Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

German Research Foundation approves new priority program in the life sciences

15.04.2014

Funding to be provided for national program on "Chemical Biology of Native Nucleic Acid Modifications" coordinated by Mainz University

In recent years, it has become clear that the genetic code is far more complex than previously assumed. In addition to the well-known building blocks adenine, cytosine, guanine, and thymine, numerous chemical variations play an important role.

Scientists now assume that the newly discovered nucleic acid modifications may form a second layer of information that extends and complements the genetic code. "The new discoveries are rather like umlauts that extend the standard alphabet," explained Professor Mark Helm of the Institute of Pharmaceutical Sciences and Biochemistry - Therapeutic Life Sciences at Johannes Gutenberg University Mainz (JGU). Helm is the coordinator of the priority program "Chemical Biology of Native Nucleic Acid Modifications", which the German Research Foundation (DFG) has now agreed to fund.

This nationwide priority program will start in 2015 and, according to plans, will continue to receive DFG support for six years. "We are lucky enough in Germany to have some of the leading international researchers in all the core areas in this field and we thus intend to explore this subject with the help of a country-wide network," said Helm. Decoding the information in the modified DNA and RNA bases and nucleosides is a hot topic in chemical biology right now.

Before 2009, scientists were convinced that only the four Watson-Crick bases plus a fifth base called 5-methylcytosine code for the genetic information that is key to life. Then three additional DNA modifications were uncovered in quick succession, which are postulated to act as switches that regulate gene functions. The switch can be used to activate or deactivate a gene.

"We are looking at a completely new coding mechanism that had previously escaped our attention," Helm pointed out. On the other hand, scientists have long known that RNA, which is responsible for translating the genetic code into proteins, contains more than 150 different modified nucleosides. The purpose of these, however, is still largely unknown.

The new research network will closely examine the molecular details of the modifications in naturally occurring nucleic acids. This will involve, among other things, detecting and identifying modifications, localizing and quantifying them, and uncovering both their structure and function. In an initial period, an emphasis will be on methods from chemistry and structural biology, allowing to connect to scientists from the life sciences in joint projects. The German Research Foundation will issue a call for proposals in this innovative and interdisciplinary research program.

Further information:
Professor Dr. Mark Helm
Medical / Pharmaceutical Chemistry
Institute of Pharmaceutical Sciences and Biochemistry – Therapeutic Life Sciences
Johannes Gutenberg University Mainz
D 55099 Mainz, GERMANY
phone +49 6131 39-25731
fax +49 6131 39-20373
e-mail: mhelm@uni-mainz.de
http://www.pharmazie.uni-mainz.de/AK-Helm/index_ENG.php

Related links:
http://www.dfg.de/en/service/press/press_releases/2014/press_release_no_10/index... - DFG press release “16 New Priority Programmes”

Weitere Informationen:

http://www.uni-mainz.de/presse/17224_ENG_HTML.php - press release

Petra Giegerich | idw - Informationsdienst Wissenschaft

Further reports about: Biochemistry DFG DNA Foundation Pharmaceutical RNA acids modifications thymine

More articles from Life Sciences:

nachricht How brains surrender to sleep
23.06.2017 | IMP - Forschungsinstitut für Molekulare Pathologie GmbH

nachricht A new technique isolates neuronal activity during memory consolidation
22.06.2017 | Spanish National Research Council (CSIC)

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Can we see monkeys from space? Emerging technologies to map biodiversity

An international team of scientists has proposed a new multi-disciplinary approach in which an array of new technologies will allow us to map biodiversity and the risks that wildlife is facing at the scale of whole landscapes. The findings are published in Nature Ecology and Evolution. This international research is led by the Kunming Institute of Zoology from China, University of East Anglia, University of Leicester and the Leibniz Institute for Zoo and Wildlife Research.

Using a combination of satellite and ground data, the team proposes that it is now possible to map biodiversity with an accuracy that has not been previously...

Im Focus: Climate satellite: Tracking methane with robust laser technology

Heatwaves in the Arctic, longer periods of vegetation in Europe, severe floods in West Africa – starting in 2021, scientists want to explore the emissions of the greenhouse gas methane with the German-French satellite MERLIN. This is made possible by a new robust laser system of the Fraunhofer Institute for Laser Technology ILT in Aachen, which achieves unprecedented measurement accuracy.

Methane is primarily the result of the decomposition of organic matter. The gas has a 25 times greater warming potential than carbon dioxide, but is not as...

Im Focus: How protons move through a fuel cell

Hydrogen is regarded as the energy source of the future: It is produced with solar power and can be used to generate heat and electricity in fuel cells. Empa researchers have now succeeded in decoding the movement of hydrogen ions in crystals – a key step towards more efficient energy conversion in the hydrogen industry of tomorrow.

As charge carriers, electrons and ions play the leading role in electrochemical energy storage devices and converters such as batteries and fuel cells. Proton...

Im Focus: A unique data centre for cosmological simulations

Scientists from the Excellence Cluster Universe at the Ludwig-Maximilians-Universität Munich have establised "Cosmowebportal", a unique data centre for cosmological simulations located at the Leibniz Supercomputing Centre (LRZ) of the Bavarian Academy of Sciences. The complete results of a series of large hydrodynamical cosmological simulations are available, with data volumes typically exceeding several hundred terabytes. Scientists worldwide can interactively explore these complex simulations via a web interface and directly access the results.

With current telescopes, scientists can observe our Universe’s galaxies and galaxy clusters and their distribution along an invisible cosmic web. From the...

Im Focus: Scientists develop molecular thermometer for contactless measurement using infrared light

Temperature measurements possible even on the smallest scale / Molecular ruby for use in material sciences, biology, and medicine

Chemists at Johannes Gutenberg University Mainz (JGU) in cooperation with researchers of the German Federal Institute for Materials Research and Testing (BAM)...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

Plants are networkers

19.06.2017 | Event News

Digital Survival Training for Executives

13.06.2017 | Event News

Global Learning Council Summit 2017

13.06.2017 | Event News

 
Latest News

Quantum thermometer or optical refrigerator?

23.06.2017 | Physics and Astronomy

A 100-year-old physics problem has been solved at EPFL

23.06.2017 | Physics and Astronomy

Equipping form with function

23.06.2017 | Information Technology

VideoLinks
B2B-VideoLinks
More VideoLinks >>>