Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Green-glowing fish provides new insights into health impacts of pollution

18.04.2012
Understanding the damage that pollution causes to both wildlife and human health is set to become much easier thanks to a new green-glowing zebrafish.

Created by a team from the University of Exeter, the fish makes it easier than ever before to see where in the body environmental chemicals act and how they affect health.


Understanding the damage that pollution causes to both wildlife and human health is set to become much easier thanks to a new green-glowing zebrafish. Created by a team from the University of Exeter, the fish makes it easier than ever before to see where in the body environmental chemicals act and how they affect health. Credit: University of Exeter

The fluorescent fish has shown that oestrogenic chemicals, which are already linked to reproductive problems, impact on more parts of the body than previously thought.

The research by the University of Exeter and UCL (University College London) is published today (18 April 2012) in the journal Environmental Health Perspectives.

Numerous studies have linked 'endocrine-disrupting' chemicals, used in a wide range of industrial products and contraceptive pharmaceuticals, to reproductive problems in wildlife and humans. Previous University of Exeter research identified the potential for a major group of 'these chemicals to cause male fish to change gender. Human exposure to these chemicals, which can alter hormone signalling in the body, has been associated with decreases in sperm count and other health problems, including breast and testicular cancer.

Scientists worldwide are now working to find better ways of screening and testing for these chemicals in the body, to target the health risks to humans and wildlife. This new development, led by Dr Tetsuhiro Kudoh and Professor Charles Tyler at the University of Exeter, gives the first comprehensive insight into the effects of these chemicals on the whole body. It shows that more organs and parts of the body react to environmental estrogens than previously thought.

The team created a new transgenic zebrafish, which when exposed to environmental oestrogens shows where these chemicals work in the body through the production of green fluorescent signals. The research team tested the fish's sensitivity to different chemicals known to affect oestrogen hormone signalling, including ethinyloestradiol, used in the contraceptive pill and hormone replacement therapy treatments, nonylphenol, used in paints and industrial detergents, and Bisphenol A, which is found in many plastics.

Eventually, they produced a fish that was sufficiently sensitive to the chemicals to give fluorescent green signals to show which parts of its body were responding. This was done by placing a genetic system into the fish that amplifies the response to oestrogens producing the fluorescent green signal.

In the laboratory, PhD student Okhyun Lee exposed the fish to chemicals at levels found in wastewaters that are discharged into our rivers. She was then able to observe the effects of the exposure on the fish, in real time, watching specific organs or areas of tissue glow green, in response to the chemicals.

The team identified responses in parts of the body already associated with these chemicals: for example, the liver and, in the case of Bisphenol A, the heart. They also witnessed responses in tissues that were not previously known to be targeted by these chemicals, including the skeletal muscle and eyes.

Corresponding author Professor Charles Tyler of the University of Exeter said: "This is a very exciting development in the international effort to understand the impact of oestrogenic chemicals on the environment and human health. This zebrafish gives us a more comprehensive view than ever before of the potential effects of these hormone-disrupting chemicals on the body.

"By being able to localise precisely where different environmental oestrogens act in the body, we will be able to more effectively target health effects analyses for these chemicals of concern. While it is still early days, we are confident that our zebrafish model can help us better understand the way the human body responds to these pollutants."

Sarah Hoyle | EurekAlert!
Further information:
http://www.exeter.ac.uk

More articles from Life Sciences:

nachricht Copper hydroxide nanoparticles provide protection against toxic oxygen radicals in cigarette smoke
29.05.2017 | Johannes Gutenberg-Universität Mainz

nachricht Water forms 'spine of hydration' around DNA, group finds
26.05.2017 | Cornell University

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Strathclyde-led research develops world's highest gain high-power laser amplifier

The world's highest gain high power laser amplifier - by many orders of magnitude - has been developed in research led at the University of Strathclyde.

The researchers demonstrated the feasibility of using plasma to amplify short laser pulses of picojoule-level energy up to 100 millijoules, which is a 'gain'...

Im Focus: Can the immune system be boosted against Staphylococcus aureus by delivery of messenger RNA?

Staphylococcus aureus is a feared pathogen (MRSA, multi-resistant S. aureus) due to frequent resistances against many antibiotics, especially in hospital infections. Researchers at the Paul-Ehrlich-Institut have identified immunological processes that prevent a successful immune response directed against the pathogenic agent. The delivery of bacterial proteins with RNA adjuvant or messenger RNA (mRNA) into immune cells allows the re-direction of the immune response towards an active defense against S. aureus. This could be of significant importance for the development of an effective vaccine. PLOS Pathogens has published these research results online on 25 May 2017.

Staphylococcus aureus (S. aureus) is a bacterium that colonizes by far more than half of the skin and the mucosa of adults, usually without causing infections....

Im Focus: A quantum walk of photons

Physicists from the University of Würzburg are capable of generating identical looking single light particles at the push of a button. Two new studies now demonstrate the potential this method holds.

The quantum computer has fuelled the imagination of scientists for decades: It is based on fundamentally different phenomena than a conventional computer....

Im Focus: Turmoil in sluggish electrons’ existence

An international team of physicists has monitored the scattering behaviour of electrons in a non-conducting material in real-time. Their insights could be beneficial for radiotherapy.

We can refer to electrons in non-conducting materials as ‘sluggish’. Typically, they remain fixed in a location, deep inside an atomic composite. It is hence...

Im Focus: Wafer-thin Magnetic Materials Developed for Future Quantum Technologies

Two-dimensional magnetic structures are regarded as a promising material for new types of data storage, since the magnetic properties of individual molecular building blocks can be investigated and modified. For the first time, researchers have now produced a wafer-thin ferrimagnet, in which molecules with different magnetic centers arrange themselves on a gold surface to form a checkerboard pattern. Scientists at the Swiss Nanoscience Institute at the University of Basel and the Paul Scherrer Institute published their findings in the journal Nature Communications.

Ferrimagnets are composed of two centers which are magnetized at different strengths and point in opposing directions. Two-dimensional, quasi-flat ferrimagnets...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

Marine Conservation: IASS Contributes to UN Ocean Conference in New York on 5-9 June

24.05.2017 | Event News

AWK Aachen Machine Tool Colloquium 2017: Internet of Production for Agile Enterprises

23.05.2017 | Event News

Dortmund MST Conference presents Individualized Healthcare Solutions with micro and nanotechnology

22.05.2017 | Event News

 
Latest News

Camera on NASA's Lunar Orbiter survived 2014 meteoroid hit

29.05.2017 | Physics and Astronomy

Strathclyde-led research develops world's highest gain high-power laser amplifier

29.05.2017 | Physics and Astronomy

A 3-D look at the 2015 El Niño

29.05.2017 | Earth Sciences

VideoLinks
B2B-VideoLinks
More VideoLinks >>>