Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

How hosts recognize bacteria

20.07.2012
Outstanding publication in Science Magazine

We are surrounded by bacteria, viruses, fungi and parasites. The fact that we nevertheless do not fall prey to infections is thanks to certain cellular sensor molecules such as toll-like receptors (TLR), which recognize the molecular structure of pathogens and intercede by ensuring an often completely unnoticeable elimination of the invaders.


A bacterial 23S ribososmal (r) RNA segment activates the Toll-like receptor 13. This 23S rRNA segment is known to also bind antibiotics such as erythromycin (ery). Its central adenosine (A) 2085 in S. aureus and A2058 in E. coli 23S rRNA is mutated or methylated in ery resistant bacteria.
Design: Daniela Willemsen

Their immune-activating abilities were only detected in 1998, a discovery which was awarded with the Nobel Prize. Now, there are new findings published by an international Team of microbiologists in the research journal Science.

The international research team led by Prof. Dr. Carsten Kirschning of the Institute of Medical Microbiology at the University hospital Essen and the University of Duisburg-Essen and PD Dr. Hubertus Hochrein is examining the complex recognition of bacteria.

Our innate immune system is clever. Certain structures, which are characteristic of many microorganisms are recognized via TLR which trigger the necessary inflammatory response. However, the situation can become dangerous: since this receptor system is so sensitive, the immune response to serious infections may be over-exaggerated and miss the mark. Blood poisoning and frequently septic shock is the result.

Thus, the experts decided to take a closer look at the host recognition of Staphylococcus and E.coli bacteria, often the main agents of blood poisoning. They established that in the cell, TLR13 recognises the segment of bacterial ribosomal ribonucleic acid to which specific antibiotics such as Erythromycin also bind should the segment not have been altered by mutation or other modifications. The concrete ribonucleic acid is referred as 23S rRNA. Animal and human ribosomes do not bind Erythromycin to their own 28S rRNA because its structure resembles that of the 23S rRNA of resistant bacteria.

The new findings are significant for the treatment of bacterial infections and gaining a greater understanding of antibiotic resistance. In addition, these findings may be of help in the therapy of immunological overreactions and lead to new vaccination strategies.

The study was conducted by an international research team led by Prof. Dr. Carsten Kirschning of the Institute of Medical Microbiology at the University hospital, University of Duisburg-Essen, PD Dr. Hubertus Hochrein of Bavarian Nordic in Martinsried, Prof. Dr. Stefan Bauer of the Institute of Immunology at the Philipps University of Marburg and Prof. Dr. Hermann Wagner of the Institute of Medical Microbiology, Immunology and Hygiene at the Technical University of Munich. Further collaborating scientists came from Munich, Switzerland and Japan.

Publication: „TLR13 Recognizes Bacterial 23S rRNA Devoid of Erythromycin Resistance-Forming Modification.“ (Science Express)

Further information:
http://www.sciencemag.org/
● Prof. Dr. Carsten Kirschning, Tel: +49 201/723-1824, Cell: +49 1609/254-7309, carsten.kirschning@uk-essen.de
● Press officer of the University hospital Essen: Christine Harrell, Tel. +49 201/723-3107, christine.harrell@uk-essen.de

Editing: Carmen Tomlik, Tel. +49 203/379-1489
Translation: Delia Cosgrove, Tel. +49 201/723-4257, delia.cosgrove@uni-due.de

Beate Kostka | Universität Duisburg-Essen
Further information:
http://www.uni-due.de
http://www.sciencemag.org/

More articles from Life Sciences:

nachricht Link Discovered between Immune System, Brain Structure and Memory
26.04.2017 | Universität Basel

nachricht Researchers develop eco-friendly, 4-in-1 catalyst
25.04.2017 | Brown University

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Making lightweight construction suitable for series production

More and more automobile companies are focusing on body parts made of carbon fiber reinforced plastics (CFRP). However, manufacturing and repair costs must be further reduced in order to make CFRP more economical in use. Together with the Volkswagen AG and five other partners in the project HolQueSt 3D, the Laser Zentrum Hannover e.V. (LZH) has developed laser processes for the automatic trimming, drilling and repair of three-dimensional components.

Automated manufacturing processes are the basis for ultimately establishing the series production of CFRP components. In the project HolQueSt 3D, the LZH has...

Im Focus: Wonder material? Novel nanotube structure strengthens thin films for flexible electronics

Reflecting the structure of composites found in nature and the ancient world, researchers at the University of Illinois at Urbana-Champaign have synthesized thin carbon nanotube (CNT) textiles that exhibit both high electrical conductivity and a level of toughness that is about fifty times higher than copper films, currently used in electronics.

"The structural robustness of thin metal films has significant importance for the reliable operation of smart skin and flexible electronics including...

Im Focus: Deep inside Galaxy M87

The nearby, giant radio galaxy M87 hosts a supermassive black hole (BH) and is well-known for its bright jet dominating the spectrum over ten orders of magnitude in frequency. Due to its proximity, jet prominence, and the large black hole mass, M87 is the best laboratory for investigating the formation, acceleration, and collimation of relativistic jets. A research team led by Silke Britzen from the Max Planck Institute for Radio Astronomy in Bonn, Germany, has found strong indication for turbulent processes connecting the accretion disk and the jet of that galaxy providing insights into the longstanding problem of the origin of astrophysical jets.

Supermassive black holes form some of the most enigmatic phenomena in astrophysics. Their enormous energy output is supposed to be generated by the...

Im Focus: A Quantum Low Pass for Photons

Physicists in Garching observe novel quantum effect that limits the number of emitted photons.

The probability to find a certain number of photons inside a laser pulse usually corresponds to a classical distribution of independent events, the so-called...

Im Focus: Microprocessors based on a layer of just three atoms

Microprocessors based on atomically thin materials hold the promise of the evolution of traditional processors as well as new applications in the field of flexible electronics. Now, a TU Wien research team led by Thomas Müller has made a breakthrough in this field as part of an ongoing research project.

Two-dimensional materials, or 2D materials for short, are extremely versatile, although – or often more precisely because – they are made up of just one or a...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

Expert meeting “Health Business Connect” will connect international medical technology companies

20.04.2017 | Event News

Wenn der Computer das Gehirn austrickst

18.04.2017 | Event News

7th International Conference on Crystalline Silicon Photovoltaics in Freiburg on April 3-5, 2017

03.04.2017 | Event News

 
Latest News

Scientist invents way to trigger artificial photosynthesis to clean air

26.04.2017 | Materials Sciences

Ammonium nitrogen input increases the synthesis of anticarcinogenic compounds in broccoli

26.04.2017 | Agricultural and Forestry Science

SwRI-led team discovers lull in Mars' giant impact history

26.04.2017 | Physics and Astronomy

VideoLinks
B2B-VideoLinks
More VideoLinks >>>