Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

First French bulldog with sex reversal identified in Spain

24.03.2011
Tana, a female French bulldog, was brought to a veterinary centre for her first vaccination. Specialists there were alerted by the size of her clitoris, which was "larger than normal", and they started to carry out tests. These revealed the first ever genetic alteration ever detected in the reproductive system of this breed – the female puppy had cryptorchid testicles (outside the scrotum).

Genetic alteration of the reproductive system or sexual reversal "has been described in many species, such as goats, pigs, horses and even human beings", Marcos Campos, lead author of the study and also a researcher at the CEU-Cardenal Herrera University and director of the Reprovalcan assisted reproduction centre for small animals, tells SINC.

The puppy Tana, which was three months old when brought for her first consultation, presented symptoms compatible with having a genetic alteration of the reproductive system – she had a large clitoris. "She was a chromosomally XX female but with masculine gonads (cryptorchid testicles) due to the presence of other genes that determined the formation of testicles in the absence of the genes present on the Y chromosome", explains Campos.

This alteration, which has also been described in another 18 breeds of dog around the world, is "uncommon but it can occur". Sex reversal causes sterility and, over the long term, may predispose the animal to pathologies such as infections or tumours of the gonads, "since this is not a normal genital", the veterinarian explains.

The study, which has been published in Reproduction in Domestic Animals, showed that the urethra ended in the bladder, and the clitoris, which was 0.8 centimetres long, contained a penis bone, which predisposed it to urinary infections that would likely cause the dog to be infertile.

Canine hermaphroditism with a happy ending

The puppy, which is the first documented case anywhere in the world of a French bulldog with this alteration, had a low level of masculinisation, since despite the size of the clitoris, the vulva was normal.

To prevent Tana from suffering any medical complications, the best option was felt to be surgical sterilisation, during which her genitals were completely removed and later sent to a histopathology laboratory. "The puppy is now in perfect health", says Campos.

The veterinarians suggest that the parents of hermaphrodite puppies should be withdrawn from breeding programmes, because "it is likely that at least half of their litters will be carriers". The siblings of affected puppies should not be allowed to breed either until the mutant genes have been identified, which would make it possible to eliminate the carriers.

However, there are still no data available about the affected dogs belonging to this particular breed, which would enable the heredity model to be identified. Genetic modelling from other breeds shows that this is a autosomal recessive alteration (the animal only needs to receive the abnormal gene from one of its parents in order to inherit the sex reversal).

References:

Campos, M.; Moreno-Manzano, V.; García-Roselló, M.; García-Roselló, E. "SRY-Negative XX Sex Reversal in a French Bulldog" Reproduction in Domestic Animals 46(1): 185-188, February 2011

SINC | EurekAlert!
Further information:
http://www.plataformasinc.es

More articles from Life Sciences:

nachricht Closing in on advanced prostate cancer
13.12.2017 | Institute for Research in Biomedicine (IRB Barcelona)

nachricht Visualizing single molecules in whole cells with a new spin
13.12.2017 | Wyss Institute for Biologically Inspired Engineering at Harvard

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Long-lived storage of a photonic qubit for worldwide teleportation

MPQ scientists achieve long storage times for photonic quantum bits which break the lower bound for direct teleportation in a global quantum network.

Concerning the development of quantum memories for the realization of global quantum networks, scientists of the Quantum Dynamics Division led by Professor...

Im Focus: Electromagnetic water cloak eliminates drag and wake

Detailed calculations show water cloaks are feasible with today's technology

Researchers have developed a water cloaking concept based on electromagnetic forces that could eliminate an object's wake, greatly reducing its drag while...

Im Focus: Scientists channel graphene to understand filtration and ion transport into cells

Tiny pores at a cell's entryway act as miniature bouncers, letting in some electrically charged atoms--ions--but blocking others. Operating as exquisitely sensitive filters, these "ion channels" play a critical role in biological functions such as muscle contraction and the firing of brain cells.

To rapidly transport the right ions through the cell membrane, the tiny channels rely on a complex interplay between the ions and surrounding molecules,...

Im Focus: Towards data storage at the single molecule level

The miniaturization of the current technology of storage media is hindered by fundamental limits of quantum mechanics. A new approach consists in using so-called spin-crossover molecules as the smallest possible storage unit. Similar to normal hard drives, these special molecules can save information via their magnetic state. A research team from Kiel University has now managed to successfully place a new class of spin-crossover molecules onto a surface and to improve the molecule’s storage capacity. The storage density of conventional hard drives could therefore theoretically be increased by more than one hundred fold. The study has been published in the scientific journal Nano Letters.

Over the past few years, the building blocks of storage media have gotten ever smaller. But further miniaturization of the current technology is hindered by...

Im Focus: Successful Mechanical Testing of Nanowires

With innovative experiments, researchers at the Helmholtz-Zentrums Geesthacht and the Technical University Hamburg unravel why tiny metallic structures are extremely strong

Light-weight and simultaneously strong – porous metallic nanomaterials promise interesting applications as, for instance, for future aeroplanes with enhanced...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

See, understand and experience the work of the future

11.12.2017 | Event News

Innovative strategies to tackle parasitic worms

08.12.2017 | Event News

AKL’18: The opportunities and challenges of digitalization in the laser industry

07.12.2017 | Event News

 
Latest News

A whole-body approach to understanding chemosensory cells

13.12.2017 | Health and Medicine

Water without windows: Capturing water vapor inside an electron microscope

13.12.2017 | Physics and Astronomy

Cellular Self-Digestion Process Triggers Autoimmune Disease

13.12.2017 | Life Sciences

VideoLinks
B2B-VideoLinks
More VideoLinks >>>