Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

For cancer patients, sugar-coated cells are deadly

02.07.2014

Every living cell's surface has a protein-embedded membrane that's covered in polysaccharide chains – a literal sugar coating.

A new study by a Cornell University researcher found this coating is especially thick and pronounced on cancer cells and is a crucial determinant of the cell's survival.

Consisting of long, sugar-decorated molecules called glycoproteins, the coating causes physical changes in the cell membrane that make the cell better able to thrive – leading to a more lethal cancer.

Matthew Paszek, assistant professor of chemical and biomolecular engineering at Cornell and Valerie Weaver, at the University of California, San Francisco, led the study on glycoprotein-induced cancer cell survival, published online in Nature.

The researchers found that long glycoprotein chains on a cancer cell's surface cause the cell membrane to push away from its environment and bend inward. This physical change causes adhesion receptors on the cell surface called integrins to clump together. Integrins bind to protein scaffolds in their environment and regulate pretty much everything a cell does – movement, change and growth.

This clustering mechanism causes the integrins to alter the cell's normal signaling, leading to unchecked growth and survival.

"Changes to the sugar composition on the cell surface could alter physically how receptors are organized," he said. "That's really the big thing: coupling the regulation of the sugar coating to these biochemical signaling molecules."

The paper, "The cancer glycocalyx mechanically primes integrin-mediated growth and survival," was the subject of a "News and Views" feature in Nature.

Melissa Osgood | Eurek Alert!

Further reports about: Nature Weaver biochemical coating deadly found glycoproteins lethal mechanism movement regulate sugar

More articles from Life Sciences:

nachricht Rice University lab runs crowd-sourced competition to create 'big data' diagnostic tools
30.06.2016 | Rice University

nachricht A protein coat helps chromosomes keep their distance
30.06.2016 | IMBA - Institut für Molekulare Biotechnologie der Österreichischen Akademie der Wissenschaften GmbH

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Thousands on one chip: New Method to study Proteins

Since the completion of the human genome an important goal has been to elucidate the function of the now known proteins: a new molecular method enables the investigation of the function for thousands of proteins in parallel. Applying this new method, an international team of researchers with leading participation of the Technical University of Munich (TUM) was able to identify hundreds of previously unknown interactions among proteins.

The human genome and those of most common crops have been decoded for many years. Soon it will be possible to sequence your personal genome for less than 1000...

Im Focus: Optical lenses, hardly larger than a human hair

3D printing enables the smalles complex micro-objectives

3D printing revolutionized the manufacturing of complex shapes in the last few years. Using additive depositing of materials, where individual dots or lines...

Im Focus: Flexible OLED applications arrive

R2D2, a joint project to analyze and development high-TRL processes and technologies for manufacture of flexible organic light-emitting diodes (OLEDs) funded by the German Federal Ministry of Education and Research (BMBF) has been successfully completed.

In contrast to point light sources like LEDs made of inorganic semiconductor crystals, organic light-emitting diodes (OLEDs) are light-emitting surfaces. Their...

Im Focus: Unexpected flexibility found in odorant molecules

High resolution rotational spectroscopy reveals an unprecedented number of conformations of an odorant molecule – a new world record!

In a recent publication in the journal Physical Chemistry Chemical Physics, researchers from the Max Planck Institute for the Structure and Dynamics of Matter...

Im Focus: 3-D printing produces cartilage from strands of bioink

Strands of cow cartilage substitute for ink in a 3D bioprinting process that may one day create cartilage patches for worn out joints, according to a team of engineers. "Our goal is to create tissue that can be used to replace large amounts of worn out tissue or design patches," said Ibrahim T. Ozbolat, associate professor of engineering science and mechanics. "Those who have osteoarthritis in their joints suffer a lot. We need a new alternative treatment for this."

Cartilage is a good tissue to target for scale-up bioprinting because it is made up of only one cell type and has no blood vessels within the tissue. It is...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

Quantum technologies to revolutionise 21st century - Nobel Laureates discuss at Lindau

30.06.2016 | Event News

International Conference ‘GEO BON’ Wants to Close Knowledge Gaps in Global Biodiversity

28.06.2016 | Event News

ERES 2016: The largest conference in the European real estate industry

09.06.2016 | Event News

 
Latest News

Modeling NAFLD with human pluripotent stem cell derived immature hepatocyte like cells

30.06.2016 | Health and Medicine

Rice University lab runs crowd-sourced competition to create 'big data' diagnostic tools

30.06.2016 | Life Sciences

A drop of water as a model for the interplay of adhesion and stiction

30.06.2016 | Physics and Astronomy

VideoLinks
B2B-VideoLinks
More VideoLinks >>>