Now, scientists at the Max Planck Institute of Biochemistry (MPIB) in Martinsried near Munich, Germany, succeeded in making another important step in this research area: For the first time, they were able to integrate in a single experiment three different synthetic amino acids into one protein. (Angewandte Chemie, June 24, 2010).
Proteins are the main actors in our body: They transport substances, convey messages or carry out vital processes in their role as molecular machines. The “helmsmen of the cell” are composed of amino acids, whose sequence is already defined by the heritable information in every living being. The translation of this information during the production of proteins (protein synthesis) is determined by the genetic code. 20 amino acids form the standard set of which proteins are built. In natural conditions, however, several hundred amino acids can be found and, of course, new amino acids can also be produced in the laboratory. With regard to their properties, they differ from the 20 standard amino acids, because of which, by their integration in proteins, specific structural and biological characteristics of proteins can be systematically changed. So far, only one type of synthetic amino acid could be inserted into a protein during a single experiment in a residue-specific manner; thus, only one property of a protein could be modified at once.
Nediljko Budisa, head of the research group Molecular Biotechnology at the MPIB, has now made an important methodical progress in the area of genetic code engineering. The scientists were able to substitute three different natural amino acids by synthetic ones at the same time in a single experiment. The biochemist is pleased: “The research area of genetic code engineering and code extension reaches with this a new development phase.”
Budisa’s method could be of great importance particularly for the industry and economy because the production of artificial proteins by genetic code engineering in his view demonstrates a solid basis for the development of new technologies. “During integration, synthetic amino acids confer their characteristics to proteins. Thus, the development moves over totally new classes of products, whose chemical synthesis has not been possible so far by conventional protein engineering using only the 20 standard amino acids”, explains Budisa regarding to future prospects. “Thanks to our method, in the future it will be possible to tailor industrial relevant proteins with novel properties: for example proteins containing medical components.” [UD]Original Publication:
Ion treatments for cardiac arrhythmia — Non-invasive alternative to catheter-based surgery
20.01.2017 | GSI Helmholtzzentrum für Schwerionenforschung GmbH
Seeking structure with metagenome sequences
20.01.2017 | DOE/Joint Genome Institute
An important step towards a completely new experimental access to quantum physics has been made at University of Konstanz. The team of scientists headed by...
Yersiniae cause severe intestinal infections. Studies using Yersinia pseudotuberculosis as a model organism aim to elucidate the infection mechanisms of these...
Researchers from the University of Hamburg in Germany, in collaboration with colleagues from the University of Aarhus in Denmark, have synthesized a new superconducting material by growing a few layers of an antiferromagnetic transition-metal chalcogenide on a bismuth-based topological insulator, both being non-superconducting materials.
While superconductivity and magnetism are generally believed to be mutually exclusive, surprisingly, in this new material, superconducting correlations...
Laser-driving of semimetals allows creating novel quasiparticle states within condensed matter systems and switching between different states on ultrafast time scales
Studying properties of fundamental particles in condensed matter systems is a promising approach to quantum field theory. Quasiparticles offer the opportunity...
Among the general public, solar thermal energy is currently associated with dark blue, rectangular collectors on building roofs. Technologies are needed for aesthetically high quality architecture which offer the architect more room for manoeuvre when it comes to low- and plus-energy buildings. With the “ArKol” project, researchers at Fraunhofer ISE together with partners are currently developing two façade collectors for solar thermal energy generation, which permit a high degree of design flexibility: a strip collector for opaque façade sections and a solar thermal blind for transparent sections. The current state of the two developments will be presented at the BAU 2017 trade fair.
As part of the “ArKol – development of architecturally highly integrated façade collectors with heat pipes” project, Fraunhofer ISE together with its partners...
19.01.2017 | Event News
10.01.2017 | Event News
09.01.2017 | Event News
20.01.2017 | Awards Funding
20.01.2017 | Materials Sciences
20.01.2017 | Life Sciences