Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Gene variant linked with development of COPD in men

16.05.2011
Researchers have linked a variant in the vitamin D receptor gene (VDR) with the onset of chronic obstructive pulmonary disease (COPD) in Caucasian men. The study population consisted of participants in the Veterans Administration Normative Aging Study, a multidisciplinary study of aging that began in 1963.

The VDR study will be presented at the ATS 2011 International Conference.

"Our results show that this gene variant is associated with development of COPD in Caucasian men, and provides support for the notion that vitamin D metabolic pathways may affect COPD risk," said Audrey Poon, PhD, postdoctoral fellow at Meakins-Christie Laboratories, McGill University Health Centre in Montreal. The study was conducted while Dr. Poon was doing her first postdoctoral fellowship at Channing Laboratory, Brigham and Women's Hospital in Boston.

Although cigarette smoking is considered to be the main risk factor for chronic obstructive diseases such as emphysema and chronic bronchitis, only a proportion of smokers develop clinical disease. Researchers believe genetic factors also contribute to the risk of developing COPD. The vitamin D metabolic pathway has been implicated in the development of COPD.

"Several variants of genes that control vitamin D function and metabolism have been associated with COPD and other lung diseases, but results have been conflicting," Dr. Poon said. "In this study we investigated variants in two vitamin D pathway genes and their association with development of COPD."

Using DNA data from the VA study, the researchers determined the genotypes of 24 variants in the vitamin D receptor gene and 12 in the vitamin D binding protein gene in a total of 1,215 men. All subjects were free of known chronic conditions, including coronary heart disease, hypertension, chronic lung disease, asthma and diabetes at the time of recruitment.The VA study also offered data from repeated lung function measures conducted over 40 years, as well as smoking information for the participants.

The researchers used the lung function data to measure the time it took for participants to develop COPD, evaluating all 36 gene variants. They found variant rs3847987 of the VDR gene was found to influence the time to onset of COPD in the study population.

"We had the expectation that we would find an association of variants in one of these genes with the development of COPD," Dr. Poon said. "However, we did not expect that this particular variant in the VDR gene would be associated, since it has not been reported to be associated with COPD before."

Future studies will need to clearly determine the function of the gene variant, she added.

"More questions need to be answered before we can take any of these findings to clinical practice," Dr. Poon said. "For instance, we do not know what effect, if any, vitamin D levels would have on the risk of developing COPD and whether circulating vitamin D levels interact with genetic variants.

"Furthermore, we only selected two genes in the pathway, and there are numerous genes that are involved," she added. "If these findings are validated, then investigating the effect of this particular variant in the function of the vitamin D receptor will be important."

"A Variant In The Vitamin D Receptor Gene (VDR) Is Associated With Time To Onset Of Chronic Obstructive Pulmonary Disease (COPD) In Men" (Session B26, Monday, May 16, 8:15-10:45 a.m., Room 603 (Street Level), Colorado Convention Center; Abstract 17371)

* Please note that numbers in this release may differ slightly from those in the abstract. Many of these investigations are ongoing; the release represents the most up-to-date data available at press time.

Keely Savoie | EurekAlert!
Further information:
http://www.thoracic.org

More articles from Life Sciences:

nachricht Multi-institutional collaboration uncovers how molecular machines assemble
02.12.2016 | Salk Institute

nachricht Fertilized egg cells trigger and monitor loss of sperm’s epigenetic memory
02.12.2016 | IMBA - Institut für Molekulare Biotechnologie der Österreichischen Akademie der Wissenschaften GmbH

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Novel silicon etching technique crafts 3-D gradient refractive index micro-optics

A multi-institutional research collaboration has created a novel approach for fabricating three-dimensional micro-optics through the shape-defined formation of porous silicon (PSi), with broad impacts in integrated optoelectronics, imaging, and photovoltaics.

Working with colleagues at Stanford and The Dow Chemical Company, researchers at the University of Illinois at Urbana-Champaign fabricated 3-D birefringent...

Im Focus: Quantum Particles Form Droplets

In experiments with magnetic atoms conducted at extremely low temperatures, scientists have demonstrated a unique phase of matter: The atoms form a new type of quantum liquid or quantum droplet state. These so called quantum droplets may preserve their form in absence of external confinement because of quantum effects. The joint team of experimental physicists from Innsbruck and theoretical physicists from Hannover report on their findings in the journal Physical Review X.

“Our Quantum droplets are in the gas phase but they still drop like a rock,” explains experimental physicist Francesca Ferlaino when talking about the...

Im Focus: MADMAX: Max Planck Institute for Physics takes up axion research

The Max Planck Institute for Physics (MPP) is opening up a new research field. A workshop from November 21 - 22, 2016 will mark the start of activities for an innovative axion experiment. Axions are still only purely hypothetical particles. Their detection could solve two fundamental problems in particle physics: What dark matter consists of and why it has not yet been possible to directly observe a CP violation for the strong interaction.

The “MADMAX” project is the MPP’s commitment to axion research. Axions are so far only a theoretical prediction and are difficult to detect: on the one hand,...

Im Focus: Molecules change shape when wet

Broadband rotational spectroscopy unravels structural reshaping of isolated molecules in the gas phase to accommodate water

In two recent publications in the Journal of Chemical Physics and in the Journal of Physical Chemistry Letters, researchers around Melanie Schnell from the Max...

Im Focus: Fraunhofer ISE Develops Highly Compact, High Frequency DC/DC Converter for Aviation

The efficiency of power electronic systems is not solely dependent on electrical efficiency but also on weight, for example, in mobile systems. When the weight of relevant components and devices in airplanes, for instance, is reduced, fuel savings can be achieved and correspondingly greenhouse gas emissions decreased. New materials and components based on gallium nitride (GaN) can help to reduce weight and increase the efficiency. With these new materials, power electronic switches can be operated at higher switching frequency, resulting in higher power density and lower material costs.

Researchers at the Fraunhofer Institute for Solar Energy Systems ISE together with partners have investigated how these materials can be used to make power...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

ICTM Conference 2017: Production technology for turbomachine manufacturing of the future

16.11.2016 | Event News

Innovation Day Laser Technology – Laser Additive Manufacturing

01.11.2016 | Event News

#IC2S2: When Social Science meets Computer Science - GESIS will host the IC2S2 conference 2017

14.10.2016 | Event News

 
Latest News

UTSA study describes new minimally invasive device to treat cancer and other illnesses

02.12.2016 | Medical Engineering

Plasma-zapping process could yield trans fat-free soybean oil product

02.12.2016 | Agricultural and Forestry Science

What do Netflix, Google and planetary systems have in common?

02.12.2016 | Physics and Astronomy

VideoLinks
B2B-VideoLinks
More VideoLinks >>>