Experiments show that calcium, when bound to a protein called calmodulin, prompts plants to make salicylic acid (SA) when threatened by infection or other danger. SA is a close chemical relative of aspirin. In plants, SA acts as a signal molecule that kicks off a series of reactions that help defend against external threats.
That plants make salicylic acid has been known for more than 100 years, said B.W. Poovaiah, Regents Professor and director of the study, but the role of calcium in signaling a plant to make SA has not been known before.
“We are now beginning to understand the molecular mechanism connecting the calcium/calmodulin signaling to plant immunity,” said Poovaiah.
The study will appear in an upcoming issue of the journal Nature and is now available online at http://dx.doi.org/10.1038/nature07612.
Poovaiah said that in controlling salicylic acid level, calcium acts like a gatekeeper within the cells of a plant, directing incoming information and helping the plant respond to such dangers as pathogen attacks. Normal, healthy plants have a low level of SA in their cells. That level rises when the plant is threatened by infection or environmental stress.
“When we expect danger, we try to take precautions,” said Poovaiah. “Plants cannot run away. Plants have to turn on their built-in system to protect themselves. The plant has to produce different signal molecules. One of them is salicylic acid.”
According to lead author, assistant research professor Liqun Du, SA sets off defensive measures within the plant, such as the “hypersensitive reaction” in which cells around an infection site die, forming a barrier that keeps the pathogen from invading deeper into the plant. That provides protection against the immediate threat. SA also activates the plant’s systemic acquired resistance, a form of immunity that protects the plant from further pathogen attacks.
But a rise in SA levels also causes the plant to slow its growth, perhaps saving its strength for the battle against the pathogen. That sets up a challenging situation for both the plant—grow faster or protect myself better?—and farmers, who might view SA as a tool to protect their plants from disease. A plant that makes high levels of SA all the time will be safe from infection but will grow slowly. A plant that makes little or no SA will grow like gangbusters but be very susceptible to infection.
“It’s a fine balance,” said Du. “Too much is bad; too little is bad.”
Working with the small mustard plant Arabidopsis thaliana, Poovaiah’s research team showed that the key step in this balancing act is the interaction between calcium/calmodulin and a protein called AtSR1, which suppresses the production of salicylic acid. Stress or infection causes a spike in calcium within the plant cells, which, in combination with calmodulin, acts as a specific signal controlling the activity of AtSR1 and the formation of SA.
In an environment with few pathogens, a plant will have low levels of SA. The plant lets its guard down and devotes more resources to growth. If it becomes infected, SA production goes up, and the plant dials back its growth and puts more resources into defense.
The importance of AtSR1 was especially clear in experiments in which plants were engineered to have more or less AtSR1 than normal. Plants that have extra AtSR1 make almost no SA. They grow larger and faster than a normal plant, but easily succumb to infection. Plants that lack the gene for AtSR1 develop high levels of SA and deploy their immune responses all the time. They are nearly impervious to infection, but small in size. The same is true of plants whose AtSR1 has been changed so it cannot bind to calcium/calmodulin, demonstrating the crucial role played in this system by calcium and calmodulin.
The paper is titled “Calcium/Calmodulin Regulates Salicylic Acid-mediated Immune Response in Plants through AtSR1/CAMTA3.”
Joe Poovaiah | Newswise Science News
Decoding the genome's cryptic language
27.02.2017 | University of California - San Diego
New risk factors for anxiety disorders
24.02.2017 | Julius-Maximilians-Universität Würzburg
On January 15, 2009, Chesley B. Sullenberger was celebrated world-wide: after the two engines had failed due to bird strike, he and his flight crew succeeded after a glide flight with an Airbus A320 in ditching on the Hudson River. All 155 people on board were saved.
On January 15, 2009, Chesley B. Sullenberger was celebrated world-wide: after the two engines had failed due to bird strike, he and his flight crew succeeded...
In the field of nanoscience, an international team of physicists with participants from Konstanz has achieved a breakthrough in understanding heat transport
Cells need to repair damaged DNA in our genes to prevent the development of cancer and other diseases. Our cells therefore activate and send “repair-proteins”...
The Fraunhofer IWS Dresden and Technische Universität Dresden inaugurated their jointly operated Center for Additive Manufacturing Dresden (AMCD) with a festive ceremony on February 7, 2017. Scientists from various disciplines perform research on materials, additive manufacturing processes and innovative technologies, which build up components in a layer by layer process. This technology opens up new horizons for component design and combinations of functions. For example during fabrication, electrical conductors and sensors are already able to be additively manufactured into components. They provide information about stress conditions of a product during operation.
The 3D-printing technology, or additive manufacturing as it is often called, has long made the step out of scientific research laboratories into industrial...
Nature does amazing things with limited design materials. Grass, for example, can support its own weight, resist strong wind loads, and recover after being...
13.02.2017 | Event News
10.02.2017 | Event News
09.02.2017 | Event News
27.02.2017 | Materials Sciences
27.02.2017 | Interdisciplinary Research
27.02.2017 | Life Sciences