Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Gene therapy and the regeneration of retinal ganglion cell axons

07.07.2014

Because the adult mammalian central nervous system has only limited intrinsic capacity to regenerate connections after injury, due to factors both intrinsic and extrinsic to the mature neuron, therapies are required to support the survival of injured neurons and to promote the long-distance regrowth of axons back to their original target structures.

The retina and optic nerve are part of the CNS and this system is much used in experiments designed to test new ways of promoting regeneration after injury.

Testing of therapies designed to improve RGCs viability also has direct clinical relevance because there is loss of these centrally projecting neurons in many ophthalmic diseases.

Many different approaches are being trialed, targeting different receptor systems and/or different signaling pathways, some aimed at enhancing intrinsic growth capacity in injured RGCs, others aimed at reducing the impact of factors external to the neuron that suppress/restrict the regenerative response.

An approach increasingly of interest involves the use of modified, replication-deficient viral vectors to introduce appropriate genes into injured cells in the visual pathway (gene therapy).

In the perspective article written by Prof Alan Harvey, from School of Anatomy, Physiology and Human Biology, The University of Western Australia, he summarized recent gene therapy research from his laboratory, using the rodent visual system as an experimental model, which is aimed at improving both the viability and regenerative capacity of injured adult RGCs.

These perspectives were published in the Neural Regeneration Research (Vol. 9, No. 3, 2014).

Meng Zhao | Eurek Alert!
Further information:
http://www.nrren.org

Further reports about: Anatomy Physiology Regeneration axons diseases experimental injury neurons receptor regenerative retinal therapy vectors

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Anzeige

Anzeige

Event News

Registration Open Now: 18th International ESAFORM Conference on Material Forming

28.10.2014 | Event News

Comparing Apples and Oranges? A Colloquium on International Comparative Urban Research

22.10.2014 | Event News

Battery Conference April 2015 in Aachen

16.10.2014 | Event News

 
Latest News

NIST 'combs' the atmosphere to measure greenhouse gases

30.10.2014 | Earth Sciences

First detailed picture of a cancer-related cell enzyme in action on a chromosome unit

30.10.2014 | Life Sciences

High-intensity sound waves may aid regenerative medicine

30.10.2014 | Health and Medicine

VideoLinks
B2B-VideoLinks
More VideoLinks >>>