The conclusion must be that there is no support for the previous theory regarding compensatory mechanisms in non-carriers of the T allele. Instead the new findings indicate that the KIBRA gene plays a role in memory by improving the hippocampus function in carriers of the T allele.
In a study published in Science in 2006 the entire genome was screened (in a so-called Genome-wide association study) for genetic variations of importance to episodic memory (Papassotiropoulos et al., 2006). Individuals who carried the T allele (CT or TT genotype) in a common C/T polymorphism in the KIBRA gene had better episodic memory than non-carriers of the T allele (CC genotype). In the same study, brain activity was examined during a memory task in 30 subjects with the help of a magnetic camera (fMRI). It was found that non-carriers of the T allele had greater activation of the hippocampus, an area in the brain that is important for episodic memory, than did T carriers.
Since the groups had the same memory performance, the results were explained as indicating that non-carriers needed to compensate for their poorer memory function with increased activation of the hippocampus in order to reach the same level of performance as T carriers. Increased activation in the hippocampus is strongly associated with positive aspects of the memory function, and with other genes related to memory the opposite has been observed: increased hippocampus activation in carriers of a gene variant that is associated with better memory (e.g. Hariri et al., 2003). In those cases a reasonable explanation has been that the gene is important for memory via a favorable effect on the hippocampus function.Improved memory performance in carriers of the KIBRA T allele has been verified in several subsequent studies (e.g. Bates et. al., 2009, Preuschhof et al., 2010), but since the 2006 Science article, this is the first to study KIBRA in relation to brain activation.
For more information, please contact Karolina Kauppi email@example.com , phone: +46 (0)90-786 51 86, ext. 13, mobile: +46 (0)730-43 38 26
Bertil Born | idw
A novel socio-ecological approach helps identifying suitable wolf habitats
17.02.2017 | Universität Zürich
New, ultra-flexible probes form reliable, scar-free integration with the brain
16.02.2017 | University of Texas at Austin
Cells need to repair damaged DNA in our genes to prevent the development of cancer and other diseases. Our cells therefore activate and send “repair-proteins”...
The Fraunhofer IWS Dresden and Technische Universität Dresden inaugurated their jointly operated Center for Additive Manufacturing Dresden (AMCD) with a festive ceremony on February 7, 2017. Scientists from various disciplines perform research on materials, additive manufacturing processes and innovative technologies, which build up components in a layer by layer process. This technology opens up new horizons for component design and combinations of functions. For example during fabrication, electrical conductors and sensors are already able to be additively manufactured into components. They provide information about stress conditions of a product during operation.
The 3D-printing technology, or additive manufacturing as it is often called, has long made the step out of scientific research laboratories into industrial...
Nature does amazing things with limited design materials. Grass, for example, can support its own weight, resist strong wind loads, and recover after being...
Nanometer-scale magnetic perforated grids could create new possibilities for computing. Together with international colleagues, scientists from the Helmholtz Zentrum Dresden-Rossendorf (HZDR) have shown how a cobalt grid can be reliably programmed at room temperature. In addition they discovered that for every hole ("antidot") three magnetic states can be configured. The results have been published in the journal "Scientific Reports".
Physicist Dr. Rantej Bali from the HZDR, together with scientists from Singapore and Australia, designed a special grid structure in a thin layer of cobalt in...
13.02.2017 | Event News
10.02.2017 | Event News
09.02.2017 | Event News
17.02.2017 | Medical Engineering
17.02.2017 | Medical Engineering
17.02.2017 | Health and Medicine