Contrary to popular belief, the foodborne pathogen Campylobacter jejuni is not a harmless commensal in chickens but can cause disease in some breeds of poultry according to research published in mBio®, the online open-access journal of the American Society for Microbiology.
"The main implication is that Campylobacter is not always harmless to chickens. This rather changes our view of the biology of this nasty little bug," says Paul Wigley of Institute for Infection and Global Health at the University of Liverpool, an author on the study.
Campylobacter jejuni is the most frequent cause of foodborne bacterial gastroenteritis in the world and the Centers for Disease Control and Prevention estimate it affects approximately 1.3 million people per year in the United States. Chicken is the most common source of infections.
Infection of chickens had previously not been considered to cause disease and the bacteria were thought to be part of the normal microbiota of the birds.
In the study, Wigley and his colleagues experimentally infected birds from four commercial breeds of broiler chickens. They found that while levels of the bacteria in the intestines did not differ by breed, immune response and inflammation did, to the extent that one breed showed damage to the gut mucosa and developed diarrhea.
"Interestingly the breeds did not differ in the levels of bacteria we found in their intestines after infection, even when kept to normal slaughter age," says Wigley. "This suggests that chicken breed has little direct effect on the risk of Campylobacter entering the food chain but has a big effect on the health of the birds."
The most important finding, says Wigley, is that Campylobacter infection directly impacts broiler chicken health and welfare. The United States produces over 8 billion broiler chickens per year and the United Kingdom produces nearly a billion. As Campylobacter is common, or even endemic, in these industries then the scale of the impact on animal health is clear to see.
"On the positive side, we now know that chickens produce a robust immune response to infection, which in the longer term may allow us to develop vaccines," says Wigley.
The research was funded by the Biotechnology and Biological Sciences Research Council (BBSRC) as well as a consortium of poultry producers, breeders and retailers.
mBio® is an open access online journal published by the American Society for Microbiology to make microbiology research broadly accessible. The focus of the journal is on rapid publication of cutting-edge research spanning the entire spectrum of microbiology and related fields. It can be found online at http://mbio.asm.org.
The American Society for Microbiology is the largest single life science society, composed of over 39,000 scientists and health professionals. ASM's mission is to advance the microbiological sciences as a vehicle for understanding life processes and to apply and communicate this knowledge for the improvement of health and environmental and economic well-being worldwide.
Jim Sliwa | Eurek Alert!
Fruit fly studies shed light on adaptability of nerve cells
17.04.2015 | Deutsches Zentrum für Neurodegenerative Erkrankungen e.V. (DZNE)
Rare monkey photographed in Congo's newest national park, Ntokou-Pikounda
17.04.2015 | Wildlife Conservation Society
Astronomers from Chalmers University of Technology have used the giant telescope Alma to reveal an extremely powerful magnetic field very close to a supermassive black hole in a distant galaxy
Astronomers from Chalmers University of Technology have used the giant telescope Alma to reveal an extremely powerful magnetic field very close to a...
A team of physicists from MPQ, Caltech, and ICFO proposes the combination of nano-photonics with ultracold atoms for simulating quantum many-body systems and creating new states of matter.
Ultracold atoms in the so-called optical lattices, that are generated by crosswise superposition of laser beams, have been proven to be one of the most...
According to new research out of the Texas A&M Health Science Center College of Medicine, that is indeed the case. Chetan Jinadatha, M.D., M.P.H., assistant...
Researchers from ICFO, MIT and UC Riverside have been able to develop a graphene-based photodetector capable of converting absorbed light into an electrical voltage at ultrafast timescales
The efficient conversion of light into electricity plays a crucial role in many technologies, ranging from cameras to solar cells.
Electrical charges not only move through wires, they also travel along lengths of DNA, the molecule of life. The property is known as charge transport.
In a new study appearing in the journal Nature Chemistry, authors, Limin Xiang, Julio Palma, Christopher Bruot and others at Arizona State University's...
13.04.2015 | Event News
25.03.2015 | Event News
19.03.2015 | Event News
17.04.2015 | Power and Electrical Engineering
17.04.2015 | Earth Sciences
17.04.2015 | Physics and Astronomy