Ghrelin is a neuropeptide that both activates the brain’s reward system and increases appetite. This means that when we are hungry, levels of ghrelin increase, activating the brain’s reward system, and this, in turn, increases our motivation to look for food. Previous research from the Sahlgrenska Academy has linked ghrelin to the development of various dependencies, such as drug addiction and alcoholism.
In a new study published in the online version of the journal PlosOne, researchers examined the genes of 579 individuals chosen from the general public. It emerged that people with certain changes in the ghrelin gene consume more sugar than their peers who do not have these changes. This link was also seen in people who consumed large amounts of both sugar and alcohol.
Trials have also been carried out using rats, where the researchers found that when ghrelin was blocked the rats reduced their consumption of sugar and were less motivated to hunt for sugar.
“This shows that ghrelin is a strong driver when it comes to tracking down rewarding substances such as sugar or alcohol,” says researcher Elisabet Jerlhag from the Sahlgrenska Academy’s Department of Pharmacology.
These results go hand in hand with the researchers’ previous findings which showed that substances that block the ghrelin system reduce the positive effects of addictive drugs and that changes in the ghrelin gene are associated with high alcohol consumption, weight gain in alcoholics and smoking.
The researchers are now a step closer to understanding what happens in the brain and the body in different types of addictive behavior. Understanding these mechanisms means that new drugs can be developed to block the ghrelin system and used to treat patients who are addicted to alcohol or who suffer from binge-eating disorders.
“This knowledge could also make it easier for society to view dependency as an illness and could mean that these people can get the treatment they need more readily,” says Jerlhag.For more information, please contact:
tel: +46 (0)31 786 3418, mobile: +46 (0)736 483 336, e-mail: firstname.lastname@example.orgJournal: PlosOne
Authors: Sara Landgren, Jeffrey A Simms, Dag S Thelle, Elisabeth Strandhagen, Lauren Lissner, Selena E Bartlett, Jörgen A Engel, Elisabet JerlhagWeitere Informationen:
Helena Aaberg | idw
Water forms 'spine of hydration' around DNA, group finds
26.05.2017 | Cornell University
How herpesviruses win the footrace against the immune system
26.05.2017 | Helmholtz-Zentrum für Infektionsforschung
Staphylococcus aureus is a feared pathogen (MRSA, multi-resistant S. aureus) due to frequent resistances against many antibiotics, especially in hospital infections. Researchers at the Paul-Ehrlich-Institut have identified immunological processes that prevent a successful immune response directed against the pathogenic agent. The delivery of bacterial proteins with RNA adjuvant or messenger RNA (mRNA) into immune cells allows the re-direction of the immune response towards an active defense against S. aureus. This could be of significant importance for the development of an effective vaccine. PLOS Pathogens has published these research results online on 25 May 2017.
Staphylococcus aureus (S. aureus) is a bacterium that colonizes by far more than half of the skin and the mucosa of adults, usually without causing infections....
Physicists from the University of Würzburg are capable of generating identical looking single light particles at the push of a button. Two new studies now demonstrate the potential this method holds.
The quantum computer has fuelled the imagination of scientists for decades: It is based on fundamentally different phenomena than a conventional computer....
An international team of physicists has monitored the scattering behaviour of electrons in a non-conducting material in real-time. Their insights could be beneficial for radiotherapy.
We can refer to electrons in non-conducting materials as ‘sluggish’. Typically, they remain fixed in a location, deep inside an atomic composite. It is hence...
Two-dimensional magnetic structures are regarded as a promising material for new types of data storage, since the magnetic properties of individual molecular building blocks can be investigated and modified. For the first time, researchers have now produced a wafer-thin ferrimagnet, in which molecules with different magnetic centers arrange themselves on a gold surface to form a checkerboard pattern. Scientists at the Swiss Nanoscience Institute at the University of Basel and the Paul Scherrer Institute published their findings in the journal Nature Communications.
Ferrimagnets are composed of two centers which are magnetized at different strengths and point in opposing directions. Two-dimensional, quasi-flat ferrimagnets...
An Australian-Chinese research team has created the world's thinnest hologram, paving the way towards the integration of 3D holography into everyday...
24.05.2017 | Event News
23.05.2017 | Event News
22.05.2017 | Event News
26.05.2017 | Life Sciences
26.05.2017 | Life Sciences
26.05.2017 | Physics and Astronomy