Funding to be provided for national program on "Chemical Biology of Native Nucleic Acid Modifications" coordinated by Mainz University
In recent years, it has become clear that the genetic code is far more complex than previously assumed. In addition to the well-known building blocks adenine, cytosine, guanine, and thymine, numerous chemical variations play an important role.
Scientists now assume that the newly discovered nucleic acid modifications may form a second layer of information that extends and complements the genetic code. "The new discoveries are rather like umlauts that extend the standard alphabet," explained Professor Mark Helm of the Institute of Pharmaceutical Sciences and Biochemistry - Therapeutic Life Sciences at Johannes Gutenberg University Mainz (JGU). Helm is the coordinator of the priority program "Chemical Biology of Native Nucleic Acid Modifications", which the German Research Foundation (DFG) has now agreed to fund.
This nationwide priority program will start in 2015 and, according to plans, will continue to receive DFG support for six years. "We are lucky enough in Germany to have some of the leading international researchers in all the core areas in this field and we thus intend to explore this subject with the help of a country-wide network," said Helm. Decoding the information in the modified DNA and RNA bases and nucleosides is a hot topic in chemical biology right now.
Before 2009, scientists were convinced that only the four Watson-Crick bases plus a fifth base called 5-methylcytosine code for the genetic information that is key to life. Then three additional DNA modifications were uncovered in quick succession, which are postulated to act as switches that regulate gene functions. The switch can be used to activate or deactivate a gene.
"We are looking at a completely new coding mechanism that had previously escaped our attention," Helm pointed out. On the other hand, scientists have long known that RNA, which is responsible for translating the genetic code into proteins, contains more than 150 different modified nucleosides. The purpose of these, however, is still largely unknown.
The new research network will closely examine the molecular details of the modifications in naturally occurring nucleic acids. This will involve, among other things, detecting and identifying modifications, localizing and quantifying them, and uncovering both their structure and function. In an initial period, an emphasis will be on methods from chemistry and structural biology, allowing to connect to scientists from the life sciences in joint projects. The German Research Foundation will issue a call for proposals in this innovative and interdisciplinary research program.
Professor Dr. Mark Helm
Medical / Pharmaceutical Chemistry
Institute of Pharmaceutical Sciences and Biochemistry – Therapeutic Life Sciences
Johannes Gutenberg University Mainz
D 55099 Mainz, GERMANY
phone +49 6131 39-25731
fax +49 6131 39-20373
http://www.dfg.de/en/service/press/press_releases/2014/press_release_no_10/index... - DFG press release “16 New Priority Programmes”
http://www.uni-mainz.de/presse/17224_ENG_HTML.php - press release
Petra Giegerich | idw - Informationsdienst Wissenschaft
Chains of nanogold – forged with atomic precision
23.09.2016 | Suomen Akatemia (Academy of Finland)
Self-assembled nanostructures hit their target
23.09.2016 | King Abdullah University of Science and Technology
The Fraunhofer Institute for Organic Electronics, Electron Beam and Plasma Technology FEP has been developing various applications for OLED microdisplays based on organic semiconductors. By integrating the capabilities of an image sensor directly into the microdisplay, eye movements can be recorded by the smart glasses and utilized for guidance and control functions, as one example. The new design will be debuted at Augmented World Expo Europe (AWE) in Berlin at Booth B25, October 18th – 19th.
“Augmented-reality” and “wearables” have become terms we encounter almost daily. Both can make daily life a little simpler and provide valuable assistance for...
With the help of artificial intelligence, chemists from the University of Basel in Switzerland have computed the characteristics of about two million crystals made up of four chemical elements. The researchers were able to identify 90 previously unknown thermodynamically stable crystals that can be regarded as new materials. They report on their findings in the scientific journal Physical Review Letters.
Elpasolite is a glassy, transparent, shiny and soft mineral with a cubic crystal structure. First discovered in El Paso County (Colorado, USA), it can also be...
For the first time, Fraunhofer IKTS shows additively manufactured hardmetal tools at WorldPM 2016 in Hamburg. Mechanical, chemical as well as a high heat resistance and extreme hardness are required from tools that are used in mechanical and automotive engineering or in plastics and building materials industry. Researchers at the Fraunhofer Institute for Ceramic Technologies and Systems IKTS in Dresden managed the production of complex hardmetal tools via 3D printing in a quality that are in no way inferior to conventionally produced high-performance tools.
Fraunhofer IKTS counts decades of proven expertise in the development of hardmetals. To date, reliable cutting, drilling, pressing and stamping tools made of...
At AKL’16, the International Laser Technology Congress held in May this year, interest in the topic of process control was greater than expected. Appropriately, the event was also used to launch the Industry Working Group for Process Control in Laser Material Processing. The group provides a forum for representatives from industry and research to initiate pre-competitive projects and discuss issues such as standards, potential cost savings and feasibility.
In the age of industry 4.0, laser technology is firmly established within manufacturing. A wide variety of laser techniques – from USP ablation and additive...
Every three years, the plastics industry gathers at K, the international trade fair for plastics and rubber in Düsseldorf. The Fraunhofer Institute for Laser Technology ILT will also be attending again and presenting many innovative technologies, such as for joining plastics and metals using ultrashort pulse lasers. From October 19 to 26, you can find the Fraunhofer ILT at the joint Fraunhofer booth SC01 in Hall 7.
K is the world’s largest trade fair for the plastics and rubber industry. As in previous years, the organizers are expecting 3,000 exhibitors and more than...
23.09.2016 | Event News
20.09.2016 | Event News
16.09.2016 | Event News
23.09.2016 | Life Sciences
23.09.2016 | Health and Medicine
23.09.2016 | Life Sciences