Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

First French bulldog with sex reversal identified in Spain

24.03.2011
Tana, a female French bulldog, was brought to a veterinary centre for her first vaccination. Specialists there were alerted by the size of her clitoris, which was "larger than normal", and they started to carry out tests. These revealed the first ever genetic alteration ever detected in the reproductive system of this breed – the female puppy had cryptorchid testicles (outside the scrotum).

Genetic alteration of the reproductive system or sexual reversal "has been described in many species, such as goats, pigs, horses and even human beings", Marcos Campos, lead author of the study and also a researcher at the CEU-Cardenal Herrera University and director of the Reprovalcan assisted reproduction centre for small animals, tells SINC.

The puppy Tana, which was three months old when brought for her first consultation, presented symptoms compatible with having a genetic alteration of the reproductive system – she had a large clitoris. "She was a chromosomally XX female but with masculine gonads (cryptorchid testicles) due to the presence of other genes that determined the formation of testicles in the absence of the genes present on the Y chromosome", explains Campos.

This alteration, which has also been described in another 18 breeds of dog around the world, is "uncommon but it can occur". Sex reversal causes sterility and, over the long term, may predispose the animal to pathologies such as infections or tumours of the gonads, "since this is not a normal genital", the veterinarian explains.

The study, which has been published in Reproduction in Domestic Animals, showed that the urethra ended in the bladder, and the clitoris, which was 0.8 centimetres long, contained a penis bone, which predisposed it to urinary infections that would likely cause the dog to be infertile.

Canine hermaphroditism with a happy ending

The puppy, which is the first documented case anywhere in the world of a French bulldog with this alteration, had a low level of masculinisation, since despite the size of the clitoris, the vulva was normal.

To prevent Tana from suffering any medical complications, the best option was felt to be surgical sterilisation, during which her genitals were completely removed and later sent to a histopathology laboratory. "The puppy is now in perfect health", says Campos.

The veterinarians suggest that the parents of hermaphrodite puppies should be withdrawn from breeding programmes, because "it is likely that at least half of their litters will be carriers". The siblings of affected puppies should not be allowed to breed either until the mutant genes have been identified, which would make it possible to eliminate the carriers.

However, there are still no data available about the affected dogs belonging to this particular breed, which would enable the heredity model to be identified. Genetic modelling from other breeds shows that this is a autosomal recessive alteration (the animal only needs to receive the abnormal gene from one of its parents in order to inherit the sex reversal).

References:

Campos, M.; Moreno-Manzano, V.; García-Roselló, M.; García-Roselló, E. "SRY-Negative XX Sex Reversal in a French Bulldog" Reproduction in Domestic Animals 46(1): 185-188, February 2011

SINC | EurekAlert!
Further information:
http://www.plataformasinc.es

More articles from Life Sciences:

nachricht Multi-institutional collaboration uncovers how molecular machines assemble
02.12.2016 | Salk Institute

nachricht Fertilized egg cells trigger and monitor loss of sperm’s epigenetic memory
02.12.2016 | IMBA - Institut für Molekulare Biotechnologie der Österreichischen Akademie der Wissenschaften GmbH

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Novel silicon etching technique crafts 3-D gradient refractive index micro-optics

A multi-institutional research collaboration has created a novel approach for fabricating three-dimensional micro-optics through the shape-defined formation of porous silicon (PSi), with broad impacts in integrated optoelectronics, imaging, and photovoltaics.

Working with colleagues at Stanford and The Dow Chemical Company, researchers at the University of Illinois at Urbana-Champaign fabricated 3-D birefringent...

Im Focus: Quantum Particles Form Droplets

In experiments with magnetic atoms conducted at extremely low temperatures, scientists have demonstrated a unique phase of matter: The atoms form a new type of quantum liquid or quantum droplet state. These so called quantum droplets may preserve their form in absence of external confinement because of quantum effects. The joint team of experimental physicists from Innsbruck and theoretical physicists from Hannover report on their findings in the journal Physical Review X.

“Our Quantum droplets are in the gas phase but they still drop like a rock,” explains experimental physicist Francesca Ferlaino when talking about the...

Im Focus: MADMAX: Max Planck Institute for Physics takes up axion research

The Max Planck Institute for Physics (MPP) is opening up a new research field. A workshop from November 21 - 22, 2016 will mark the start of activities for an innovative axion experiment. Axions are still only purely hypothetical particles. Their detection could solve two fundamental problems in particle physics: What dark matter consists of and why it has not yet been possible to directly observe a CP violation for the strong interaction.

The “MADMAX” project is the MPP’s commitment to axion research. Axions are so far only a theoretical prediction and are difficult to detect: on the one hand,...

Im Focus: Molecules change shape when wet

Broadband rotational spectroscopy unravels structural reshaping of isolated molecules in the gas phase to accommodate water

In two recent publications in the Journal of Chemical Physics and in the Journal of Physical Chemistry Letters, researchers around Melanie Schnell from the Max...

Im Focus: Fraunhofer ISE Develops Highly Compact, High Frequency DC/DC Converter for Aviation

The efficiency of power electronic systems is not solely dependent on electrical efficiency but also on weight, for example, in mobile systems. When the weight of relevant components and devices in airplanes, for instance, is reduced, fuel savings can be achieved and correspondingly greenhouse gas emissions decreased. New materials and components based on gallium nitride (GaN) can help to reduce weight and increase the efficiency. With these new materials, power electronic switches can be operated at higher switching frequency, resulting in higher power density and lower material costs.

Researchers at the Fraunhofer Institute for Solar Energy Systems ISE together with partners have investigated how these materials can be used to make power...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

ICTM Conference 2017: Production technology for turbomachine manufacturing of the future

16.11.2016 | Event News

Innovation Day Laser Technology – Laser Additive Manufacturing

01.11.2016 | Event News

#IC2S2: When Social Science meets Computer Science - GESIS will host the IC2S2 conference 2017

14.10.2016 | Event News

 
Latest News

UTSA study describes new minimally invasive device to treat cancer and other illnesses

02.12.2016 | Medical Engineering

Plasma-zapping process could yield trans fat-free soybean oil product

02.12.2016 | Agricultural and Forestry Science

What do Netflix, Google and planetary systems have in common?

02.12.2016 | Physics and Astronomy

VideoLinks
B2B-VideoLinks
More VideoLinks >>>