HZI scientists develop model for dynamic mitochondrial networks
Mitochondria are the power plants of cells. They control the production of energy and initiate various central cellular processes. If they become non-functional, this can cause or favour a number of diseases. These diseases are mainly of a neurological or muscular type, but include ageing processes as well.
Systems biologists at the Helmholtz Centre for Infection Research (HZI) in Braunschweig used a new mathematical model to describe which mechanisms are involved in the formation and maintenance of the dynamic mitochondrial networks in cells. The scientists published their results in "Scientific Reports".
One special feature of mitochondria is their pronounced dynamic behaviour inside the cell. They form a network that changes on a time scale of minutes through fission and fusion with other mitochondria again. Their special structure has a significant influence on how effectively they can supply energy:
Fibrous network structures produce a large amount of energy, whereas smaller fragments are less effective. "These processes play a role in cell ageing as well. Over-stressed or damaged mitochondria get fragmented and are then subjected to disposal," says Valerii Sukhorukov, who is a scientist at the Systems Immunology department at the HZI and the principal author of the study.
But how does the dynamic balance between the small fragments and the effective fibres of mitochondria get established? This was the central question addressed by the researchers. "Mechanisms of this type cannot be studied by biochemical analyses alone. This requires model-based simulations on a computer that explain the dynamic changes in the cell very well," says Prof Michael Meyer-Hermann, who directs the Systems Immunology department.
For this purpose, the scientists developed an initial mathematical model that is based on the different lengths of the mitochondrial fragments in linear or branched arrangement. The central result of the study is that an exact description of the mitochondria in the cell becomes possible only if the random motions of mitochondria along the fibres of the cellular skeleton, called microtubules, are taken into account.
This resulted in a so-called graph model that is based on the density of the microtubules and their intersections within the cell. The model describes all forms of mitochondria that have been found in experiments thus far and it also yields explanations for events that were understood incompletely thus far.
Sukhorukov and his colleagues would like to use the new mathematical model in the future to analyse the quality control of the fragmented mitochondria and to understand how cells control or remedy damage to their mitochondria. "This is very important to understand how cells control their energy balance despite the accumulation of damage with advancing age. This would allow us to draw conclusions about certain genetics-related diseases such as Parkinson's and ageing processes in the immune system," says Sukhorukov.
Valerii M. Sukhorukov, Michael Meyer-Hermann. Structural Heterogeneity of the Mitochondria Induced by the Microtubule Cytoskeleton.Scientific Reports. 2015 Sep 11. 5:13924. DOI: 10.1038/srep13924
http://www.helmholtz-hzi.de/en/news_events/news/view/article/complete/how_the_po... - This press release at helmholtz-hzi.de
http://dx.doi.org/10.1038/srep13924 - Link to the original publication
Susanne Thiele | Helmholtz-Zentrum für Infektionsforschung
First time-lapse footage of cell activity during limb regeneration
25.10.2016 | eLife
Phenotype at the push of a button
25.10.2016 | Institut für Pflanzenbiochemie
Terahertz excitation of selected crystal vibrations leads to an effective magnetic field that drives coherent spin motion
Controlling functional properties by light is one of the grand goals in modern condensed matter physics and materials science. A new study now demonstrates how...
Researchers from the Institute for Quantum Computing (IQC) at the University of Waterloo led the development of a new extensible wiring technique capable of controlling superconducting quantum bits, representing a significant step towards to the realization of a scalable quantum computer.
"The quantum socket is a wiring method that uses three-dimensional wires based on spring-loaded pins to address individual qubits," said Jeremy Béjanin, a PhD...
In a paper in Scientific Reports, a research team at Worcester Polytechnic Institute describes a novel light-activated phenomenon that could become the basis for applications as diverse as microscopic robotic grippers and more efficient solar cells.
A research team at Worcester Polytechnic Institute (WPI) has developed a revolutionary, light-activated semiconductor nanocomposite material that can be used...
By forcefully embedding two silicon atoms in a diamond matrix, Sandia researchers have demonstrated for the first time on a single chip all the components needed to create a quantum bridge to link quantum computers together.
"People have already built small quantum computers," says Sandia researcher Ryan Camacho. "Maybe the first useful one won't be a single giant quantum computer...
COMPAMED has become the leading international marketplace for suppliers of medical manufacturing. The trade fair, which takes place every November and is co-located to MEDICA in Dusseldorf, has been steadily growing over the past years and shows that medical technology remains a rapidly growing market.
In 2016, the joint pavilion by the IVAM Microtechnology Network, the Product Market “High-tech for Medical Devices”, will be located in Hall 8a again and will...
14.10.2016 | Event News
14.10.2016 | Event News
12.10.2016 | Event News
25.10.2016 | Earth Sciences
25.10.2016 | Physics and Astronomy
25.10.2016 | Life Sciences