Adipose-derived stem cells maintain their "stemness" and could be useful for cell-based therapies A team of researchers from several institutions in Italy isolated and characterized adult fat cell-derived stem cells from patients undergoing lipoaspiration (surgical removal of fat deposits) in order to investigate the ability of the fat cells to maintain their stem cell characteristics in in vitro cultures to the point where once transplanted they could aid in tissue regeneration.
According to the study's corresponding authors Dr. Stefami Bucher of the San Gallicano Institute (Rome) and Dr. Rita Falcioni of the Regina Elena Cancer Institute (Rome), adipose tissues share several biological properties with bone marrow, they can be found in abundance, they can be obtained from patients undergoing noninvasive lipoaspirate procedures, and they have the potential to be useful in a range of therapeutic applications.
"The use of lipoaspirate as filling material is a powerful technique for tissue repair in plastic surgery," said Dr. Falcioni. "Increasingly, it is used in oncology to repair tissue damaged by surgical treatments, such as mastectomy. The use of purified adipose-derived stem cells might improve this surgical procedure by shortening the time to achieve esthetic results and thereby improving patient quality of life."
The researchers described adipose tissues as "highly specialized connective tissues" that help provide the body with an energy source, yet little research has investigated the transplant potential of adipose-derived stem cells.
"We strongly suggest that the adipose-derived stem cells we purified in our study could be applied in the near future for cell therapy using the cell-assisted lipotransfer technique."
Contact: Dr. Rita Falcioni, Regina Elena Cancer Institute, Department of Experimental Oncology, Molecular Oncogenesis Laboratory, Via delle Messi d'Oro, 156, 00158 Rome, Italy Tel:+ 39-06- 52662535; Fax: +39-06-52662505 Email: firstname.lastname@example.org
Citation: Folgiero, V.; Migliano, E.; Tedesco, M.; Iacovelli, S.; Bon, G.; Torre, M. L.; Sacchi, A.; Marazzi, M.; Bucher, S.; Falcioni, R. Purification and characterization of adipose-derived stem cells from patients with lipoaspirate transplant. Cell Transplant. 19(10):1225-1235; 2010.
Plastic surgery meets regenerative medicine
"Progenitor, endothelial and mensenchymal stem cells derived from adipose tissues could be central to plastic and reconstructive surgery applications as well as represent the focus for therapies for a number of disease conditions, including those affecting bone, cartilage, muscle, liver, kidney, cardiac, neural and pancreatic tissue," said Dr. Camillo Ricordi, lead author on a paper by researchers from the University of Miami's Cell Transplant Center and Diabetes Research Institute.
According to Dr. Ricordi and colleagues, successful engraftment and long term survival of transplanted adipose tissue has increased interest in structural fat grafting, yet there is a high percentage (up to 70%) of tissue resorption over time. Adipose cells can also fall victim to trauma during harvesting. In contrast, progenitor cells have minimal metabolic requirements and tend to survive longer.
"Adipose-derived stem cells might very well represent the only tissue surviving transplantation," concluded Dr. Ricordi. "There is much more to be learned in tissue remodeling following adipose tissue transplantation and it is time to carefully re-examine the potential implications of autologous fat grafting as being more than the filler concept for which it was originally utilized."
"These two articles highlight the considerable promise for therapeutic and cosmetic benefit from the relatively new derivation of stem cells from fat cells," said Dr. Paul Sanberg, co-editor-in-chief of the journal Cell Transplantation and executive director of the University of South Florida Center of Excellence for Aging and Brain Repair. "It will be of great interest to see how the clinical use of these cells will develop."
Contact: Dr. Camillo Ricordi, Cell Transplant Center and Diabetes Research Institute, University of Miami, 1450 NW 10th Ave., Miami, FL, USA 33136, Tel:+ 305-243-4404; Fax: 305-243-6913 Email: email@example.com
Citation: Tremolada, C.; Palmieri, G.; Ricordi, C. Adipocyte Transplantation and Stem Cells: Plastic Surgery Meets Regenerative Medicine. Cell Transplant. 19(10):1217-1223; 2010.
The editorial offices for Cell Transplantation are at the Center of Excellence for Aging and Brain Repair, College of Medicine, the University of South Florida and the Diabetes Research Institute, University of Miami Miller School of Medicine. Contact, David Eve, PhD. at firstname.lastname@example.org or Camillo Ricordi, MD at email@example.com
News Release by Randolph Fillmore, Florida Science Communications, Inc. www.sciencescribe.net
Oestrogen regulates pathological changes of bones via bone lining cells
28.07.2017 | Veterinärmedizinische Universität Wien
Programming cells with computer-like logic
27.07.2017 | Wyss Institute for Biologically Inspired Engineering at Harvard
Spectrally narrow x-ray pulses may be “sharpened” by purely mechanical means. This sounds surprisingly, but a team of theoretical and experimental physicists developed and realized such a method. It is based on fast motions, precisely synchronized with the pulses, of a target interacting with the x-ray light. Thereby, photons are redistributed within the x-ray pulse to the desired spectral region.
A team of theoretical physicists from the MPI for Nuclear Physics (MPIK) in Heidelberg has developed a novel method to intensify the spectrally broad x-ray...
Physicists working with researcher Oriol Romero-Isart devised a new simple scheme to theoretically generate arbitrarily short and focused electromagnetic fields. This new tool could be used for precise sensing and in microscopy.
Microwaves, heat radiation, light and X-radiation are examples for electromagnetic waves. Many applications require to focus the electromagnetic fields to...
Strong light-matter coupling in these semiconducting tubes may hold the key to electrically pumped lasers
Light-matter quasi-particles can be generated electrically in semiconducting carbon nanotubes. Material scientists and physicists from Heidelberg University...
Fraunhofer IPA has developed a proximity sensor made from silicone and carbon nanotubes (CNT) which detects objects and determines their position. The materials and printing process used mean that the sensor is extremely flexible, economical and can be used for large surfaces. Industry and research partners can use and further develop this innovation straight away.
At first glance, the proximity sensor appears to be nothing special: a thin, elastic layer of silicone onto which black square surfaces are printed, but these...
3-D shape acquisition using water displacement as the shape sensor for the reconstruction of complex objects
A global team of computer scientists and engineers have developed an innovative technique that more completely reconstructs challenging 3D objects. An ancient...
26.07.2017 | Event News
21.07.2017 | Event News
19.07.2017 | Event News
28.07.2017 | Health and Medicine
28.07.2017 | Power and Electrical Engineering
28.07.2017 | Life Sciences