Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Genetic predictors of esophageal cancer identified

07.11.2008
Researchers have identified 11 genotypes that may increase esophageal cancer risk, according to research published in the November issue of Cancer Prevention Research, a journal of the American Association for Cancer Research.

"We observed a significantly increased risk of esophageal cancer with increasing numbers of risk genotypes," said Yuanqing Ye, Ph.D., an instructor in the Department of Epidemiology at the University of Texas M. D. Anderson Cancer Center.

Major risk factors for esophageal cancer include obesity, smoking and gastroesophageal reflux disease. Compared to the high prevalence of these risk factors in the general population, the incidence rate of esophageal cancer is low, indicating that a small percentage of people are genetically predisposed to develop esophageal cancer.

Researchers at the University of Texas M. D. Anderson Cancer Center identified 11 single-nucleotide polymorphisms (SNPs) in microRNA-related genes that showed at least a borderline significant association with esophageal cancer. A person can have one or more of these SNPs in their genetic makeup, putting him or her into low-risk, medium-risk and high-risk groups. The study showed that each unfavorable genotype was associated with an increased cancer risk. Individuals with more than four unfavorable genotypes were more than three times as likely to develop esophageal cancer.

"Our ultimate goal is to construct a quantitative cancer risk prediction model based on an individual's epidemiological profile, environment exposure and genetic makeup," said Xifeng Wu, M.D., Ph.D., a professor in the Department of Epidemiology at the University of Texas M. D. Anderson Cancer Center and lead author of the study. "This risk prediction model can evaluate each person's relative risk and absolute risk of developing esophageal cancer within a certain time period."

Esophageal cancer is the fastest growing cancer in the United States with significantly increasing rates of occurrence. The majority of esophageal cancer patients are diagnosed at an advanced stage with poor prognosis. Understanding what places a person at high risk for esophageal cancer may have clinical applications to guide cancer screening, intensive monitoring, and cancer prevention.

"Considering the dramatic increase in incidence, difficulty of early diagnosis, the poor survival rate for esophageal cancer, and the limited knowledge of the natural history of this tumor, we need a greater understanding of the etiology of esophageal cancer for improvement of diagnosis and hopefully a better prognosis," said Wu.

Jeremy Moore | EurekAlert!
Further information:
http://www.aacr.org

More articles from Life Sciences:

nachricht Scientists enlist engineered protein to battle the MERS virus
22.05.2017 | University of Toronto

nachricht Insight into enzyme's 3-D structure could cut biofuel costs
19.05.2017 | DOE/Los Alamos National Laboratory

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Wafer-thin Magnetic Materials Developed for Future Quantum Technologies

Two-dimensional magnetic structures are regarded as a promising material for new types of data storage, since the magnetic properties of individual molecular building blocks can be investigated and modified. For the first time, researchers have now produced a wafer-thin ferrimagnet, in which molecules with different magnetic centers arrange themselves on a gold surface to form a checkerboard pattern. Scientists at the Swiss Nanoscience Institute at the University of Basel and the Paul Scherrer Institute published their findings in the journal Nature Communications.

Ferrimagnets are composed of two centers which are magnetized at different strengths and point in opposing directions. Two-dimensional, quasi-flat ferrimagnets...

Im Focus: World's thinnest hologram paves path to new 3-D world

Nano-hologram paves way for integration of 3-D holography into everyday electronics

An Australian-Chinese research team has created the world's thinnest hologram, paving the way towards the integration of 3D holography into everyday...

Im Focus: Using graphene to create quantum bits

In the race to produce a quantum computer, a number of projects are seeking a way to create quantum bits -- or qubits -- that are stable, meaning they are not much affected by changes in their environment. This normally needs highly nonlinear non-dissipative elements capable of functioning at very low temperatures.

In pursuit of this goal, researchers at EPFL's Laboratory of Photonics and Quantum Measurements LPQM (STI/SB), have investigated a nonlinear graphene-based...

Im Focus: Bacteria harness the lotus effect to protect themselves

Biofilms: Researchers find the causes of water-repelling properties

Dental plaque and the viscous brown slime in drainpipes are two familiar examples of bacterial biofilms. Removing such bacterial depositions from surfaces is...

Im Focus: Hydrogen Bonds Directly Detected for the First Time

For the first time, scientists have succeeded in studying the strength of hydrogen bonds in a single molecule using an atomic force microscope. Researchers from the University of Basel’s Swiss Nanoscience Institute network have reported the results in the journal Science Advances.

Hydrogen is the most common element in the universe and is an integral part of almost all organic compounds. Molecules and sections of macromolecules are...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

Dortmund MST Conference presents Individualized Healthcare Solutions with micro and nanotechnology

22.05.2017 | Event News

Innovation 4.0: Shaping a humane fourth industrial revolution

17.05.2017 | Event News

Media accreditation opens for historic year at European Health Forum Gastein

16.05.2017 | Event News

 
Latest News

New approach to revolutionize the production of molecular hydrogen

22.05.2017 | Materials Sciences

Scientists enlist engineered protein to battle the MERS virus

22.05.2017 | Life Sciences

Experts explain origins of topographic relief on Earth, Mars and Titan

22.05.2017 | Physics and Astronomy

VideoLinks
B2B-VideoLinks
More VideoLinks >>>