Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Fatal blood clot genetic risk breakthrough announcement

25.11.2010
Researchers from Leicester and Cambridge lead discovery of genetic markers that identify people at risk of clot formation and heart attack

An international team led by researchers from the Universities of Leicester and Cambridge has announced a breakthrough in identifying people at risk of developing potentially fatal blood clots that can lead to heart attack.

The discovery, published this week (25 November) in the leading haematology journal Blood, is expected to advance ways of detecting and treating coronary heart disease – the most common form of disease affecting the heart and an important cause of premature death.

The research led by Professor Alison Goodall from the University of Leicester and Professor Willem Ouwehand from the University of Cambridge and NHS Blood and Transplant was carried out in collaboration with colleagues at the Wellcome Trust Sanger Institute, University College Dublin, and the University of Leuven, as part of a large programme to discover novel genes regulating platelets; the tiny cells in the blood that stick together to form a blood clot.

Understanding what makes these cells more sticky in some people than others could provide potential therapeutic targets for treatment of cardiovascular disease.

Lead author Professor Goodall, of the Department of Cardiovascular Sciences at the University of Leicester, said: "We have long known that platelet activity and clot formation varied between different people – but we now have identified some of the genetic reasons for this."

Professor Ouwehand said the research had uncovered a new molecule that plays an important role in platelets. He said: "Studies in large number of NHS patients who experienced a heart attack and healthy controls suggests that genetic differences in the gene for this protein slightly modifies the risk for blood clots. This type of study will help us to unravel the complex question why some people have a higher risk of a heart attack than others. One day this type of research may lead to a new generation of drugs that can be used to reduce the risk of this devastating disease."

The study was carried out as part of the European Union funded Bloodomics's project.

For interviews contact:
Professor Alison H Goodall, PhD
Department of Cardiovascular Sciences
University of Leicester
Tel: +44(0)116 256 3026/3045
email: ahg5@le.ac.uk
The URL to the paper is: http://bloodjournal.hematologylibrary.org/cgi/content/abstract/116/22/4646

This will go live after 2pm EST (7 GMT) on Thursday November 25

Professor Alison H. Goodall | EurekAlert!
Further information:
http://www.le.ac.uk

More articles from Life Sciences:

nachricht Complementing conventional antibiotics
24.05.2018 | Goethe-Universität Frankfurt am Main

nachricht Building a brain, cell by cell: Researchers make a mini neuron network (of two)
23.05.2018 | Institute of Industrial Science, The University of Tokyo

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Molecular switch will facilitate the development of pioneering electro-optical devices

A research team led by physicists at the Technical University of Munich (TUM) has developed molecular nanoswitches that can be toggled between two structurally different states using an applied voltage. They can serve as the basis for a pioneering class of devices that could replace silicon-based components with organic molecules.

The development of new electronic technologies drives the incessant reduction of functional component sizes. In the context of an international collaborative...

Im Focus: LZH showcases laser material processing of tomorrow at the LASYS 2018

At the LASYS 2018, from June 5th to 7th, the Laser Zentrum Hannover e.V. (LZH) will be showcasing processes for the laser material processing of tomorrow in hall 4 at stand 4E75. With blown bomb shells the LZH will present first results of a research project on civil security.

At this year's LASYS, the LZH will exhibit light-based processes such as cutting, welding, ablation and structuring as well as additive manufacturing for...

Im Focus: Self-illuminating pixels for a new display generation

There are videos on the internet that can make one marvel at technology. For example, a smartphone is casually bent around the arm or a thin-film display is rolled in all directions and with almost every diameter. From the user's point of view, this looks fantastic. From a professional point of view, however, the question arises: Is that already possible?

At Display Week 2018, scientists from the Fraunhofer Institute for Applied Polymer Research IAP will be demonstrating today’s technological possibilities and...

Im Focus: Explanation for puzzling quantum oscillations has been found

So-called quantum many-body scars allow quantum systems to stay out of equilibrium much longer, explaining experiment | Study published in Nature Physics

Recently, researchers from Harvard and MIT succeeded in trapping a record 53 atoms and individually controlling their quantum state, realizing what is called a...

Im Focus: Dozens of binaries from Milky Way's globular clusters could be detectable by LISA

Next-generation gravitational wave detector in space will complement LIGO on Earth

The historic first detection of gravitational waves from colliding black holes far outside our galaxy opened a new window to understanding the universe. A...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

VideoLinks
Industry & Economy
Event News

Save the date: Forum European Neuroscience – 07-11 July 2018 in Berlin, Germany

02.05.2018 | Event News

Invitation to the upcoming "Current Topics in Bioinformatics: Big Data in Genomics and Medicine"

13.04.2018 | Event News

Unique scope of UV LED technologies and applications presented in Berlin: ICULTA-2018

12.04.2018 | Event News

 
Latest News

When corals eat plastics

24.05.2018 | Ecology, The Environment and Conservation

Surgery involving ultrasound energy found to treat high blood pressure

24.05.2018 | Medical Engineering

First chip-scale broadband optical system that can sense molecules in the mid-IR

24.05.2018 | Physics and Astronomy

VideoLinks
Science & Research
Overview of more VideoLinks >>>