Contrary to popular belief, the foodborne pathogen Campylobacter jejuni is not a harmless commensal in chickens but can cause disease in some breeds of poultry according to research published in mBio®, the online open-access journal of the American Society for Microbiology.
"The main implication is that Campylobacter is not always harmless to chickens. This rather changes our view of the biology of this nasty little bug," says Paul Wigley of Institute for Infection and Global Health at the University of Liverpool, an author on the study.
Campylobacter jejuni is the most frequent cause of foodborne bacterial gastroenteritis in the world and the Centers for Disease Control and Prevention estimate it affects approximately 1.3 million people per year in the United States. Chicken is the most common source of infections.
Infection of chickens had previously not been considered to cause disease and the bacteria were thought to be part of the normal microbiota of the birds.
In the study, Wigley and his colleagues experimentally infected birds from four commercial breeds of broiler chickens. They found that while levels of the bacteria in the intestines did not differ by breed, immune response and inflammation did, to the extent that one breed showed damage to the gut mucosa and developed diarrhea.
"Interestingly the breeds did not differ in the levels of bacteria we found in their intestines after infection, even when kept to normal slaughter age," says Wigley. "This suggests that chicken breed has little direct effect on the risk of Campylobacter entering the food chain but has a big effect on the health of the birds."
The most important finding, says Wigley, is that Campylobacter infection directly impacts broiler chicken health and welfare. The United States produces over 8 billion broiler chickens per year and the United Kingdom produces nearly a billion. As Campylobacter is common, or even endemic, in these industries then the scale of the impact on animal health is clear to see.
"On the positive side, we now know that chickens produce a robust immune response to infection, which in the longer term may allow us to develop vaccines," says Wigley.
The research was funded by the Biotechnology and Biological Sciences Research Council (BBSRC) as well as a consortium of poultry producers, breeders and retailers.
mBio® is an open access online journal published by the American Society for Microbiology to make microbiology research broadly accessible. The focus of the journal is on rapid publication of cutting-edge research spanning the entire spectrum of microbiology and related fields. It can be found online at http://mbio.asm.org.
The American Society for Microbiology is the largest single life science society, composed of over 39,000 scientists and health professionals. ASM's mission is to advance the microbiological sciences as a vehicle for understanding life processes and to apply and communicate this knowledge for the improvement of health and environmental and economic well-being worldwide.
Jim Sliwa | Eurek Alert!
Tracking the American Woodcock
28.07.2015 | University of Arkansas, Fayetteville
Possible Path Toward First Anti-MERS Drugs
28.07.2015 | American Crystallographic Association (ACA)
Researchers have developed an ultrafast light-emitting device that can flip on and off 90 billion times a second and could form the basis of optical computing.
Joint BioEnergy Institute study identifies bacterial protein that is key to protecting rice against bacterial blight
A bacterial signal that when recognized by rice plants enables the plants to resist a devastating blight disease has been identified by a multi-national team...
Researchers in the Cockrell School of Engineering at The University of Texas at Austin are one step closer to delivering smart windows with a new level of energy efficiency, engineering materials that allow windows to reveal light without transferring heat and, conversely, to block light while allowing heat transmission, as described in two new research papers.
By allowing indoor occupants to more precisely control the energy and sunlight passing through a window, the new materials could significantly reduce costs for...
Argonne scientists used Mira to identify and improve a new mechanism for eliminating friction, which fed into the development of a hybrid material that exhibited superlubricity at the macroscale for the first time. Argonne Leadership Computing Facility (ALCF) researchers helped enable the groundbreaking simulations by overcoming a performance bottleneck that doubled the speed of the team's code.
While reviewing the simulation results of a promising new lubricant material, Argonne researcher Sanket Deshmukh stumbled upon a phenomenon that had never been...
A NASA camera on the Deep Space Climate Observatory (DSCOVR) satellite has returned its first view of the entire sunlit side of Earth from one million miles away.
The color images of Earth from NASA's Earth Polychromatic Imaging Camera (EPIC) are generated by combining three separate images to create a...
23.07.2015 | Event News
10.07.2015 | Event News
25.06.2015 | Event News
28.07.2015 | Life Sciences
28.07.2015 | Materials Sciences
28.07.2015 | Ecology, The Environment and Conservation