Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Gene Variant May Protect Memory and Thinking Skills in Older People

20.04.2010
New research shows a gene variant may help protect the memory and thinking skills of older people. The research will be published in the April 20, 2010, issue of Neurology®, the medical journal of the American Academy of Neurology.

“This is the first study to identify a protective relationship between this gene variant and cognitive function,” said study author Alexandra Fiocco, PhD, with the University of California, San Francisco.

For the study, researchers followed 2,858 African-American and Caucasian people between the ages of 70 and 79 for eight years. Participants’ DNA was analyzed for the catechol-O-methyltransferase (COMT) gene, a gene shown in studies to affect thinking skills. The allelic variants associated with this gene are the Val and Met variants.

The group was also given two types of thinking tests. One test measured skills such as language, concentration and memory. The other test measured response time, attention and judging sights and objects.

The study found that the Met variant of the COMT gene was linked to a greater decline in thinking skills over the years, while the Val variant had a protective effect on thinking skills, with lower declines over the years. In Caucasians, those with the Val variant scored 33 percent better over time than those without the variant. Among African-Americans, people with the Val allele gene variant scored 45 percent better over time than those who did not have the variant.

“This finding is interesting because in younger people, the Val genotype has been shown to have a detrimental effect,” Fiocco said. “But in our study of older people, the reverse was true. Finding connections between this gene, its variants and cognitive function may help scientists find new treatments for the prevention of cognitive decline.” Fiocco added, however, that the results need to be replicated by others before the field can be confident that the Met variant of the COMT gene plays a role in late life cognitive decline.

The study was supported by the National Institutes of Health and the National Institute on Aging.

The American Academy of Neurology, an association of more than 22,000 neurologists and neuroscience professionals, is dedicated to promoting the highest quality patient-centered neurologic care. A neurologist is a doctor with specialized training in diagnosing, treating and managing disorders of the brain and nervous system such as Parkinson’s disease, ALS (Lou Gehrig’s disease), dementia, West Nile virus and ataxia. For more information about the American Academy of Neurology, visit http://www.aan.com.

Rachel L. Seroka | American Academy of Neurology
Further information:
http://www.aan.com

More articles from Life Sciences:

nachricht CRISPR meets single-cell sequencing in new screening method
19.01.2017 | CeMM Forschungszentrum für Molekulare Medizin der Österreichischen Akademie der Wissenschaften

nachricht Toward a 'smart' patch that automatically delivers insulin when needed
18.01.2017 | American Chemical Society

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: How gut bacteria can make us ill

HZI researchers decipher infection mechanisms of Yersinia and immune responses of the host

Yersiniae cause severe intestinal infections. Studies using Yersinia pseudotuberculosis as a model organism aim to elucidate the infection mechanisms of these...

Im Focus: Interfacial Superconductivity: Magnetic and superconducting order revealed simultaneously

Researchers from the University of Hamburg in Germany, in collaboration with colleagues from the University of Aarhus in Denmark, have synthesized a new superconducting material by growing a few layers of an antiferromagnetic transition-metal chalcogenide on a bismuth-based topological insulator, both being non-superconducting materials.

While superconductivity and magnetism are generally believed to be mutually exclusive, surprisingly, in this new material, superconducting correlations...

Im Focus: Studying fundamental particles in materials

Laser-driving of semimetals allows creating novel quasiparticle states within condensed matter systems and switching between different states on ultrafast time scales

Studying properties of fundamental particles in condensed matter systems is a promising approach to quantum field theory. Quasiparticles offer the opportunity...

Im Focus: Designing Architecture with Solar Building Envelopes

Among the general public, solar thermal energy is currently associated with dark blue, rectangular collectors on building roofs. Technologies are needed for aesthetically high quality architecture which offer the architect more room for manoeuvre when it comes to low- and plus-energy buildings. With the “ArKol” project, researchers at Fraunhofer ISE together with partners are currently developing two façade collectors for solar thermal energy generation, which permit a high degree of design flexibility: a strip collector for opaque façade sections and a solar thermal blind for transparent sections. The current state of the two developments will be presented at the BAU 2017 trade fair.

As part of the “ArKol – development of architecturally highly integrated façade collectors with heat pipes” project, Fraunhofer ISE together with its partners...

Im Focus: How to inflate a hardened concrete shell with a weight of 80 t

At TU Wien, an alternative for resource intensive formwork for the construction of concrete domes was developed. It is now used in a test dome for the Austrian Federal Railways Infrastructure (ÖBB Infrastruktur).

Concrete shells are efficient structures, but not very resource efficient. The formwork for the construction of concrete domes alone requires a high amount of...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

12V, 48V, high-voltage – trends in E/E automotive architecture

10.01.2017 | Event News

2nd Conference on Non-Textual Information on 10 and 11 May 2017 in Hannover

09.01.2017 | Event News

Nothing will happen without batteries making it happen!

05.01.2017 | Event News

 
Latest News

A big nano boost for solar cells

18.01.2017 | Power and Electrical Engineering

Glass's off-kilter harmonies

18.01.2017 | Materials Sciences

Toward a 'smart' patch that automatically delivers insulin when needed

18.01.2017 | Life Sciences

VideoLinks
B2B-VideoLinks
More VideoLinks >>>