Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Gene expression changes in nasal cells may help identify lung cancer in earliest stages

16.05.2011
A simple, minimally-invasive technique using cells from the interior of the nose could help clinicians detect lung cancer in its earliest – and most treatable – stages, according to a study conducted by researchers in Boston.

The study will be presented at the ATS 2011 International Conference.

"Our data suggests that evaluating gene expression changes in nasal cells found in the interior surface of the nose may serve as a non-invasive approach for the early detection of lung cancer in smokers," said study author Christina Anderlind, MD, Instructor of medicine at Boston University Medical Center.

Lung cancer is the most common cause of cancer mortality, with an average five-year survival rate of only 15 percent. However, survival rates are highly dependent upon how advanced the cancer is when detected.

"At an early stage, the five-year survival rate is 60 percent compared to only 2 percent at a late stage," Dr. Anderlind noted. "Despite this fact, early diagnosis is hard to achieve since the diagnostic tests currently available are highly invasive, such as open lung biopsy. We wanted to determine if a minimally invasive site like the nose could be used to diagnose cancer in its early stages, when there is a much greater chance of long-term survival."

For their study, the researchers collected nasal epithelial cells from thirty three smokers who were undergoing medically-indicated bronchoscopies for suspicion of lung cancer. Of these patients, eleven were found to have benign disease and twenty two had lung cancer. Brushings were taken from the right or left nostril and profiled on microarrays, a process that allows researchers to study gene expression changes.

"Microarrays allow us to get a detailed portrait of the expression levels of a large number of genes simultaneously, with our goal being to then sort through all these expression levels to find genes that differ in their expression between patients with lung cancer and those with benign disease," Dr. Anderlind said.

The researchers identified 170 genes that were differentially expressed between patients with and without lung cancer. They also found that genes linked to colon cancer and adenocarcinoma, as well as genes that trigger cell division and blood vessel growth, were expressed more heavily in patients with cancer. Genes involved in tumor suppression were also expressed at lower levels in these patients.

Earlier studies have used gene expression differences in the bronchial airways to identify lung cancer in its early stages. Dr. Anderlind said she and her colleagues relied on those results to design the current study.

"In this study we used the same principle as we used in our earlier studies of bronchial tissue, only this time, those methods were used to study nasal cells," she said. "Our hypothesis was that the upper airway epithelium of smokers with lung cancer displays a cancer-specific gene expression pattern, and that this airway nasal gene expression signature reflects the changes that occur in lung tissue."

Dr. Anderlind said the results of the current study are an initial indication that simple nasal brushings could offer an alternative to lung biopsy and other invasive techniques aimed at identifying lung cancer in its early stages.

"This study is a pilot study and our results are preliminary," she said. "Although we did have some indication based on previous studies that we might find gene expression changes in nasal cells, it was unexpected that normal-looking airway cells located at a distance from the lungs would show a specific gene signature that distinguishes patients with cancer from those with benign disease," she said.

A larger study funded by the National Cancer Institute's Early Detection Research Network (EDRN) in collaboration with Steven Dubinett and David Elashoff at UCLA and with Allegro Diagnostics Inc, is planned to confirm the results, she noted.

"The development of a nasal biomarker for diagnosis of lung cancer would make early diagnosis of lung cancer more feasible, allowing patients with radiographic findings that are suspicious for lung cancer to be evaluated in the clinic with nose brushings," Dr. Anderlind said. "We are planning to analyze at least 100 more samples from patients with benign disease and lung cancer, to be able to validate our results and to work toward the development of a nasal biomarker for early detection of lung cancer."

"Gene Expression Profiles In Nasal Epithelium Differ Between Smokers With And Without Lung Cancer" (Session A18, Sunday, May 15, 8:15-10:45 a.m.,Korbel Ballroom 2A-3A (Lower Level), Colorado Convention Center; Abstract 19736)

* Please note that numbers in this release may differ slightly from those in the abstract. Many of these investigations are ongoing; the release represents the most up-to-date data available at press time.

Keely Savoie | EurekAlert!
Further information:
http://www.thoracic.org

More articles from Life Sciences:

nachricht Toward a 'smart' patch that automatically delivers insulin when needed
18.01.2017 | American Chemical Society

nachricht 127 at one blow...
18.01.2017 | Stiftung Zoologisches Forschungsmuseum Alexander Koenig, Leibniz-Institut für Biodiversität der Tiere

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: How gut bacteria can make us ill

HZI researchers decipher infection mechanisms of Yersinia and immune responses of the host

Yersiniae cause severe intestinal infections. Studies using Yersinia pseudotuberculosis as a model organism aim to elucidate the infection mechanisms of these...

Im Focus: Interfacial Superconductivity: Magnetic and superconducting order revealed simultaneously

Researchers from the University of Hamburg in Germany, in collaboration with colleagues from the University of Aarhus in Denmark, have synthesized a new superconducting material by growing a few layers of an antiferromagnetic transition-metal chalcogenide on a bismuth-based topological insulator, both being non-superconducting materials.

While superconductivity and magnetism are generally believed to be mutually exclusive, surprisingly, in this new material, superconducting correlations...

Im Focus: Studying fundamental particles in materials

Laser-driving of semimetals allows creating novel quasiparticle states within condensed matter systems and switching between different states on ultrafast time scales

Studying properties of fundamental particles in condensed matter systems is a promising approach to quantum field theory. Quasiparticles offer the opportunity...

Im Focus: Designing Architecture with Solar Building Envelopes

Among the general public, solar thermal energy is currently associated with dark blue, rectangular collectors on building roofs. Technologies are needed for aesthetically high quality architecture which offer the architect more room for manoeuvre when it comes to low- and plus-energy buildings. With the “ArKol” project, researchers at Fraunhofer ISE together with partners are currently developing two façade collectors for solar thermal energy generation, which permit a high degree of design flexibility: a strip collector for opaque façade sections and a solar thermal blind for transparent sections. The current state of the two developments will be presented at the BAU 2017 trade fair.

As part of the “ArKol – development of architecturally highly integrated façade collectors with heat pipes” project, Fraunhofer ISE together with its partners...

Im Focus: How to inflate a hardened concrete shell with a weight of 80 t

At TU Wien, an alternative for resource intensive formwork for the construction of concrete domes was developed. It is now used in a test dome for the Austrian Federal Railways Infrastructure (ÖBB Infrastruktur).

Concrete shells are efficient structures, but not very resource efficient. The formwork for the construction of concrete domes alone requires a high amount of...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

12V, 48V, high-voltage – trends in E/E automotive architecture

10.01.2017 | Event News

2nd Conference on Non-Textual Information on 10 and 11 May 2017 in Hannover

09.01.2017 | Event News

Nothing will happen without batteries making it happen!

05.01.2017 | Event News

 
Latest News

A big nano boost for solar cells

18.01.2017 | Power and Electrical Engineering

Glass's off-kilter harmonies

18.01.2017 | Materials Sciences

Toward a 'smart' patch that automatically delivers insulin when needed

18.01.2017 | Life Sciences

VideoLinks
B2B-VideoLinks
More VideoLinks >>>