We are surrounded by bacteria, viruses, fungi and parasites. The fact that we nevertheless do not fall prey to infections is thanks to certain cellular sensor molecules such as toll-like receptors (TLR), which recognize the molecular structure of pathogens and intercede by ensuring an often completely unnoticeable elimination of the invaders.
A bacterial 23S ribososmal (r) RNA segment activates the Toll-like receptor 13. This 23S rRNA segment is known to also bind antibiotics such as erythromycin (ery). Its central adenosine (A) 2085 in S. aureus and A2058 in E. coli 23S rRNA is mutated or methylated in ery resistant bacteria.
Design: Daniela Willemsen
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