Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:


Glass Sponges Inspire

Hybrid material made of collagen fibers and silica as a possible substrate for bone tissue culture

As well as organic structures, mineral structures also play an important role in living organisms. You don’t even have to go as far as seashells or the artful silica scaffolds of diatoms; a glimpse into your own body will do. Our bones and teeth are made of the mineral hydroxyapatite.

Scientists try to imitate the processes of biomineralization in order to better repair such things as bones and teeth. A team led by Franklin R. Tay at the Georgia Health Sciences University (USA) and Ji-hua Chen at the Fourth Military Medical University (China) has now introduced a new approach in the journal Angewandte Chemie: the biomineralization of a collagen/silica hybrid material.

Biomineralization is a very complicated process that is not so easy to mimic.

The silicate precursors required for the synthesis of the cell walls of diatoms are in a stabilized form, which prevents their uncontrolled polymerization. Special proteins then control the polymerization to make the highly complex structures of the resulting scaffold. Researchers would also like to control biomineralization processes to repair damaged teeth or to make synthetic cartilage and bone tissue. In order to culture bones, scientists would like to seed osteoblasts (bone building cells) from the patient’s own body onto a substrate, where they would attach and multiply. This scaffolding would be implanted to help damaged bone, in cases of osteoporosis-induced or highly complicated fractures for example, to regenerate. Osteoblasts release collagen, calcium phosphate, and calcium carbonate as the basis for new bone material.

Collagen fibers would be an ideal substrate, but they are not solid enough for bone repair. The researchers once again turned to nature for inspiration: in glass sponges, a collagen matrix is one component of the silica scaffolding. Would it thus be possible to strengthen a collagen structure with silica (silicon dioxide)? Although many teams have previously failed in their attempts, the team led by Tay and Chen has now been successful.

They used collagen fibers as both a “mold” and a catalyst for the polymerization of the liquid phase of a silica precursor compound to make solid silica. The silica precursor is stabilized with choline to prevent an uncontrolled polymerization. This leaves enough time for the liquid precursor to fully infiltrate the space between the microfibrils of the collagen fibers before it polymerizes to form silica—one secret to the success of this new approach. After the polymerization the solid silica reflects the architecture determined by the collagen fibers. After drying, the original sponge-like, porous structure of the collagen fibers is maintained. In contrast to pure collagen, the scaffold of the hybrid compound is stable and could, the researchers hope, be used to repair bones.

Author: Franklin R. Tay, Georgia Health Sciences University, Augusta (USA),
Title: Infiltration of Silica Inside Fibrillar Collagen
Angewandte Chemie International Edition, Permalink to the article:

Franklin R. Tay | Angewandte Chemie
Further information:

More articles from Life Sciences:

nachricht Don't Give the Slightest Chance to Toxic Elements in Medicinal Products
23.03.2018 | Physikalisch-Technische Bundesanstalt (PTB)

nachricht North and South Cooperation to Combat Tuberculosis
22.03.2018 | Universität Zürich

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Space observation with radar to secure Germany's space infrastructure

Satellites in near-Earth orbit are at risk due to the steady increase in space debris. But their mission in the areas of telecommunications, navigation or weather forecasts is essential for society. Fraunhofer FHR therefore develops radar-based systems which allow the detection, tracking and cataloging of even the smallest particles of debris. Satellite operators who have access to our data are in a better position to plan evasive maneuvers and prevent destructive collisions. From April, 25-29 2018, Fraunhofer FHR and its partners will exhibit the complementary radar systems TIRA and GESTRA as well as the latest radar techniques for space observation across three stands at the ILA Berlin.

The "traffic situation" in space is very tense: the Earth is currently being orbited not only by countless satellites but also by a large volume of space...

Im Focus: Researchers Discover New Anti-Cancer Protein

An international team of researchers has discovered a new anti-cancer protein. The protein, called LHPP, prevents the uncontrolled proliferation of cancer cells in the liver. The researchers led by Prof. Michael N. Hall from the Biozentrum, University of Basel, report in “Nature” that LHPP can also serve as a biomarker for the diagnosis and prognosis of liver cancer.

The incidence of liver cancer, also known as hepatocellular carcinoma, is steadily increasing. In the last twenty years, the number of cases has almost doubled...

Im Focus: Researchers at Fraunhofer monitor re-entry of Chinese space station Tiangong-1

In just a few weeks from now, the Chinese space station Tiangong-1 will re-enter the Earth's atmosphere where it will to a large extent burn up. It is possible that some debris will reach the Earth's surface. Tiangong-1 is orbiting the Earth uncontrolled at a speed of approx. 29,000 km/h.Currently the prognosis relating to the time of impact currently lies within a window of several days. The scientists at Fraunhofer FHR have already been monitoring Tiangong-1 for a number of weeks with their TIRA system, one of the most powerful space observation radars in the world, with a view to supporting the German Space Situational Awareness Center and the ESA with their re-entry forecasts.

Following the loss of radio contact with Tiangong-1 in 2016 and due to the low orbital height, it is now inevitable that the Chinese space station will...

Im Focus: Alliance „OLED Licht Forum“ – Key partner for OLED lighting solutions

Fraunhofer Institute for Organic Electronics, Electron Beam and Plasma Technology FEP, provider of research and development services for OLED lighting solutions, announces the founding of the “OLED Licht Forum” and presents latest OLED design and lighting solutions during light+building, from March 18th – 23rd, 2018 in Frankfurt a.M./Germany, at booth no. F91 in Hall 4.0.

They are united in their passion for OLED (organic light emitting diodes) lighting with all of its unique facets and application possibilities. Thus experts in...

Im Focus: Mars' oceans formed early, possibly aided by massive volcanic eruptions

Oceans formed before Tharsis and evolved together, shaping climate history of Mars

A new scenario seeking to explain how Mars' putative oceans came and went over the last 4 billion years implies that the oceans formed several hundred million...

All Focus news of the innovation-report >>>



Industry & Economy
Event News

New solar solutions for sustainable buildings and cities

23.03.2018 | Event News

Virtual reality conference comes to Reutlingen

19.03.2018 | Event News

Ultrafast Wireless and Chip Design at the DATE Conference in Dresden

16.03.2018 | Event News

Latest News

For graphite pellets, just add elbow grease

23.03.2018 | Materials Sciences

Unique communication strategy discovered in stem cell pathway controlling plant growth

23.03.2018 | Agricultural and Forestry Science

Sharpening the X-ray view of the nanocosm

23.03.2018 | Physics and Astronomy

Science & Research
Overview of more VideoLinks >>>