the strong preclinical data we have accumulated to date will enable our transition to a clinical trial, which we plan to initiate in 2011.”

Desirée Salazar of UC San Diego, Nobuko Uchida of StemCells Inc. and Frank P.T. Hamers of the Tolbrug Rehabilitation Centre in ’s-Hertogenbosch, Netherlands, also contributed to the study, which received National Institutes of Health and California Institute for Regenerative Medicine support.

About the Sue and Bill Gross Stem Cell Research Center: Promoting basic and clinical research and training in the field of stem cell biology at UC Irvine, the center is a leading international institution in stem cell research and clinical applications. It consolidates existing research strengths and clinical initiatives at UCI and serves as a nucleus for growth via collaboration and new recruits. The center provides an organizational structure for all areas of stem cell research, supports premier graduate training, maintains a core stem cell facility and equipment, hosts guest researchers and annual meetings, and contributes to research and dialogue on policy and ethical issues related to stem cells. For more information, visit http://stemcell.uci.edu.

About the University of California, Irvine: Founded in 1965, UCI is a top-ranked university dedicated to research, scholarship and community service. Led by Chancellor Michael Drake since 2005, UCI is among the most dynamic campuses in the University of California system, with nearly 28,000 undergraduate and graduate students, 1,100 faculty and 9,000 staff. Orange County’s largest employer, UCI contributes an annual economic impact of $3.9 billion. For more UCI news, visit www.today.uci.edu.

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