Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Gene therapy and the regeneration of retinal ganglion cell axons

07.07.2014

Because the adult mammalian central nervous system has only limited intrinsic capacity to regenerate connections after injury, due to factors both intrinsic and extrinsic to the mature neuron, therapies are required to support the survival of injured neurons and to promote the long-distance regrowth of axons back to their original target structures.

The retina and optic nerve are part of the CNS and this system is much used in experiments designed to test new ways of promoting regeneration after injury.

Testing of therapies designed to improve RGCs viability also has direct clinical relevance because there is loss of these centrally projecting neurons in many ophthalmic diseases.

Many different approaches are being trialed, targeting different receptor systems and/or different signaling pathways, some aimed at enhancing intrinsic growth capacity in injured RGCs, others aimed at reducing the impact of factors external to the neuron that suppress/restrict the regenerative response.

An approach increasingly of interest involves the use of modified, replication-deficient viral vectors to introduce appropriate genes into injured cells in the visual pathway (gene therapy).

In the perspective article written by Prof Alan Harvey, from School of Anatomy, Physiology and Human Biology, The University of Western Australia, he summarized recent gene therapy research from his laboratory, using the rodent visual system as an experimental model, which is aimed at improving both the viability and regenerative capacity of injured adult RGCs.

These perspectives were published in the Neural Regeneration Research (Vol. 9, No. 3, 2014).

Meng Zhao | Eurek Alert!
Further information:
http://www.nrren.org

Further reports about: Anatomy Physiology Regeneration axons diseases experimental injury neurons receptor regenerative retinal therapy vectors

More articles from Life Sciences:

nachricht A Fluttering Accordion
04.08.2015 | Friedrich-Schiller-Universität Jena

nachricht Molecular Spies to Fight Cancer - Procedure for improving tumor diagnosis successfully tested
03.08.2015 | Helmholtz-Zentrum Dresden-Rossendorf

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Greenhouse gases' millennia-long ocean legacy

Continuing current carbon dioxide (CO2) emission trends throughout this century and beyond would leave a legacy of heat and acidity in the deep ocean. These...

Im Focus: Glaciers melt faster than ever

Glacier decline in the first decade of the 21st century has reached a historical record, since the onset of direct observations. Glacier melt is a global phenomenon and will continue even without further climate change. This is shown in the latest study by the World Glacier Monitoring Service under the lead of the University of Zurich, Switzerland.

The World Glacier Monitoring Service, domiciled at the University of Zurich, has compiled worldwide data on glacier changes for more than 120 years. Together...

Im Focus: Quantum Matter Stuck in Unrest

Using ultracold atoms trapped in light crystals, scientists from the MPQ, LMU, and the Weizmann Institute observe a novel state of matter that never thermalizes.

What happens if one mixes cold and hot water? After some initial dynamics, one is left with lukewarm water—the system has thermalized to a new thermal...

Im Focus: On the crest of the wave: Electronics on a time scale shorter than a cycle of light

Physicists from Regensburg and Marburg, Germany have succeeded in taking a slow-motion movie of speeding electrons in a solid driven by a strong light wave. In the process, they have unraveled a novel quantum phenomenon, which will be reported in the forthcoming edition of Nature.

The advent of ever faster electronics featuring clock rates up to the multiple-gigahertz range has revolutionized our day-to-day life. Researchers and...

Im Focus: Superfast fluorescence sets new speed record

Plasmonic device has speed and efficiency to serve optical computers

Researchers have developed an ultrafast light-emitting device that can flip on and off 90 billion times a second and could form the basis of optical computing.

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

Success 4.0 – Is Your Company Fit for the Future? New Series of Events for Executives

04.08.2015 | Event News

3rd Euro Bio-inspired - International Conference and Exhibition on Bio-inspired Materials

23.07.2015 | Event News

Clash of Realities – International Conference on the Art, Technology and Theory of Digital Games

10.07.2015 | Event News

 
Latest News

Small tilt in magnets makes them viable memory chips

04.08.2015 | Information Technology

New Design Brings World’s First Solar Battery to Performance Milestone

04.08.2015 | Power and Electrical Engineering

Magnetism at Nanoscale

04.08.2015 | Materials Sciences

VideoLinks
B2B-VideoLinks
More VideoLinks >>>