Corrected 2nd paragraph with additions
The results also highlight where gene expression can get out of control. The research was enabled by the close collaboration of a team led by the biologists Björn Schwanhäusser, Matthias Selbach, the systems biologist Jana Wolf and the biologist Wei Chen of the Berlin Institute for Medical Systems Biology (BIMSB) of the MDC (Nature doi:10.1038/nature10098)*.The Berlin Institute for Medical Systems Biology (BIMSB) was launched by the MDC in 2008, supported by start-up funding from the Federal Ministry of Education and Research (BMBF) and the Senate of Berlin. The focus of Medical Systems Biology is not on genes and their proteins as isolated components, but on their regulation and their interaction with each other and on their relevance for disease processes. Since its inception, the internationally renowned BIMSB has become a beacon in the Berlin research landscape. It works closely with other institutions in numerous research networks and participates in excellence clusters with the Berlin universities, collaborating in particular with Humboldt University and Charité – Universitätsmedizin Berlin and also with New York University.
Proteins are the major building blocks of life. “They control virtually all biological processes ranging from heartbeat and oxygen transport up to and including thinking,” Matthias Selbach explained. The blueprint for proteins is stored in the genes in the cell nucleus. The messenger RNA (mRNA) formed in the cell nucleus (transcription) brings a copy of the blueprint to the protein factories of the cell in the cytoplasm, to the ribosomes. There the information of the mRNAs is used for protein production (translation). The fundamental question was which of the two processes, i.e. transcription or translation, plays the dominant role in regulating cellular protein levels.
The starting point of the MDC researchers was to measure the turnover of cellular mRNAs and proteins and mRNA and protein levels. They used high-throughput technologies such as quantitative mass spectrometry and the latest sequencing techniques, which are available close by at the MDC / BIMSB. In total, they quantified proteins and mRNAs for more than 5,000 genes. By means of mathematical modeling, the researchers drew conclusions from the collected data about the control of protein levels. Intriguingly, they observed that cellular protein levels mainly depend on translation of mRNAs in the protein factories of the cytoplasm. “The ribosomes ultimately determine protein abundance. Some mRNAs are translated into only one protein per hour, others are translated 200 times,” Matthias Selbach said.Cells work in an energy-efficient way
The researchers hope their results will also be relevant for diseases. "So far, this is purely basic research,” Matthias Selbach stressed. "But we also know that the production of proteins is disturbed in many diseases, for example cancer." Very little is known about where the process gets out of control. Until now, researchers focused almost exclusively on the nucleus to find answers to this question. The new findings, however, show that the protein factories in the cytoplasm are of great significance. Perhaps this is where the key to understanding diseases can be found.*Global quantification of mammalian gene expression control
1Max Delbrück Center for Molecular Medicine, Robert-Rössle-Str. 10, D-13092 Berlin, Germany. 2MicroDiscovery GmbH, Marienburger Str. 1, D-10405 Berlin, Germany.Barbara Bachtler
Single-stranded DNA and RNA origami go live
15.12.2017 | Wyss Institute for Biologically Inspired Engineering at Harvard
New antbird species discovered in Peru by LSU ornithologists
15.12.2017 | Louisiana State University
DNA molecules that follow specific instructions could offer more precise molecular control of synthetic chemical systems, a discovery that opens the door for engineers to create molecular machines with new and complex behaviors.
Researchers have created chemical amplifiers and a chemical oscillator using a systematic method that has the potential to embed sophisticated circuit...
MPQ scientists achieve long storage times for photonic quantum bits which break the lower bound for direct teleportation in a global quantum network.
Concerning the development of quantum memories for the realization of global quantum networks, scientists of the Quantum Dynamics Division led by Professor...
Researchers have developed a water cloaking concept based on electromagnetic forces that could eliminate an object's wake, greatly reducing its drag while...
Tiny pores at a cell's entryway act as miniature bouncers, letting in some electrically charged atoms--ions--but blocking others. Operating as exquisitely sensitive filters, these "ion channels" play a critical role in biological functions such as muscle contraction and the firing of brain cells.
To rapidly transport the right ions through the cell membrane, the tiny channels rely on a complex interplay between the ions and surrounding molecules,...
The miniaturization of the current technology of storage media is hindered by fundamental limits of quantum mechanics. A new approach consists in using so-called spin-crossover molecules as the smallest possible storage unit. Similar to normal hard drives, these special molecules can save information via their magnetic state. A research team from Kiel University has now managed to successfully place a new class of spin-crossover molecules onto a surface and to improve the molecule’s storage capacity. The storage density of conventional hard drives could therefore theoretically be increased by more than one hundred fold. The study has been published in the scientific journal Nano Letters.
Over the past few years, the building blocks of storage media have gotten ever smaller. But further miniaturization of the current technology is hindered by...
11.12.2017 | Event News
08.12.2017 | Event News
07.12.2017 | Event News
15.12.2017 | Power and Electrical Engineering
15.12.2017 | Materials Sciences
15.12.2017 | Life Sciences