Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Fruit Fly's Response to Starvation Could Help Control Human Appetites

04.04.2011
Biologists at UC San Diego have identified the molecular mechanisms triggered by starvation in fruit flies that enhance the nervous system’s response to smell, allowing these insects and presumably vertebrates—including humans—to become more efficient and voracious foragers when hungry.

Their discovery of the neural changes that control odor-driven food searches in flies, which they detail in a paper in the April 1 issue of the journal Cell, could provide a new way to potentially regulate human appetite.

By developing drugs to enhance or minimize the activity of nerve-signaling chemicals called neuropeptides released during starvation to enhance the sense of smell, scientists may be able to decrease the propensity among obese individuals to overeat when encountering delectable food odors, if similar molecular mechanisms exist in humans. They could also increase the appetites among the infirm, elderly and others who may have problems eating enough. The method could even be used to improve the growth of farmed animals or to reduce feed waste.

“Olfaction makes important contributions to the perception of food quality and profoundly influences our dietary choices,” said Jing Wang, an associate professor of biology at UC San Diego who headed the research effort. His team identified a neuropeptide and a receptor neuron controlling the olfactory behavior in the fly that could be targeted by drugs to effect changes in appetite that are normally regulated by an organism’s insulin levels, which changes radically when organisms are satiated or starved.

“Our studies in Drosophila address an important question—how starvation modulates olfactory processing,” he added. “We were surprised to find that starvation modulation of smell happens at the periphery, because most of the literature on feeding regulations is about the function of the hypothalamus. There are hints to suggest that this kind of starvation modulation in the peripheral olfactory system is present in vertebrate systems as well.”

While scientists had previously identified similar neuropeptides that control feeding behavior in vertebrates, not much was known until now about how these molecules control olfaction or an organism’s behavior. Researchers had previously found that the injection into the hypothalamus of insulin, the hormone that regulates blood glucose levels, reduces food intake in rodents, for example, but how insulin affects olfactory circuits in a way that altered an organism’s behavior was not well understood.

Wang and his team of UCSD biologists—Cory Root, Kang Ko and Amir Jafari—believed that by looking at the molecular mechanisms that enable fruit flies to improve their search for food when their insulin levels were low following a period of starvation the scientists would obtain a better understanding of this process. They used a computerized system to monitor over time the position of starved or well-fed flies as the flies circled around a droplet of apple cider vinegar, which served as a delectable food source.

“During the 10 min observation period,” the researchers wrote in their paper, “starved flies spend most of the time walking near the food source, whereas fed flies wander in the entire arena with a preference for the perimeter.”

The researchers found that surgical removal of the antennae used by the flies to sense odor destroyed the propensity of starved flies to hone in on the food source as did genetically suppressing the production of short neuropeptide F receptors, which the scientists found, increases in response to starvation or a drop in insulin levels. Using two-photon microscopy, a state-of-the-art imaging system, the researchers found starvation-dependent changes of olfactory response in specific neurons.

“The notion that starvation modulation at the peripheral olfactory system is linked to insulin signaling has potential implications for the therapeutic intervention of the seemingly unstoppable obesity epidemic trend in a large percentage of the population,” said Wang.

He said his team’s study has identified the insulin receptor, PI3K, and the short neuropeptide F receptor, which is also modulated by insulin levels, as potential molecular targets for controlling appetite in humans and other vertebrates. However, he added that more research is needed to know whether and to what extent insulin levels control olfactory sensitivity in human.

“Learning how olfactory neural circuits impact dietary choices is relevant towards better understanding factors that contribute to obesity and eating disorders,” he added.

Based on their findings, the UCSD biologists have filed a patent application on their discovery, contending that blocking PI3K, a signaling molecule of the insulin receptor, could improve appetites in the infirm and elderly and that the intranasal delivery of insulin could decrease appetite in obese individuals. They also contend in their patent application that suppressing PI3K will increase feeding in farmed animals and reduce feed waste.

The researchers’ work was funded by the National Institute on Deafness and Other Communication Disorders.

Kim McDonald | Newswise Science News
Further information:
http://www.ucsd.edu

More articles from Life Sciences:

nachricht Fine organic particles in the atmosphere are more often solid glass beads than liquid oil droplets
21.04.2017 | Max-Planck-Institut für Chemie

nachricht Study overturns seminal research about the developing nervous system
21.04.2017 | University of California - Los Angeles Health Sciences

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Deep inside Galaxy M87

The nearby, giant radio galaxy M87 hosts a supermassive black hole (BH) and is well-known for its bright jet dominating the spectrum over ten orders of magnitude in frequency. Due to its proximity, jet prominence, and the large black hole mass, M87 is the best laboratory for investigating the formation, acceleration, and collimation of relativistic jets. A research team led by Silke Britzen from the Max Planck Institute for Radio Astronomy in Bonn, Germany, has found strong indication for turbulent processes connecting the accretion disk and the jet of that galaxy providing insights into the longstanding problem of the origin of astrophysical jets.

Supermassive black holes form some of the most enigmatic phenomena in astrophysics. Their enormous energy output is supposed to be generated by the...

Im Focus: A Quantum Low Pass for Photons

Physicists in Garching observe novel quantum effect that limits the number of emitted photons.

The probability to find a certain number of photons inside a laser pulse usually corresponds to a classical distribution of independent events, the so-called...

Im Focus: Microprocessors based on a layer of just three atoms

Microprocessors based on atomically thin materials hold the promise of the evolution of traditional processors as well as new applications in the field of flexible electronics. Now, a TU Wien research team led by Thomas Müller has made a breakthrough in this field as part of an ongoing research project.

Two-dimensional materials, or 2D materials for short, are extremely versatile, although – or often more precisely because – they are made up of just one or a...

Im Focus: Quantum-physical Model System

Computer-assisted methods aid Heidelberg physicists in reproducing experiment with ultracold atoms

Two researchers at Heidelberg University have developed a model system that enables a better understanding of the processes in a quantum-physical experiment...

Im Focus: Glacier bacteria’s contribution to carbon cycling

Glaciers might seem rather inhospitable environments. However, they are home to a diverse and vibrant microbial community. It’s becoming increasingly clear that they play a bigger role in the carbon cycle than previously thought.

A new study, now published in the journal Nature Geoscience, shows how microbial communities in melting glaciers contribute to the Earth’s carbon cycle, a...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

Expert meeting “Health Business Connect” will connect international medical technology companies

20.04.2017 | Event News

Wenn der Computer das Gehirn austrickst

18.04.2017 | Event News

7th International Conference on Crystalline Silicon Photovoltaics in Freiburg on April 3-5, 2017

03.04.2017 | Event News

 
Latest News

New quantum liquid crystals may play role in future of computers

21.04.2017 | Physics and Astronomy

A promising target for kidney fibrosis

21.04.2017 | Health and Medicine

Light rays from a supernova bent by the curvature of space-time around a galaxy

21.04.2017 | Physics and Astronomy

VideoLinks
B2B-VideoLinks
More VideoLinks >>>