Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Genetically engineered bacteria are sweet success against IBD

24.08.2009
For the first time, scientists have used a genetically engineered "friendly" bacterium to deliver a therapy.

The treatment is for bowel disorders such as inflammatory bowel disease, which affects one in 400 people in the UK and for which there is no cure. The bacterium Bacteroides ovatus activates a protein when exposed to a specific type of sugar, xylan. In research to be published in Gut, the therapy has been proven to work in animals with colitis, one of the major forms of inflammatory bowel disease.

The bacterium is able to deliver the protein, a human growth factor called KGF-2, directly to the damaged cells that line the gut, unlike other treatments which can cause unwanted side effects. Also unlike other treatments, it is envisaged that patients will be able to control the medication themselves by ingesting xylan, perhaps in the form of a drink.

"This is the first time that anyone has been able to control a therapeutic protein in a living system using something that can be eaten," said Professor Simon Carding of the Institute of Food Research and the University of East Anglia Medical School, lead author on the research. "The beneficial bugs could be activated when they are needed."

The treatment had a significant therapeutic effect. For example, it reduced rectal bleeding, accelerated the healing of the gut lining, and reduced inflammation. It was also able to prevent the onset of disease.

"The bacterium is being used to produce other protein molecules to treat various bowel disorders and we are now applying for funding to try out the bug in humans," said Dr. Zaed Hamady, an MRC Research Fellow at Leeds University.

Since genetic engineering techniques were developed in the 1970s, scientists have found ways to apply them to medicine. Insulin was the first medicine to be genetically engineered and the first genetically engineered vaccine was for hepatitis B. The technology is now opening up ways to deliver drugs to specific targets, as with this treatment to deliver a protein directly to injured areas of the gut.

"Initially I envisage this being an adjunct therapy to patients' existing medicine, but eventually it could be the sole therapy," said Professor Carding. "Once our bugs are in the colon they could be activated when needed so we aim to use our bugs to prevent disease or relapse in IBD."

The work was funded by a grant from the Medical Research Council and the Royal College of Surgeons, and by Techtran. The Institute of Food Research is an institute of Biotechnology and Biological Sciences Research Council.

Zoe Dunford | EurekAlert!
Further information:
http://www.bbsrc.ac.uk

More articles from Life Sciences:

nachricht The birth of a new protein
20.10.2017 | University of Arizona

nachricht Building New Moss Factories
20.10.2017 | Albert-Ludwigs-Universität Freiburg im Breisgau

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Neutron star merger directly observed for the first time

University of Maryland researchers contribute to historic detection of gravitational waves and light created by event

On August 17, 2017, at 12:41:04 UTC, scientists made the first direct observation of a merger between two neutron stars--the dense, collapsed cores that remain...

Im Focus: Breaking: the first light from two neutron stars merging

Seven new papers describe the first-ever detection of light from a gravitational wave source. The event, caused by two neutron stars colliding and merging together, was dubbed GW170817 because it sent ripples through space-time that reached Earth on 2017 August 17. Around the world, hundreds of excited astronomers mobilized quickly and were able to observe the event using numerous telescopes, providing a wealth of new data.

Previous detections of gravitational waves have all involved the merger of two black holes, a feat that won the 2017 Nobel Prize in Physics earlier this month....

Im Focus: Smart sensors for efficient processes

Material defects in end products can quickly result in failures in many areas of industry, and have a massive impact on the safe use of their products. This is why, in the field of quality assurance, intelligent, nondestructive sensor systems play a key role. They allow testing components and parts in a rapid and cost-efficient manner without destroying the actual product or changing its surface. Experts from the Fraunhofer IZFP in Saarbrücken will be presenting two exhibits at the Blechexpo in Stuttgart from 7–10 November 2017 that allow fast, reliable, and automated characterization of materials and detection of defects (Hall 5, Booth 5306).

When quality testing uses time-consuming destructive test methods, it can result in enormous costs due to damaging or destroying the products. And given that...

Im Focus: Cold molecules on collision course

Using a new cooling technique MPQ scientists succeed at observing collisions in a dense beam of cold and slow dipolar molecules.

How do chemical reactions proceed at extremely low temperatures? The answer requires the investigation of molecular samples that are cold, dense, and slow at...

Im Focus: Shrinking the proton again!

Scientists from the Max Planck Institute of Quantum Optics, using high precision laser spectroscopy of atomic hydrogen, confirm the surprisingly small value of the proton radius determined from muonic hydrogen.

It was one of the breakthroughs of the year 2010: Laser spectroscopy of muonic hydrogen resulted in a value for the proton charge radius that was significantly...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

ASEAN Member States discuss the future role of renewable energy

17.10.2017 | Event News

World Health Summit 2017: International experts set the course for the future of Global Health

10.10.2017 | Event News

Climate Engineering Conference 2017 Opens in Berlin

10.10.2017 | Event News

 
Latest News

Terahertz spectroscopy goes nano

20.10.2017 | Information Technology

Strange but true: Turning a material upside down can sometimes make it softer

20.10.2017 | Materials Sciences

NRL clarifies valley polarization for electronic and optoelectronic technologies

20.10.2017 | Interdisciplinary Research

VideoLinks
B2B-VideoLinks
More VideoLinks >>>