Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Gene therapy and the regeneration of retinal ganglion cell axons

07.07.2014

Because the adult mammalian central nervous system has only limited intrinsic capacity to regenerate connections after injury, due to factors both intrinsic and extrinsic to the mature neuron, therapies are required to support the survival of injured neurons and to promote the long-distance regrowth of axons back to their original target structures.

The retina and optic nerve are part of the CNS and this system is much used in experiments designed to test new ways of promoting regeneration after injury.

Testing of therapies designed to improve RGCs viability also has direct clinical relevance because there is loss of these centrally projecting neurons in many ophthalmic diseases.

Many different approaches are being trialed, targeting different receptor systems and/or different signaling pathways, some aimed at enhancing intrinsic growth capacity in injured RGCs, others aimed at reducing the impact of factors external to the neuron that suppress/restrict the regenerative response.

An approach increasingly of interest involves the use of modified, replication-deficient viral vectors to introduce appropriate genes into injured cells in the visual pathway (gene therapy).

In the perspective article written by Prof Alan Harvey, from School of Anatomy, Physiology and Human Biology, The University of Western Australia, he summarized recent gene therapy research from his laboratory, using the rodent visual system as an experimental model, which is aimed at improving both the viability and regenerative capacity of injured adult RGCs.

These perspectives were published in the Neural Regeneration Research (Vol. 9, No. 3, 2014).

Meng Zhao | Eurek Alert!
Further information:
http://www.nrren.org

Further reports about: Anatomy Physiology Regeneration axons diseases experimental injury neurons receptor regenerative retinal therapy vectors

More articles from Life Sciences:

nachricht Retracing the Roots of Fungal Symbioses
27.02.2015 | Lawrence Berkeley National Laboratory

nachricht Moving molecule writes letters
27.02.2015 | Technische Universitaet Muenchen

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Anzeige

Anzeige

Event News

European Geosciences Union meeting: programme online, provisional press conference topics

26.02.2015 | Event News

Round Table on Solar Energy Research

18.02.2015 | Event News

40th FEBS Congress 2015 – The Biochemical Basis of Life

09.02.2015 | Event News

 
Latest News

Researchers create self-reconstructive metal wire utilizing electric field trapping of gold nanoparticles

27.02.2015 | Power and Electrical Engineering

Climate-Change Clues From the Turtles of Tropical Wyoming

27.02.2015 | Ecology, The Environment and Conservation

Pockets of Calm Protect Molecules Around a Supermassive Black Hole

27.02.2015 | Physics and Astronomy

VideoLinks
B2B-VideoLinks
More VideoLinks >>>