Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Growth Hormone Not Beneficial for ALS

27.11.2008
A growth hormone that had shown some promise for treating people with amyotrophic lateral sclerosis (ALS) showed no benefit in a new study published in the November 25, 2008, issue of Neurology®, the medical journal of the American Academy of Neurology.

Two previous, shorter studies using growth hormone insulin-like growth factor-1, or IGF-1, to treat ALS had conflicting results. A North American study found that the drug was beneficial, while a European study found no benefit.

The current two-year study found that IGF-1 does not slow the progression of weakness in the disease. ALS, also called Lou Gehrig’s disease, is a progressive, fatal neurodegenerative disease that causes muscles to weaken and eventually deteriorate.

“It’s disappointing that we were not able to confirm the benefit that was found in the North American study,” said study author Eric J. Sorenson, MD, of the Mayo Clinic in Rochester, MN, and a member of the American Academy of Neurology. “The current treatment options for ALS are inadequate, and more effective treatments are vitally needed.”

The study involved 330 people with ALS from 20 medical centers. Half were given injections of the growth hormone twice a day and half were given injections of a placebo. Researchers tested the participants’ muscle strength at the beginning of the study and again five times during the study period. Researchers also tracked how long participants went without needing a tracheostomy, or a tube inserted in the neck for help with breathing, and their scores in a test of how well they can perform daily activities.

There was no difference in muscle strength between those taking the growth hormone and those taking the placebo. There were also no differences in how long the two groups went without needing a tracheostomy or in their results on the daily activities test.

The study was supported by the National Institutes of Health and the ALS Association. The study drug and placebo were provided by Cephalon, Inc.

Additional audio and video resources, including excerpts from an interview with Dr. Sorenson describing the research, are available on the Mayo Clinic News Blog at: http://newsblog.mayoclinic.org/2008/11/18/als-growth-hormone-study/. These materials also are subject to embargo, but may be accessed in advance by journalists for incorporation into stories. Please contact the AAN Media and Public Relations Department for the password to this post.

The American Academy of Neurology, an association of more than 21,000 neurologists and neuroscience professionals, is dedicated to improving patient care through education and research. A neurologist is a doctor with specialized training in diagnosing, treating and managing disorders of the brain and nervous system such as epilepsy, dystonia, migraine, Huntington’s disease, and dementia. For more information about the American Academy of Neurology, visit http://www.aan.com/go/pressroom.

Rachel Seroka | American Academy of Neurology
Further information:
http://www.aan.com/press

More articles from Life Sciences:

nachricht Ageless ears? Elderly barn owls do not become hard of hearing
26.09.2017 | Carl von Ossietzky-Universität Oldenburg

nachricht eTRANSAFE – collaborative research project aimed at improving safety in drug development process
26.09.2017 | Fraunhofer-Gesellschaft

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: The fastest light-driven current source

Controlling electronic current is essential to modern electronics, as data and signals are transferred by streams of electrons which are controlled at high speed. Demands on transmission speeds are also increasing as technology develops. Scientists from the Chair of Laser Physics and the Chair of Applied Physics at Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU) have succeeded in switching on a current with a desired direction in graphene using a single laser pulse within a femtosecond ¬¬ – a femtosecond corresponds to the millionth part of a billionth of a second. This is more than a thousand times faster compared to the most efficient transistors today.

Graphene is up to the job

Im Focus: LaserTAB: More efficient and precise contacts thanks to human-robot collaboration

At the productronica trade fair in Munich this November, the Fraunhofer Institute for Laser Technology ILT will be presenting Laser-Based Tape-Automated Bonding, LaserTAB for short. The experts from Aachen will be demonstrating how new battery cells and power electronics can be micro-welded more efficiently and precisely than ever before thanks to new optics and robot support.

Fraunhofer ILT from Aachen relies on a clever combination of robotics and a laser scanner with new optics as well as process monitoring, which it has developed...

Im Focus: The pyrenoid is a carbon-fixing liquid droplet

Plants and algae use the enzyme Rubisco to fix carbon dioxide, removing it from the atmosphere and converting it into biomass. Algae have figured out a way to increase the efficiency of carbon fixation. They gather most of their Rubisco into a ball-shaped microcompartment called the pyrenoid, which they flood with a high local concentration of carbon dioxide. A team of scientists at Princeton University, the Carnegie Institution for Science, Stanford University and the Max Plank Institute of Biochemistry have unravelled the mysteries of how the pyrenoid is assembled. These insights can help to engineer crops that remove more carbon dioxide from the atmosphere while producing more food.

A warming planet

Im Focus: Highly precise wiring in the Cerebral Cortex

Our brains house extremely complex neuronal circuits, whose detailed structures are still largely unknown. This is especially true for the so-called cerebral cortex of mammals, where among other things vision, thoughts or spatial orientation are being computed. Here the rules by which nerve cells are connected to each other are only partly understood. A team of scientists around Moritz Helmstaedter at the Frankfiurt Max Planck Institute for Brain Research and Helene Schmidt (Humboldt University in Berlin) have now discovered a surprisingly precise nerve cell connectivity pattern in the part of the cerebral cortex that is responsible for orienting the individual animal or human in space.

The researchers report online in Nature (Schmidt et al., 2017. Axonal synapse sorting in medial entorhinal cortex, DOI: 10.1038/nature24005) that synapses in...

Im Focus: Tiny lasers from a gallery of whispers

New technique promises tunable laser devices

Whispering gallery mode (WGM) resonators are used to make tiny micro-lasers, sensors, switches, routers and other devices. These tiny structures rely on a...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

“Lasers in Composites Symposium” in Aachen – from Science to Application

19.09.2017 | Event News

I-ESA 2018 – Call for Papers

12.09.2017 | Event News

EMBO at Basel Life, a new conference on current and emerging life science research

06.09.2017 | Event News

 
Latest News

Goodbye, login. Hello, heart scan

26.09.2017 | Information Technology

The material that obscures supermassive black holes

26.09.2017 | Physics and Astronomy

Ageless ears? Elderly barn owls do not become hard of hearing

26.09.2017 | Life Sciences

VideoLinks
B2B-VideoLinks
More VideoLinks >>>