"This is new because we have direct evidence that the pheromones produced at these different ages affect sexual attractiveness differently," said Tsung-Han Kuo, a graduate student in the department of molecular and human genetics and the Huffington Center on Aging at BCM. Kuo is first author of the report that appears online in the Journal of Experimental Biology.
Pheromones are chemicals produced by an organism to communicate or attract another. In this case, Drosophila melanogaster or fruit flies produce chemicals called cuticular hydrocarbons. Special mass spectrometry studies that looked in detail at the composition and level of production of these hydrocarbons showed that they differed between the sexes, but more important, they changed with age.
"In fact, cuticular hydrocarbon production may be an indicator of the insect's health and fertility," said Kuo. Reproduction is one of the major activities of the short-lived insects, and they enhance the possibility of passing on their genes through the production of these pheromones. Unfortunately, the alluring effect of the chemicals wanes with age.
"The results were remarkably consistent across different strains of flies," said Dr. Scott Pletcher, now of the University of Michigan, and Kuo's initial mentor at BCM.
Kuo, Pletcher and Dr. Herman A. Dierick, assistant professor of molecular and human genetics at BCM, then determined how the pheromones produced at different ages affected the attractiveness of the fruit flies.
Using a specially designed holding cell, Kuo introduced a male fly into a chamber that contained two females – a young fly and an old fly. Video of the encounter showed that the male was much more attracted to the young fly.
To eliminate physical appearance from the equation, he then conducted the experiment in the dark. The males still courted the young females more vigorously. When the scientists washed the pheromones off the females' bodies, the males could no longer tell a difference between young and old.
"In the last analysis, we took the pheromone from the young and old flies and put it on flies that do not produce pheromones," said Kuo. "The flies were identical in every way but the males still preferred the flies with the 'younger' pheromone."
"We know that aging is conserved across species," said Pletcher. "We want to examine the exciting possibility that the mechanisms underlying attractiveness are also conserved across species."
Others who took part in this work include Joanne Y. Yew of the National University of Singapore, who analyzed the pheromone, Tatyana Y. Fedina of the University of Michigan and Klaus Dreisewerd of the University of Münster.
Funding for this work came from the National Institutes of Health; the Glenn Foundation; the American Federation for Aging Research; the Ellison Medical Foundation; the Alexander von Humboldt Foundation; the Singapore National Research Foundation; the National Institute of General Medical Sciences; the Drosophila Aging Core of the Nathan Shock Center of Excellence in the Biology of Aging funded by the National Institute on Aging and the National Science Foundation.
For more information on basic science research at Baylor College of Medicine, please go to www.bcm.edu/fromthelab
Glenna Picton | EurekAlert!
Symbiotic bacteria: from hitchhiker to beetle bodyguard
28.04.2017 | Johannes Gutenberg-Universität Mainz
Nose2Brain – Better Therapy for Multiple Sclerosis
28.04.2017 | Fraunhofer-Institut für Grenzflächen- und Bioverfahrenstechnik IGB
More and more automobile companies are focusing on body parts made of carbon fiber reinforced plastics (CFRP). However, manufacturing and repair costs must be further reduced in order to make CFRP more economical in use. Together with the Volkswagen AG and five other partners in the project HolQueSt 3D, the Laser Zentrum Hannover e.V. (LZH) has developed laser processes for the automatic trimming, drilling and repair of three-dimensional components.
Automated manufacturing processes are the basis for ultimately establishing the series production of CFRP components. In the project HolQueSt 3D, the LZH has...
Reflecting the structure of composites found in nature and the ancient world, researchers at the University of Illinois at Urbana-Champaign have synthesized thin carbon nanotube (CNT) textiles that exhibit both high electrical conductivity and a level of toughness that is about fifty times higher than copper films, currently used in electronics.
"The structural robustness of thin metal films has significant importance for the reliable operation of smart skin and flexible electronics including...
The nearby, giant radio galaxy M87 hosts a supermassive black hole (BH) and is well-known for its bright jet dominating the spectrum over ten orders of magnitude in frequency. Due to its proximity, jet prominence, and the large black hole mass, M87 is the best laboratory for investigating the formation, acceleration, and collimation of relativistic jets. A research team led by Silke Britzen from the Max Planck Institute for Radio Astronomy in Bonn, Germany, has found strong indication for turbulent processes connecting the accretion disk and the jet of that galaxy providing insights into the longstanding problem of the origin of astrophysical jets.
Supermassive black holes form some of the most enigmatic phenomena in astrophysics. Their enormous energy output is supposed to be generated by the...
The probability to find a certain number of photons inside a laser pulse usually corresponds to a classical distribution of independent events, the so-called...
Microprocessors based on atomically thin materials hold the promise of the evolution of traditional processors as well as new applications in the field of flexible electronics. Now, a TU Wien research team led by Thomas Müller has made a breakthrough in this field as part of an ongoing research project.
Two-dimensional materials, or 2D materials for short, are extremely versatile, although – or often more precisely because – they are made up of just one or a...
28.04.2017 | Event News
20.04.2017 | Event News
18.04.2017 | Event News
28.04.2017 | Medical Engineering
28.04.2017 | Earth Sciences
28.04.2017 | Life Sciences