Stressors such as job, marital and financial problems have been linked to the increased risk for developing cardiovascular disease including heart attack. But there hasn't been a biological marker to measure chronic stress.
Drs. Gideon Koren and Stan Van Uum developed a method to measure cortisol levels in hair providing an accurate assessment of stress levels in the months prior to an acute event such as a heart attack. The research is published on-line in the journal Stress.
Cortisol is considered to be a stress hormone. Its secretion is increased during times of stress. Traditionally it's been measured in serum, urine and saliva, but that only shows stress at the time of measurement, not over longer periods of time. Cortisol is also captured in the hair shaft.
"Intuitively we know stress is not good for you, but it's not easy to measure," explains Dr. Koren, who holds the Ivey Chair in Molecular Toxicology at Western's Schulich School of Medicine & Dentistry. "We know that on average, hair grows one centimetre (cm) a month, and so if we take a hair sample six cm long, we can determine stress levels for six months by measuring the cortisol level in the hair."
In the study, hair samples three cm long were collected from 56 male adults who were admitted to the Meir Medical Centre in Kfar-Saba, Israel suffering heart attacks. A control group, made up of 56 male patients who were hospitalized for reasons other than a heart attack, was also asked for hair samples. Higher hair cortisol levels corresponding to the previous three months were found in the heart attack patients compared to the control group.
The prevalence of diabetes, hypertension, smoking and family history of coronary artery disease did not differ significantly between the two groups, although the heart attack group had more cholesterol problems. After accounting for the known risk factors, hair cortisol content emerged as the strongest predictor of heart attack.
"Stress is a serious part of modern life affecting many areas of health and life," says Dr. Koren. "This study has implications for research and for practice, as stress can be managed with lifestyle changes and psychotherapy."
The study was supported by Physician Services Inc. and the Canadian Institutes of Health Research.
Kathy Wallis | EurekAlert!
Multi-institutional collaboration uncovers how molecular machines assemble
02.12.2016 | Salk Institute
Fertilized egg cells trigger and monitor loss of sperm’s epigenetic memory
02.12.2016 | IMBA - Institut für Molekulare Biotechnologie der Österreichischen Akademie der Wissenschaften GmbH
A multi-institutional research collaboration has created a novel approach for fabricating three-dimensional micro-optics through the shape-defined formation of porous silicon (PSi), with broad impacts in integrated optoelectronics, imaging, and photovoltaics.
Working with colleagues at Stanford and The Dow Chemical Company, researchers at the University of Illinois at Urbana-Champaign fabricated 3-D birefringent...
In experiments with magnetic atoms conducted at extremely low temperatures, scientists have demonstrated a unique phase of matter: The atoms form a new type of quantum liquid or quantum droplet state. These so called quantum droplets may preserve their form in absence of external confinement because of quantum effects. The joint team of experimental physicists from Innsbruck and theoretical physicists from Hannover report on their findings in the journal Physical Review X.
“Our Quantum droplets are in the gas phase but they still drop like a rock,” explains experimental physicist Francesca Ferlaino when talking about the...
The Max Planck Institute for Physics (MPP) is opening up a new research field. A workshop from November 21 - 22, 2016 will mark the start of activities for an innovative axion experiment. Axions are still only purely hypothetical particles. Their detection could solve two fundamental problems in particle physics: What dark matter consists of and why it has not yet been possible to directly observe a CP violation for the strong interaction.
The “MADMAX” project is the MPP’s commitment to axion research. Axions are so far only a theoretical prediction and are difficult to detect: on the one hand,...
Broadband rotational spectroscopy unravels structural reshaping of isolated molecules in the gas phase to accommodate water
In two recent publications in the Journal of Chemical Physics and in the Journal of Physical Chemistry Letters, researchers around Melanie Schnell from the Max...
The efficiency of power electronic systems is not solely dependent on electrical efficiency but also on weight, for example, in mobile systems. When the weight of relevant components and devices in airplanes, for instance, is reduced, fuel savings can be achieved and correspondingly greenhouse gas emissions decreased. New materials and components based on gallium nitride (GaN) can help to reduce weight and increase the efficiency. With these new materials, power electronic switches can be operated at higher switching frequency, resulting in higher power density and lower material costs.
Researchers at the Fraunhofer Institute for Solar Energy Systems ISE together with partners have investigated how these materials can be used to make power...
16.11.2016 | Event News
01.11.2016 | Event News
14.10.2016 | Event News
02.12.2016 | Medical Engineering
02.12.2016 | Agricultural and Forestry Science
02.12.2016 | Physics and Astronomy