Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Gene may hold key to reducing spread of oral cancers

26.07.2010
The spread of cancer cells in the tongue may be reduced if a gene that regulates cancer cell migration can be controlled, according to new research at the University of Illinois at Chicago.

Oral cancer is an under-treated and poorly understood disease, says Xiaofeng "Charles" Zhou, assistant professor in the UIC Center for Molecular Biology of Oral Diseases and lead researcher of the study.

More than 90 percent of oral cancers are squamous cell carcinomas that normally start on the gums, floor of the mouth, or tongue. About 30,000 Americans are affected each year, Zhou said.

While new cancers of all types have risen 8 percent in the last five years, oral cancer increased 21 percent, according to the American Cancer Society. Tongue squamous cell carcinoma, one of the most frequent oral cancers, rose more than 37 percent in this period. And although overall cancer deaths decreased during this period, those due to oral cancer increased by 4 percent -- and those due to tongue squamous cell carcinoma by 10 percent.

Improvements in patient survival require better understanding of tumor invasion and how cancer spreads, Zhou said, so that aggressive tumors can be detected early and targeted therapies can be developed.

While researchers have tried to identify altered genes that contribute to the aggressive nature of tongue squamous cell carcinoma, most previous studies have focused on protein-encoding genes, Zhou said.

The new study examines a noncoding gene called microRNA-138.

MicroRNAs are small, noncoding RNA molecules that control the expression of a target gene after the intermediary message for the gene has been transcribed into RNA, Zhou said. Several microRNAs are believed to stimulate the spread of various types of cancer. The new study, he said, demonstrated that a reduced level of microRNA-138 is associated with enhanced ability of tongue squamous cell carcinoma cells to spread.

"Our knowledge of genomic aberrations associated with noncoding genes and their contributions to cancer initiation and progression is relatively limited," he said.

The study is published in the August issue of the International Journal of Cancer. It was funded by grants from the National Cancer Institute, the National Institute of Dental and Craniofacial Research, and the Prevent Cancer Foundation.

Zhou was assisted by Lu Jiang, Xiqiang Liu, Jinsheng Yu, Anxun Wang, Fei Shi and Caroline Heidbreder of the UIC Center for Molecular Biology of Oral Diseases, and Antonia Kolokythas of UIC's department of oral and maxillofacial surgery.

For more information about UIC, visit www.uic.edu.

Sam Hostettler | EurekAlert!
Further information:
http://www.uic.edu

More articles from Life Sciences:

nachricht Biofuel produced by microalgae
28.02.2017 | Tokyo Institute of Technology

nachricht Decoding the genome's cryptic language
27.02.2017 | University of California - San Diego

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Safe glide at total engine failure with ELA-inside

On January 15, 2009, Chesley B. Sullenberger was celebrated world-wide: after the two engines had failed due to bird strike, he and his flight crew succeeded after a glide flight with an Airbus A320 in ditching on the Hudson River. All 155 people on board were saved.

On January 15, 2009, Chesley B. Sullenberger was celebrated world-wide: after the two engines had failed due to bird strike, he and his flight crew succeeded...

Im Focus: Breakthrough with a chain of gold atoms

In the field of nanoscience, an international team of physicists with participants from Konstanz has achieved a breakthrough in understanding heat transport

In the field of nanoscience, an international team of physicists with participants from Konstanz has achieved a breakthrough in understanding heat transport

Im Focus: DNA repair: a new letter in the cell alphabet

Results reveal how discoveries may be hidden in scientific “blind spots”

Cells need to repair damaged DNA in our genes to prevent the development of cancer and other diseases. Our cells therefore activate and send “repair-proteins”...

Im Focus: Dresdner scientists print tomorrow’s world

The Fraunhofer IWS Dresden and Technische Universität Dresden inaugurated their jointly operated Center for Additive Manufacturing Dresden (AMCD) with a festive ceremony on February 7, 2017. Scientists from various disciplines perform research on materials, additive manufacturing processes and innovative technologies, which build up components in a layer by layer process. This technology opens up new horizons for component design and combinations of functions. For example during fabrication, electrical conductors and sensors are already able to be additively manufactured into components. They provide information about stress conditions of a product during operation.

The 3D-printing technology, or additive manufacturing as it is often called, has long made the step out of scientific research laboratories into industrial...

Im Focus: Mimicking nature's cellular architectures via 3-D printing

Research offers new level of control over the structure of 3-D printed materials

Nature does amazing things with limited design materials. Grass, for example, can support its own weight, resist strong wind loads, and recover after being...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

Booth and panel discussion – The Lindau Nobel Laureate Meetings at the AAAS 2017 Annual Meeting

13.02.2017 | Event News

Complex Loading versus Hidden Reserves

10.02.2017 | Event News

International Conference on Crystal Growth in Freiburg

09.02.2017 | Event News

 
Latest News

Scientists reach back in time to discover some of the most power-packed galaxies

28.02.2017 | Physics and Astronomy

Nano 'sandwich' offers unique properties

28.02.2017 | Materials Sciences

Light beam replaces blood test during heart surgery

28.02.2017 | Health and Medicine

VideoLinks
B2B-VideoLinks
More VideoLinks >>>