Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Gene analysis could allow the risk determination for esophageal cancer

28.12.2015

A genetic modification in the mucous membrane of the esophagus, the Barrett esophagus, can lead to esophageal cancer. If certain biomarkers are contained in these tissue alterations, so-called miDNA, these are extremely short DNA strands, it could be an indication that this preliminary stage of esophageal cancer indeed leads to cancer. This was discovered by scientists of the Gastroesophageal Tumor Unit (CCC-GET) of the Comprehensive Cancer Center (CCC) Vienna of the MedUni Vienna and the AKH Vienna in a joint study with the National Institutes of Health, USA, and the Johns Hopkins University, USA.

Esophageal cancer is the eighth most common tumor disease in the western world. A subtype, the adeno carcinoma, is the kind of cancer with the strongest relative increase during the past 10 years, namely around 600% in men and up to 380% in women.


Gene analysis could allow the risk determination for esophageal cancer

The highest risk factor for esophageal cancer is heartburn, i.e. the reflux of sour and acrid stomach liquid into the esophagus (reflux). If reflux remains untreated, it can lead to genetic changes in the mucous membrane and thus to the outbreak of the disease in the long term.

One preliminary stage of adeno carcinoma is the so-called Barrett esophagus, which also exhibits mutations in the mucous membrane. Barrett esophagus leads to esophageal cancer in 0.5% of the cases. In order to prevent a malignant development, physicians recommend the removal of this mucosal change.

Control modules for the tumor development

As not all cases of Barrett esophagus become malignant, it is important for the treating physician to know whether there are reliable indicators (so-called biomarkers) which allow the estimation of a tumor development in the still benign tissue. Sebastian Schoppmann of the University Clinic for Surgery at the MedUni Vienna and the AKH Vienna, Chief of CCC-GET and one of the managers of the study:

"In this project, we have examined the role of molecular-biological control modules for this tumor occurrence, the so-called miDNA in the affected tissue with the aid of a gene test. Our results show that the miDNA profiles of esophageal cancer are indeed different from Barrett esophagus."

Risk estimation and cost-saving disease control

The results of the study suggest that, based on the existence of specific miDNA, it is possible to estimate whether the existing change in the mucous membrane develops into a malignant disease. It would save patients from enduring the removal of the Barrett esophagus and save costs with respect to the follow-up checks of the disease.

Top cooperation

All 300 patients who participated in the study were procured from the CCC-GET unit of MedUni Vienna and AKH Vienna. Schoppmann: "The cooperation with the National Institutes of Health and the Johns Hopkins University, both extremely renowned establishments in the USA, is a great success. The cooperation not only shows the expertise we have developed during the past years, but also that it is recognized in international circles."

http://www.meduniwien.ac.at

Johannes Angerer | AlphaGalileo

More articles from Life Sciences:

nachricht Ion treatments for cardiac arrhythmia — Non-invasive alternative to catheter-based surgery
20.01.2017 | GSI Helmholtzzentrum für Schwerionenforschung GmbH

nachricht Seeking structure with metagenome sequences
20.01.2017 | DOE/Joint Genome Institute

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Traffic jam in empty space

New success for Konstanz physicists in studying the quantum vacuum

An important step towards a completely new experimental access to quantum physics has been made at University of Konstanz. The team of scientists headed by...

Im Focus: How gut bacteria can make us ill

HZI researchers decipher infection mechanisms of Yersinia and immune responses of the host

Yersiniae cause severe intestinal infections. Studies using Yersinia pseudotuberculosis as a model organism aim to elucidate the infection mechanisms of these...

Im Focus: Interfacial Superconductivity: Magnetic and superconducting order revealed simultaneously

Researchers from the University of Hamburg in Germany, in collaboration with colleagues from the University of Aarhus in Denmark, have synthesized a new superconducting material by growing a few layers of an antiferromagnetic transition-metal chalcogenide on a bismuth-based topological insulator, both being non-superconducting materials.

While superconductivity and magnetism are generally believed to be mutually exclusive, surprisingly, in this new material, superconducting correlations...

Im Focus: Studying fundamental particles in materials

Laser-driving of semimetals allows creating novel quasiparticle states within condensed matter systems and switching between different states on ultrafast time scales

Studying properties of fundamental particles in condensed matter systems is a promising approach to quantum field theory. Quasiparticles offer the opportunity...

Im Focus: Designing Architecture with Solar Building Envelopes

Among the general public, solar thermal energy is currently associated with dark blue, rectangular collectors on building roofs. Technologies are needed for aesthetically high quality architecture which offer the architect more room for manoeuvre when it comes to low- and plus-energy buildings. With the “ArKol” project, researchers at Fraunhofer ISE together with partners are currently developing two façade collectors for solar thermal energy generation, which permit a high degree of design flexibility: a strip collector for opaque façade sections and a solar thermal blind for transparent sections. The current state of the two developments will be presented at the BAU 2017 trade fair.

As part of the “ArKol – development of architecturally highly integrated façade collectors with heat pipes” project, Fraunhofer ISE together with its partners...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

Sustainable Water use in Agriculture in Eastern Europe and Central Asia

19.01.2017 | Event News

12V, 48V, high-voltage – trends in E/E automotive architecture

10.01.2017 | Event News

2nd Conference on Non-Textual Information on 10 and 11 May 2017 in Hannover

09.01.2017 | Event News

 
Latest News

Helmholtz International Fellow Award for Sarah Amalia Teichmann

20.01.2017 | Awards Funding

An innovative high-performance material: biofibers made from green lacewing silk

20.01.2017 | Materials Sciences

Ion treatments for cardiac arrhythmia — Non-invasive alternative to catheter-based surgery

20.01.2017 | Life Sciences

VideoLinks
B2B-VideoLinks
More VideoLinks >>>