Researchers at the Hebrew University of Jerusalem and other institutions have identified two distinguishable groups of genes: those that produce very abundant biochemical products in the cell and function properly in the majority of biological processes, and a flexible subset that might have abnormal function in a disease.
They demonstrated that these two groups can be found among various organisms and cell types, including stem cells and cancer cells.
One set of genes is a robust network that conducts the basic functions of all cells, such as producing energy and biochemical building blocks. This group represents the “hard core” of different organisms.
The biochemical products produced by the other group of genes are less abundant in organisms, and their amount might vary significantly between different types of normal and diseased cells and even between different cancer cells derived from patients with the same type of cancer.
This dramatic variation between patients with the same disease has clear implications for personalized medicine. It implies that detailed analysis of each patient will be required in order to determine the exact type of patient-oriented therapy needed.The work on defining the two gene sets was described in a recent article in the Proceedings of the National Academy of Sciences in the US. The authors were Dr.Nataly Kravchenko-Balasha, a former graduate student at the Silberman Institute of life sciences at the Hebrew University and currently a post-doctoral fellow at the California Institute of Technology in Pasadena; Prof.Alexander Levitzki, who was Kravchenko-Balahsha’s Ph.D. advisor; Prof. Raphael D. Levine from the Fritz Haber Research Institute for Molecular Dynamics at the Hebrew University; and colleagues from three other institutes: Prof.Varda Rotter (Weizmann Institute of Science), Prof. Francoise Remacle (Université de Liège), and Dr. Andrew Goldstein (University of California, Los Angeles); plus Dr. Ayelet Gross (the Hebrew University).
Jerry Barach | Hebrew University
Study identifies RNA molecule that shields breast cancer stem cells from immune system
23.05.2017 | Princeton University
“Pregnant” Housefly Males Demonstrate the Evolution of Sex Determination
23.05.2017 | Universität Zürich
An international team of physicists has monitored the scattering behaviour of electrons in a non-conducting material in real-time. Their insights could be beneficial for radiotherapy.
We can refer to electrons in non-conducting materials as ‘sluggish’. Typically, they remain fixed in a location, deep inside an atomic composite. It is hence...
Two-dimensional magnetic structures are regarded as a promising material for new types of data storage, since the magnetic properties of individual molecular building blocks can be investigated and modified. For the first time, researchers have now produced a wafer-thin ferrimagnet, in which molecules with different magnetic centers arrange themselves on a gold surface to form a checkerboard pattern. Scientists at the Swiss Nanoscience Institute at the University of Basel and the Paul Scherrer Institute published their findings in the journal Nature Communications.
Ferrimagnets are composed of two centers which are magnetized at different strengths and point in opposing directions. Two-dimensional, quasi-flat ferrimagnets...
An Australian-Chinese research team has created the world's thinnest hologram, paving the way towards the integration of 3D holography into everyday...
In the race to produce a quantum computer, a number of projects are seeking a way to create quantum bits -- or qubits -- that are stable, meaning they are not much affected by changes in their environment. This normally needs highly nonlinear non-dissipative elements capable of functioning at very low temperatures.
In pursuit of this goal, researchers at EPFL's Laboratory of Photonics and Quantum Measurements LPQM (STI/SB), have investigated a nonlinear graphene-based...
Dental plaque and the viscous brown slime in drainpipes are two familiar examples of bacterial biofilms. Removing such bacterial depositions from surfaces is...
23.05.2017 | Event News
22.05.2017 | Event News
17.05.2017 | Event News
23.05.2017 | Earth Sciences
23.05.2017 | Life Sciences
23.05.2017 | Physics and Astronomy