Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Freeze! A protein group affecting lipid dynamics at cell membranes discovered

23.09.2013
Eukaryotic cells are compartmentalized by membranes, whose shape and dynamics are precisely regulated to maintain their correct functions. Consequently, many cellular processes such as endocytosis, migration and morphogenesis rely on proteins that bind directly to membranes and sculpt them into desired shapes.

BAR domain proteins are among the central membrane-sculpting proteins in all eukaryote cells. Studies by Pekka Lappalainen laboratory at Institute of Biotechnology, University of Helsinki, Finland, now reveal that BAR domain proteins not only bend membranes, but also generate extremely stable lipid microdomains by inhibiting the lateral diffusion of certain lipids nearly completely.


BAR proteins can create stable lipid microdomains at cell membranes.

Credit: Hongxia Zhao

In a new study published in Cell Reports, Hongxia Zhao working in the Lappalainen laboratory discovered that all BAR domain proteins induce strong clustering of phosphoinositides, which are important lipids involved in regulating protein functions and cellular signalling.

Her studies also revealed that BAR domains assemble into extremely stable scaffolds on the membrane. Surprisingly, mobility of phosphoinositides was nearly completely frozen in these BAR domain induced lipid platforms. These extremely stable protein-lipid scaffolds may contribute to diverse cellular processes by generating lipid phase boundaries at the tips of the BAR domain scaffolds.

Furthermore, the membrane microdomains induced by BAR domains are expected to function as diffusion barriers, which may for example trap membrane-associated receptor and cargo molecules at the endocytic bud.

Thus, distribution and mobility of specific lipid species at the plasma membrane appears to precisely regulated by membrane-associated proteins. Hongxia Zhao is now continuing studies on regulation of lipid dynamics as an Academy Research Fellow at University of Helsinki.

Pekka Lappalainen | EurekAlert!
Further information:
http://www.helsinki.fi

More articles from Life Sciences:

nachricht Water forms 'spine of hydration' around DNA, group finds
26.05.2017 | Cornell University

nachricht How herpesviruses win the footrace against the immune system
26.05.2017 | Helmholtz-Zentrum für Infektionsforschung

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Can the immune system be boosted against Staphylococcus aureus by delivery of messenger RNA?

Staphylococcus aureus is a feared pathogen (MRSA, multi-resistant S. aureus) due to frequent resistances against many antibiotics, especially in hospital infections. Researchers at the Paul-Ehrlich-Institut have identified immunological processes that prevent a successful immune response directed against the pathogenic agent. The delivery of bacterial proteins with RNA adjuvant or messenger RNA (mRNA) into immune cells allows the re-direction of the immune response towards an active defense against S. aureus. This could be of significant importance for the development of an effective vaccine. PLOS Pathogens has published these research results online on 25 May 2017.

Staphylococcus aureus (S. aureus) is a bacterium that colonizes by far more than half of the skin and the mucosa of adults, usually without causing infections....

Im Focus: A quantum walk of photons

Physicists from the University of Würzburg are capable of generating identical looking single light particles at the push of a button. Two new studies now demonstrate the potential this method holds.

The quantum computer has fuelled the imagination of scientists for decades: It is based on fundamentally different phenomena than a conventional computer....

Im Focus: Turmoil in sluggish electrons’ existence

An international team of physicists has monitored the scattering behaviour of electrons in a non-conducting material in real-time. Their insights could be beneficial for radiotherapy.

We can refer to electrons in non-conducting materials as ‘sluggish’. Typically, they remain fixed in a location, deep inside an atomic composite. It is hence...

Im Focus: Wafer-thin Magnetic Materials Developed for Future Quantum Technologies

Two-dimensional magnetic structures are regarded as a promising material for new types of data storage, since the magnetic properties of individual molecular building blocks can be investigated and modified. For the first time, researchers have now produced a wafer-thin ferrimagnet, in which molecules with different magnetic centers arrange themselves on a gold surface to form a checkerboard pattern. Scientists at the Swiss Nanoscience Institute at the University of Basel and the Paul Scherrer Institute published their findings in the journal Nature Communications.

Ferrimagnets are composed of two centers which are magnetized at different strengths and point in opposing directions. Two-dimensional, quasi-flat ferrimagnets...

Im Focus: World's thinnest hologram paves path to new 3-D world

Nano-hologram paves way for integration of 3-D holography into everyday electronics

An Australian-Chinese research team has created the world's thinnest hologram, paving the way towards the integration of 3D holography into everyday...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

Marine Conservation: IASS Contributes to UN Ocean Conference in New York on 5-9 June

24.05.2017 | Event News

AWK Aachen Machine Tool Colloquium 2017: Internet of Production for Agile Enterprises

23.05.2017 | Event News

Dortmund MST Conference presents Individualized Healthcare Solutions with micro and nanotechnology

22.05.2017 | Event News

 
Latest News

How herpesviruses win the footrace against the immune system

26.05.2017 | Life Sciences

Water forms 'spine of hydration' around DNA, group finds

26.05.2017 | Life Sciences

First Juno science results supported by University of Leicester's Jupiter 'forecast'

26.05.2017 | Physics and Astronomy

VideoLinks
B2B-VideoLinks
More VideoLinks >>>