Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Finding the needle in the proteomic haystack

18.06.2010
Researchers at the RIKEN have demonstrated that a technique for tagging and profiling proteins can be used to accurately classify anti-cancer drugs based on the molecules they target. The technique promises to accelerate the process of proteomic profiling and contribute to more effective drug discovery.

Researchers at the RIKEN Advanced Science Institute have demonstrated that a technique for tagging and profiling proteins can be used to accurately classify anti-cancer drugs based on the molecules they target. The technique, developed in collaboration with a researcher at the University of Tsukuba, promises to accelerate the process of proteomic profiling and contribute to more effective drug discovery.

While essential for effective treatment, our understanding of the complex relationship between drugs and their molecular targets is far from complete. Drug efficacy is thus low, and drugs are often accompanied by dangerous side effects. Targeted cancer therapies, which act by interfering with specific molecules contributing to tumor growth, can bring therapeutic benefits to certain patients, yet are not free of these problems. Solving them depends on connecting drugs to their molecular targets, a task complicated by the huge variety of proteins and complexity of drug-target networks.

In recent years, the field of proteomics has produced powerful techniques that simplify this task by accurately identifying proteins and their interactions. The research team used one of these techniques, two-dimensional difference gel electrophoresis (2D-DIGE), to analyze and compare changes of protein expression levels in HeLa cancer cells treated with 19 well-known anti-cancer agents. The method successfully classified compounds of different structures but sharing molecular target(s), while revealing that compounds previously reported to inhibit the same process in fact were clustered into different groups, highlighting differences in underlying interaction mechanisms.

Described in the journal Chemistry and Biology, the findings broaden the scope of proteomic profiling by enabling researchers to characterize specific compounds in terms of how they interact with biomolecules. While refining the drug discovery process, this advance also contributes to minimizing side-effects, potentially supporting the future development of safer and more effective anticancer drugs.

For more information, please contact:

Dr. Hiroyuki Osada
Dr. Makoto Muroi
Chemical Library Validation Team
RIKEN Advanced Science Institute (ASI)
Tel: +81-(0)48-467-4839 / Fax: +81-(0)48-462-4669
Ms. Tomoko Ikawa (PI officer)
Global Relations Office
RIKEN
Tel: +81-(0)48-462-1225 / Fax: +81-(0)48-462-4715
Email: koho@riken.jp

gro-pr | Research asia research news
Further information:
http://www.riken.jp
http://www.researchsea.com

More articles from Life Sciences:

nachricht What happens in the cell nucleus after fertilization
06.12.2016 | Helmholtz Zentrum München - Deutsches Forschungszentrum für Gesundheit und Umwelt

nachricht Researchers uncover protein-based “cancer signature”
05.12.2016 | Universität Basel

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Significantly more productivity in USP lasers

In recent years, lasers with ultrashort pulses (USP) down to the femtosecond range have become established on an industrial scale. They could advance some applications with the much-lauded “cold ablation” – if that meant they would then achieve more throughput. A new generation of process engineering that will address this issue in particular will be discussed at the “4th UKP Workshop – Ultrafast Laser Technology” in April 2017.

Even back in the 1990s, scientists were comparing materials processing with nanosecond, picosecond and femtosesecond pulses. The result was surprising:...

Im Focus: Shape matters when light meets atom

Mapping the interaction of a single atom with a single photon may inform design of quantum devices

Have you ever wondered how you see the world? Vision is about photons of light, which are packets of energy, interacting with the atoms or molecules in what...

Im Focus: Novel silicon etching technique crafts 3-D gradient refractive index micro-optics

A multi-institutional research collaboration has created a novel approach for fabricating three-dimensional micro-optics through the shape-defined formation of porous silicon (PSi), with broad impacts in integrated optoelectronics, imaging, and photovoltaics.

Working with colleagues at Stanford and The Dow Chemical Company, researchers at the University of Illinois at Urbana-Champaign fabricated 3-D birefringent...

Im Focus: Quantum Particles Form Droplets

In experiments with magnetic atoms conducted at extremely low temperatures, scientists have demonstrated a unique phase of matter: The atoms form a new type of quantum liquid or quantum droplet state. These so called quantum droplets may preserve their form in absence of external confinement because of quantum effects. The joint team of experimental physicists from Innsbruck and theoretical physicists from Hannover report on their findings in the journal Physical Review X.

“Our Quantum droplets are in the gas phase but they still drop like a rock,” explains experimental physicist Francesca Ferlaino when talking about the...

Im Focus: MADMAX: Max Planck Institute for Physics takes up axion research

The Max Planck Institute for Physics (MPP) is opening up a new research field. A workshop from November 21 - 22, 2016 will mark the start of activities for an innovative axion experiment. Axions are still only purely hypothetical particles. Their detection could solve two fundamental problems in particle physics: What dark matter consists of and why it has not yet been possible to directly observe a CP violation for the strong interaction.

The “MADMAX” project is the MPP’s commitment to axion research. Axions are so far only a theoretical prediction and are difficult to detect: on the one hand,...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

ICTM Conference 2017: Production technology for turbomachine manufacturing of the future

16.11.2016 | Event News

Innovation Day Laser Technology – Laser Additive Manufacturing

01.11.2016 | Event News

#IC2S2: When Social Science meets Computer Science - GESIS will host the IC2S2 conference 2017

14.10.2016 | Event News

 
Latest News

Simple processing technique could cut cost of organic PV and wearable electronics

06.12.2016 | Materials Sciences

3-D printed kidney phantoms aid nuclear medicine dosing calibration

06.12.2016 | Medical Engineering

Robot on demand: Mobile machining of aircraft components with high precision

06.12.2016 | Power and Electrical Engineering

VideoLinks
B2B-VideoLinks
More VideoLinks >>>