Hair is important for temperature regulation, physical protection, sensory activity, seasonal camouflage, and social interactions. Hair is formed in hair follicles, which are complex mini-organs in the skin that are specialized for this purpose.
All hair follicles are formed during fetal development, then new hair is generated in the hair follicle by continually undergoing phases of recession, rest, and growth throughout life. The length of the hair is determined by the duration of the growth phase; for example, the growth phase for scalp hair can proceed for a number of years, while the growth phase for eyebrows last a few months.
After the growth phase, hair formation ceases, and the follicle recedes and enters a period of rest. After a period of rest, a new growth period starts, and the old hair is ejected and lost from the body. The reason for this complex regulation of hair growth is not understood, but it has been suggested that it makes it possible to adjust hair growth to the season.
In the present study Leif Carlsson's research team identifies the transcription factor Lhx2 as an important regulator of hair formation. The Lhx2 gene is active during the hair follicle's growth phase and is turned off during the resting period. The scientists have been able to show that Lhx2 is functionally involved in the formation of hair, as hair follicles in which Lhx2 has been inactivated cannot produce hair. Moreover, the activation of the Lhx2 gene in hair follicles has been shown to activate the growth phase and hence the formation of hair. Thus, Lhx2 is a gene that is important for the regulation of hair growth.
In stark contrast to previously published research findings from other teams of scientists, Leif Carlsson and his colleagues found that Lhx2 is primarily expressed outside the so-called bulge region of the hair follicle, where the follicle's stem cells are found. The Umeå researchers have also shown that Lhx2 is necessary for the hair follicle's growth (anagen) phase to proceed and for the hair follicle's structuring. Moreover, transgenic expression of Lhx2 after birth is sufficient to activate the growth phase and stimulate hair growth.
These findings allow for an alternative interpretation of the function of Lhx2 in hair follicles compared with previous results. Lhx2 is expressed periodically, primarily in precursor cells that are distinct from the cells in the bulging region of the follicles. It is a factor that is necessary for hair to be formed and to grow.
Phone: +46 (0)90-785 44 36 ; Mobile: +46 (0)70-374 79 51 ; E-mail email@example.com
Pressofficer Hans Fällman; firstname.lastname@example.org; +46-70 691 28 29
Hans Fällman | idw
Make way for the mini flying machines
21.03.2018 | American Chemical Society
New 4-D printer could reshape the world we live in
21.03.2018 | American Chemical Society
In just a few weeks from now, the Chinese space station Tiangong-1 will re-enter the Earth's atmosphere where it will to a large extent burn up. It is possible that some debris will reach the Earth's surface. Tiangong-1 is orbiting the Earth uncontrolled at a speed of approx. 29,000 km/h.Currently the prognosis relating to the time of impact currently lies within a window of several days. The scientists at Fraunhofer FHR have already been monitoring Tiangong-1 for a number of weeks with their TIRA system, one of the most powerful space observation radars in the world, with a view to supporting the German Space Situational Awareness Center and the ESA with their re-entry forecasts.
Following the loss of radio contact with Tiangong-1 in 2016 and due to the low orbital height, it is now inevitable that the Chinese space station will...
Fraunhofer Institute for Organic Electronics, Electron Beam and Plasma Technology FEP, provider of research and development services for OLED lighting solutions, announces the founding of the “OLED Licht Forum” and presents latest OLED design and lighting solutions during light+building, from March 18th – 23rd, 2018 in Frankfurt a.M./Germany, at booth no. F91 in Hall 4.0.
They are united in their passion for OLED (organic light emitting diodes) lighting with all of its unique facets and application possibilities. Thus experts in...
A new scenario seeking to explain how Mars' putative oceans came and went over the last 4 billion years implies that the oceans formed several hundred million...
For the first time, an interdisciplinary team from the University of Basel has succeeded in integrating artificial organelles into the cells of live zebrafish embryos. This innovative approach using artificial organelles as cellular implants offers new potential in treating a range of diseases, as the authors report in an article published in Nature Communications.
In the cells of higher organisms, organelles such as the nucleus or mitochondria perform a range of complex functions necessary for life. In the networks of...
Animal photoreceptors capture light with photopigments. Researchers from the University of Göttingen have now discovered that these photopigments fulfill an...
19.03.2018 | Event News
16.03.2018 | Event News
13.03.2018 | Event News
21.03.2018 | Physics and Astronomy
21.03.2018 | Materials Sciences
21.03.2018 | Life Sciences