"The gut microbiota enhances the host's metabolic capacity for processing nutrients and drugs and modulates the activities of multiple pathways in a variety of organ systems," says Sandrine Claus of the Imperial College of London, a researcher on the study.
Claus and her colleagues exposed germ-free mice to bedding that had previously been used by conventional mice with normal microbiota and followed their metabolic profiles for 20 days to observe changes as they became colonized with gut bacteria.
Over the first 5 days after exposure, the mice exhibited a rapid increase in weight (4%). Colonization also triggered a number of processes in the liver in which sugars (glucose) are converted to starch (glycogen) and fat (triglycerides) for short-term and long-term energy storage. Statistical modeling between liver metabolic functions and microbial populations determined that the levels of glucose, glycogen and triglycerides in the liver were strongly associated with a single family of bacteria called Coriobacteriaceae.
"Here we describe the first evidence of an in vivo association between a family of bacteria and hepatic lipid metabolism. These results provide new insights into the fundamental mechanisms that regulate host-gut microbiota interactions and are of wide interest to microbiological, nutrition, metabolic, systems biology and pharmaceutical research communities," says Claus.
Another important finding in the paper, according to Claus, is that gut colonization strongly stimulated the expression and activity of the cytochrome P450 3A11, an essential enzyme in drug-detoxification pathways.
Although she warns about being careful to extrapolate the specific findings from mice to humans, Claus notes the results of this research will provide a basis to further develop new strategies to beneficially modulate host metabolism by altering microbial communities in the gut.
mBio® is a new open access online journal published by the American Society for Microbiology to make microbiology research broadly accessible. The focus of the journal is on rapid publication of cutting-edge research spanning the entire spectrum of microbiology and related fields. It can be found online at http://mbio.asm.org.
Jim Sliwa | EurekAlert!
Meadows beat out shrubs when it comes to storing carbon
23.11.2017 | Norwegian University of Science and Technology
Migrating Cells: Folds in the cell membrane supply material for necessary blebs
23.11.2017 | Westfälische Wilhelms-Universität Münster
Heat from the friction of rocks caused by tidal forces could be the “engine” for the hydrothermal activity on Saturn's moon Enceladus. This presupposes that...
The WHO reports an estimated 429,000 malaria deaths each year. The disease mostly affects tropical and subtropical regions and in particular the African continent. The Fraunhofer Institute for Silicate Research ISC teamed up with the Fraunhofer Institute for Molecular Biology and Applied Ecology IME and the Institute of Tropical Medicine at the University of Tübingen for a new test method to detect malaria parasites in blood. The idea of the research project “NanoFRET” is to develop a highly sensitive and reliable rapid diagnostic test so that patient treatment can begin as early as possible.
Malaria is caused by parasites transmitted by mosquito bite. The most dangerous form of malaria is malaria tropica. Left untreated, it is fatal in most cases....
The formation of stars in distant galaxies is still largely unexplored. For the first time, astron-omers at the University of Geneva have now been able to closely observe a star system six billion light-years away. In doing so, they are confirming earlier simulations made by the University of Zurich. One special effect is made possible by the multiple reflections of images that run through the cosmos like a snake.
Today, astronomers have a pretty accurate idea of how stars were formed in the recent cosmic past. But do these laws also apply to older galaxies? For around a...
Just because someone is smart and well-motivated doesn't mean he or she can learn the visual skills needed to excel at tasks like matching fingerprints, interpreting medical X-rays, keeping track of aircraft on radar displays or forensic face matching.
That is the implication of a new study which shows for the first time that there is a broad range of differences in people's visual ability and that these...
Computer Tomography (CT) is a standard procedure in hospitals, but so far, the technology has not been suitable for imaging extremely small objects. In PNAS, a team from the Technical University of Munich (TUM) describes a Nano-CT device that creates three-dimensional x-ray images at resolutions up to 100 nanometers. The first test application: Together with colleagues from the University of Kassel and Helmholtz-Zentrum Geesthacht the researchers analyzed the locomotory system of a velvet worm.
During a CT analysis, the object under investigation is x-rayed and a detector measures the respective amount of radiation absorbed from various angles....
15.11.2017 | Event News
15.11.2017 | Event News
30.10.2017 | Event News
23.11.2017 | Information Technology
23.11.2017 | Physics and Astronomy
23.11.2017 | Life Sciences