Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:


Gene may hold key to reducing spread of oral cancers

The spread of cancer cells in the tongue may be reduced if a gene that regulates cancer cell migration can be controlled, according to new research at the University of Illinois at Chicago.

Oral cancer is an under-treated and poorly understood disease, says Xiaofeng "Charles" Zhou, assistant professor in the UIC Center for Molecular Biology of Oral Diseases and lead researcher of the study.

More than 90 percent of oral cancers are squamous cell carcinomas that normally start on the gums, floor of the mouth, or tongue. About 30,000 Americans are affected each year, Zhou said.

While new cancers of all types have risen 8 percent in the last five years, oral cancer increased 21 percent, according to the American Cancer Society. Tongue squamous cell carcinoma, one of the most frequent oral cancers, rose more than 37 percent in this period. And although overall cancer deaths decreased during this period, those due to oral cancer increased by 4 percent -- and those due to tongue squamous cell carcinoma by 10 percent.

Improvements in patient survival require better understanding of tumor invasion and how cancer spreads, Zhou said, so that aggressive tumors can be detected early and targeted therapies can be developed.

While researchers have tried to identify altered genes that contribute to the aggressive nature of tongue squamous cell carcinoma, most previous studies have focused on protein-encoding genes, Zhou said.

The new study examines a noncoding gene called microRNA-138.

MicroRNAs are small, noncoding RNA molecules that control the expression of a target gene after the intermediary message for the gene has been transcribed into RNA, Zhou said. Several microRNAs are believed to stimulate the spread of various types of cancer. The new study, he said, demonstrated that a reduced level of microRNA-138 is associated with enhanced ability of tongue squamous cell carcinoma cells to spread.

"Our knowledge of genomic aberrations associated with noncoding genes and their contributions to cancer initiation and progression is relatively limited," he said.

The study is published in the August issue of the International Journal of Cancer. It was funded by grants from the National Cancer Institute, the National Institute of Dental and Craniofacial Research, and the Prevent Cancer Foundation.

Zhou was assisted by Lu Jiang, Xiqiang Liu, Jinsheng Yu, Anxun Wang, Fei Shi and Caroline Heidbreder of the UIC Center for Molecular Biology of Oral Diseases, and Antonia Kolokythas of UIC's department of oral and maxillofacial surgery.

For more information about UIC, visit

Sam Hostettler | EurekAlert!
Further information:

More articles from Life Sciences:

nachricht Don't Give the Slightest Chance to Toxic Elements in Medicinal Products
23.03.2018 | Physikalisch-Technische Bundesanstalt (PTB)

nachricht North and South Cooperation to Combat Tuberculosis
22.03.2018 | Universität Zürich

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Space observation with radar to secure Germany's space infrastructure

Satellites in near-Earth orbit are at risk due to the steady increase in space debris. But their mission in the areas of telecommunications, navigation or weather forecasts is essential for society. Fraunhofer FHR therefore develops radar-based systems which allow the detection, tracking and cataloging of even the smallest particles of debris. Satellite operators who have access to our data are in a better position to plan evasive maneuvers and prevent destructive collisions. From April, 25-29 2018, Fraunhofer FHR and its partners will exhibit the complementary radar systems TIRA and GESTRA as well as the latest radar techniques for space observation across three stands at the ILA Berlin.

The "traffic situation" in space is very tense: the Earth is currently being orbited not only by countless satellites but also by a large volume of space...

Im Focus: Researchers Discover New Anti-Cancer Protein

An international team of researchers has discovered a new anti-cancer protein. The protein, called LHPP, prevents the uncontrolled proliferation of cancer cells in the liver. The researchers led by Prof. Michael N. Hall from the Biozentrum, University of Basel, report in “Nature” that LHPP can also serve as a biomarker for the diagnosis and prognosis of liver cancer.

The incidence of liver cancer, also known as hepatocellular carcinoma, is steadily increasing. In the last twenty years, the number of cases has almost doubled...

Im Focus: Researchers at Fraunhofer monitor re-entry of Chinese space station Tiangong-1

In just a few weeks from now, the Chinese space station Tiangong-1 will re-enter the Earth's atmosphere where it will to a large extent burn up. It is possible that some debris will reach the Earth's surface. Tiangong-1 is orbiting the Earth uncontrolled at a speed of approx. 29,000 km/h.Currently the prognosis relating to the time of impact currently lies within a window of several days. The scientists at Fraunhofer FHR have already been monitoring Tiangong-1 for a number of weeks with their TIRA system, one of the most powerful space observation radars in the world, with a view to supporting the German Space Situational Awareness Center and the ESA with their re-entry forecasts.

Following the loss of radio contact with Tiangong-1 in 2016 and due to the low orbital height, it is now inevitable that the Chinese space station will...

Im Focus: Alliance „OLED Licht Forum“ – Key partner for OLED lighting solutions

Fraunhofer Institute for Organic Electronics, Electron Beam and Plasma Technology FEP, provider of research and development services for OLED lighting solutions, announces the founding of the “OLED Licht Forum” and presents latest OLED design and lighting solutions during light+building, from March 18th – 23rd, 2018 in Frankfurt a.M./Germany, at booth no. F91 in Hall 4.0.

They are united in their passion for OLED (organic light emitting diodes) lighting with all of its unique facets and application possibilities. Thus experts in...

Im Focus: Mars' oceans formed early, possibly aided by massive volcanic eruptions

Oceans formed before Tharsis and evolved together, shaping climate history of Mars

A new scenario seeking to explain how Mars' putative oceans came and went over the last 4 billion years implies that the oceans formed several hundred million...

All Focus news of the innovation-report >>>



Industry & Economy
Event News

New solar solutions for sustainable buildings and cities

23.03.2018 | Event News

Virtual reality conference comes to Reutlingen

19.03.2018 | Event News

Ultrafast Wireless and Chip Design at the DATE Conference in Dresden

16.03.2018 | Event News

Latest News

For graphite pellets, just add elbow grease

23.03.2018 | Materials Sciences

Unique communication strategy discovered in stem cell pathway controlling plant growth

23.03.2018 | Agricultural and Forestry Science

Sharpening the X-ray view of the nanocosm

23.03.2018 | Physics and Astronomy

Science & Research
Overview of more VideoLinks >>>