Changes in the gut bacteria protect against stroke

The human body contains ten times more bacterial cells than human cells, most of which are found in the gut. These bacteria contain an enormous number of genes in addition to our host genome, and are collectively known as the gut metagenome.

Rapidly expanding field

How does the metagenome affect our health? This question is currently being addressed by researchers in the rapidly expanding field of metagenomic research. Several diseases have been linked to variations in the metagenome.

Researchers at Chalmers University of Technology and Sahlgrenska Academy, University of Gothenburg, now also show that changes in the gut metagenome can be linked to atherosclerosis and stroke.

Differences in gut microbiota

The researchers compared a group of stroke patients with a group of healthy subjects and found major differences in their gut microbiota. In particular, they showed that genes required for the production of carotenoids were more frequently found in gut microbiota from healthy subjects. The healthy subjects also had significantly higher levels of a certain carotenoid in the blood than the stroke survivors.

Affects disease states

Carotenoids are a type of antioxidant, and it has been claimed for many years that they protect against angina and stroke. Thus, the increased incidence of carotenoid-producing bacteria in the gut of healthy subjects may offer clues to explain how the gut metagenome affects disease states.

Carotenoids are marketed today as a dietary supplement. The market for them is huge, but clinical studies of their efficacy in protecting against angina and stroke have produced varying results.

Important health benefits

Jens Nielsen, Professor of Systems Biology at Chalmers, says that it may be preferable to take probiotics instead – for example dietary supplements containing types of bacteria that produce carotenoids.

“Our results indicate that long-term exposure to carotenoids, through production by the bacteria in the digestive system, has important health benefits. These results should make it possible to develop new probiotics. We think that the bacterial species in the probiotics would establish themselves as a permanent culture in the gut and have a long-term effect”.

Develop risk prognoses

“By examining the patient’s bacterial microbiota, we should also be able to develop risk prognoses for cardiovascular disease”, says Fredrik Bäckhed, Professor of Molecular Medicine at the University of Gothenburg,. ”It should be possible to provide completely new disease-prevention options”.

Close cooperation

The researchers have now started a company, Metabogen, to further develop their discoveries relating to the metagenome. Their success is based on close cooperation between engineers, microbiologists and doctors.

Jens Nielsen and Fredrik Bäckhed both agree that one of the challenges in the rapidly developing area of metagenomics is its multidisciplinary facets, requiring novel collaborations and merging of research fields.

The paper “Symptomatic atherosclerosis is associated with an altered gut metagenome” was published on December 4.

Contact:
Fredrik Bäckhed, Professor of Molecular Medicine at the Sahlgrenska Academy, University of Gothenburg, +46 31 342 78 33, fredrik.backhed@wlab.gu.se

Jens Nielsen, Professor of Systems Biology at Chalmers University of Technology, +46 70 243 66 18, nielsenj@chalmers.se

Fredrik Karlsson, research student in Systems Biology at Chalmers University of Technology, +46 31 772 38 86, fredrik.karlsson@chalmers.se

The research was funded by:
Knut and Alice Wallenberg Foundation, the Chalmers Foundation, Swedish Heart Lung Foundation, Torsten Söderberg’s Foundation, IngaBritt och Arne Lundbergs Foundation, AFA Insurances, the Swedish Research Council, and the Swedish Foundation for Strategic Research.