Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Feinstein Institute researcher discovers new protein regulator of taste

07.03.2013
In collaboration with other research institutions, a Feinstein Institute for Medical Research investigator discovered a new protein that controls the sense of taste. The findings are published in the March issue of Nature.

In a search for new proteins involved in the progression of Alzheimer's disease, Philippe Marambaud, PhD, an investigator in the Litwin-Zucker Research Center for the Study of Alzheimer's Disease at the Feinstein Institute, discovered the protein calcium homeostasis modulator 1 (CALHM1) in 2008. CALHM1 represents a new family of pore-forming membrane proteins involved in the control of the levels of amyloid-beta peptide, a main trigger for Alzheimer's disease.

After additional studies in a mouse that did not have the CALHM1 gene, Dr. Marambaud and his lab found that the mouse had severely impaired perceptions of sweet, bitter and umami (a savory taste that is abundant in fish, shellfish, cured meats, mushrooms, and vegetables) tastes. This indicated that CALHM1 is of paramount importance for the integrity of the sense of taste.

"While studying the role of CALHM1 in the context of Alzheimer's disease, we realized that this protein also plays a fundamental role in normal physiology, that is taste perception," said Dr. Marambaud. "This finding is exciting because it unravels the mechanism of communication to the brain during taste perception. The connection between Alzheimer's disease and taste is unclear at this point, but this study might motivate some investigation in this field."

About the Litwin-Zucker Research Center for the Study of Alzheimer's Disease

The Litwin-Zucker Research Center is part of the Feinstein Institute for Medical Research. Researchers who work in the lab have been studying Alzheimer's disease in an effort of identifying new treatments and diagnostics for this devastating disorder of the brain.

About The Feinstein Institute for Medical Research

Headquartered in Manhasset, NY, The Feinstein Institute for Medical Research is home to international scientific leaders in many areas including Parkinson's disease, Alzheimer's disease, psychiatric disorders, rheumatoid arthritis, lupus, sepsis, human genetics, pulmonary hypertension, leukemia, neuroimmunology, and medicinal chemistry. The Feinstein Institute, part of the North Shore-LIJ Health System, ranks in the top 5th percentile of all National Institutes of Health grants awarded to research centers. For more information visit www.FeinsteinInstitute.org.

Emily Ng | EurekAlert!
Further information:
http://www.nshs.edu
http://www.FeinsteinInstitute.org

More articles from Life Sciences:

nachricht Desert ants cannot be fooled
23.11.2017 | Max-Planck-Institut für chemische Ökologie

nachricht Bacteria as pacemaker for the intestine
22.11.2017 | Christian-Albrechts-Universität zu Kiel

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Frictional Heat Powers Hydrothermal Activity on Enceladus

Computer simulation shows how the icy moon heats water in a porous rock core

Heat from the friction of rocks caused by tidal forces could be the “engine” for the hydrothermal activity on Saturn's moon Enceladus. This presupposes that...

Im Focus: Nanoparticles help with malaria diagnosis – new rapid test in development

The WHO reports an estimated 429,000 malaria deaths each year. The disease mostly affects tropical and subtropical regions and in particular the African continent. The Fraunhofer Institute for Silicate Research ISC teamed up with the Fraunhofer Institute for Molecular Biology and Applied Ecology IME and the Institute of Tropical Medicine at the University of Tübingen for a new test method to detect malaria parasites in blood. The idea of the research project “NanoFRET” is to develop a highly sensitive and reliable rapid diagnostic test so that patient treatment can begin as early as possible.

Malaria is caused by parasites transmitted by mosquito bite. The most dangerous form of malaria is malaria tropica. Left untreated, it is fatal in most cases....

Im Focus: A “cosmic snake” reveals the structure of remote galaxies

The formation of stars in distant galaxies is still largely unexplored. For the first time, astron-omers at the University of Geneva have now been able to closely observe a star system six billion light-years away. In doing so, they are confirming earlier simulations made by the University of Zurich. One special effect is made possible by the multiple reflections of images that run through the cosmos like a snake.

Today, astronomers have a pretty accurate idea of how stars were formed in the recent cosmic past. But do these laws also apply to older galaxies? For around a...

Im Focus: Visual intelligence is not the same as IQ

Just because someone is smart and well-motivated doesn't mean he or she can learn the visual skills needed to excel at tasks like matching fingerprints, interpreting medical X-rays, keeping track of aircraft on radar displays or forensic face matching.

That is the implication of a new study which shows for the first time that there is a broad range of differences in people's visual ability and that these...

Im Focus: Novel Nano-CT device creates high-resolution 3D-X-rays of tiny velvet worm legs

Computer Tomography (CT) is a standard procedure in hospitals, but so far, the technology has not been suitable for imaging extremely small objects. In PNAS, a team from the Technical University of Munich (TUM) describes a Nano-CT device that creates three-dimensional x-ray images at resolutions up to 100 nanometers. The first test application: Together with colleagues from the University of Kassel and Helmholtz-Zentrum Geesthacht the researchers analyzed the locomotory system of a velvet worm.

During a CT analysis, the object under investigation is x-rayed and a detector measures the respective amount of radiation absorbed from various angles....

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

Ecology Across Borders: International conference brings together 1,500 ecologists

15.11.2017 | Event News

Road into laboratory: Users discuss biaxial fatigue-testing for car and truck wheel

15.11.2017 | Event News

#Berlin5GWeek: The right network for Industry 4.0

30.10.2017 | Event News

 
Latest News

Desert ants cannot be fooled

23.11.2017 | Life Sciences

By saving cost and energy, the lighting revolution may increase light pollution

23.11.2017 | Earth Sciences

Retreating permafrost coasts threaten the fragile Arctic environment

23.11.2017 | Earth Sciences

VideoLinks
B2B-VideoLinks
More VideoLinks >>>