When it comes to heart disease, Dr. Ross Feldman says women are often in the dark.
Historically, it was thought that heart disease was a men's-only disease, however, data has shown that post-menopausal women are just as likely as men to get heart disease and are less likely to be adequately diagnosed and treated. New research from Western University published online this week in the British Journal of Clinical Pharmacology brings to light a genetic basis for heart disease in women and helps to identify which women are more prone to heart disease.
The study, led by Dr. Feldman, a clinical pharmacologist at London Health Sciences Centre and a researcher at the Schulich School of Medicine & Dentistry's Robarts Research Institute, identifies a common gene variant in women for the G-protein coupled estrogen receptor 30 (GPER) that makes them significantly more likely to have high blood pressure, the single biggest risk factor for heart attack and stroke.
GPER, when functioning normally, is activated in part by the hormone estrogen and has been previously shown to relax the blood vessels, and in turn, lower blood pressure. This new study demonstrates that many women have a less functional form of GPER, increasing their risk of developing high blood pressure.
The research looked at the effect of expression of the GPER gene variant versus the normal GPER gene in the vascular smooth muscle cells as well as its association with blood pressure in humans. It also looked at the frequency of the gene variant in a group of women referred a tertiary care clinic at London Health Sciences Centre. The study found that women, but not men, carrying the GPER gene variant had higher blood pressure, and almost half of women who attended a hard-to-treat blood pressure clinic, where Dr. Feldman is a physician, expressed the variant. Twice as many women than men with hard to treat hypertension carried the gene.
"This is one step in understanding the effects of estrogen on heart disease, and understanding why some women are more prone to heart attack and stroke than others," Dr. Feldman said. "Our work is a step forward in developing approaches to treating heart disease in this under-appreciated group of patients." Video of Dr. Feldman discussing the research can be found at http://youtu.be/uK2-t7D1JMc
This research, conducted in collaboration with Robert Gros, Quingming Ding, Yasin Husssain, Matthew Ban, Adam McIntyre and Dr. Rob Hegele, was supported through a grant from Heart and Stroke Foundation.
Crystal Mackay, Media Relations Officer, Schulich School of Medicine & Dentistry, Western University t. 519.661.2111 ext. 80387, c. 519.777.1573, firstname.lastname@example.org
About Western University and Schulich Medicine & Dentistry
Western delivers an academic experience second to none. Since 1878, The Western Experience has combined academic excellence with life-long opportunities for intellectual, social and cultural growth in order to better serve our communities.
The Schulich School of Medicine & Dentistry at Western University is one of Canada's preeminent medical and dental schools. Established in 1881, it was one of the founding schools of Western University and is known for being the birthplace of family medicine in Canada. For more than 130 years, the School has demonstrated a commitment to academic excellence and a passion for scientific discovery.
Follow Western Media Relations online:
Crystal Mackay | Eurek Alert!
Subcutaneous Administration of Multispecific Antibody Makes Tumor Treatment Faster & More Tolerable
01.07.2015 | Helmholtz Zentrum München - Deutsches Forschungszentrum für Gesundheit und Umwelt
Why human egg cells don't age well
01.07.2015 | RIKEN
New technique combines electron microscopy and synchrotron X-rays to track chemical reactions under real operating conditions
A new technique pioneered at the U.S. Department of Energy's Brookhaven National Laboratory reveals atomic-scale changes during catalytic reactions in real...
Think of an object made of iron: An I-beam, a car frame, a nail. Now imagine that half of the iron in that object owes its existence to bacteria living two and a half billion years ago.
Think of an object made of iron: An I-beam, a car frame, a nail. Now imagine that half of the iron in that object owes its existence to bacteria living two and...
A team of scientists including PhD student Friedrich Schuler from the Laboratory of MEMS Applications at the Department of Microsystems Engineering (IMTEK) of...
The three-year clinical trial results of the retinal implant popularly known as the "bionic eye," have proven the long-term efficacy, safety and reliability of...
On June 23, the second Sentinel mission was launched from the space mission launch center in Kourou. A critical component of Aachen is on board. Researchers at the Fraunhofer Institute for Laser Technology ILT and Tesat-Spacecom have jointly developed the know-how for space-qualified laser components. For the Sentinel mission the diode laser pump module of the Laser Communication Terminal LCT was planned and constructed in Aachen in cooperation with the manufacturer of the LCT, Tesat-Spacecom, and the Ferdinand Braun Institute.
After eight years of preparation, in the early morning of June 23 the time had come: in Kourou in French Guiana, the European Space Agency launched the...
25.06.2015 | Event News
16.06.2015 | Event News
11.06.2015 | Event News
01.07.2015 | Press release
01.07.2015 | Awards Funding
01.07.2015 | Physics and Astronomy