Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Fat cells become useful stem cells in tissue reconstruction

23.12.2010
Two studies appearing in the current issue of Cell Transplantation 19(10) discuss stem cells derived from adipose (fat) cells and their potential use in plastic surgery and tissue reconstruction. The studies are now freely available on-line at http://www.ingentaconnect.com/content/cog/ct/ .

Adipose-derived stem cells maintain their "stemness" and could be useful for cell-based therapies A team of researchers from several institutions in Italy isolated and characterized adult fat cell-derived stem cells from patients undergoing lipoaspiration (surgical removal of fat deposits) in order to investigate the ability of the fat cells to maintain their stem cell characteristics in in vitro cultures to the point where once transplanted they could aid in tissue regeneration.

According to the study's corresponding authors Dr. Stefami Bucher of the San Gallicano Institute (Rome) and Dr. Rita Falcioni of the Regina Elena Cancer Institute (Rome), adipose tissues share several biological properties with bone marrow, they can be found in abundance, they can be obtained from patients undergoing noninvasive lipoaspirate procedures, and they have the potential to be useful in a range of therapeutic applications.

"The use of lipoaspirate as filling material is a powerful technique for tissue repair in plastic surgery," said Dr. Falcioni. "Increasingly, it is used in oncology to repair tissue damaged by surgical treatments, such as mastectomy. The use of purified adipose-derived stem cells might improve this surgical procedure by shortening the time to achieve esthetic results and thereby improving patient quality of life."

The researchers described adipose tissues as "highly specialized connective tissues" that help provide the body with an energy source, yet little research has investigated the transplant potential of adipose-derived stem cells.

"We strongly suggest that the adipose-derived stem cells we purified in our study could be applied in the near future for cell therapy using the cell-assisted lipotransfer technique."

Contact: Dr. Rita Falcioni, Regina Elena Cancer Institute, Department of Experimental Oncology, Molecular Oncogenesis Laboratory, Via delle Messi d'Oro, 156, 00158 Rome, Italy Tel:+ 39-06- 52662535; Fax: +39-06-52662505 Email: falcioni@ifo.it

Citation: Folgiero, V.; Migliano, E.; Tedesco, M.; Iacovelli, S.; Bon, G.; Torre, M. L.; Sacchi, A.; Marazzi, M.; Bucher, S.; Falcioni, R. Purification and characterization of adipose-derived stem cells from patients with lipoaspirate transplant. Cell Transplant. 19(10):1225-1235; 2010.

Plastic surgery meets regenerative medicine

"Progenitor, endothelial and mensenchymal stem cells derived from adipose tissues could be central to plastic and reconstructive surgery applications as well as represent the focus for therapies for a number of disease conditions, including those affecting bone, cartilage, muscle, liver, kidney, cardiac, neural and pancreatic tissue," said Dr. Camillo Ricordi, lead author on a paper by researchers from the University of Miami's Cell Transplant Center and Diabetes Research Institute.

According to Dr. Ricordi and colleagues, successful engraftment and long term survival of transplanted adipose tissue has increased interest in structural fat grafting, yet there is a high percentage (up to 70%) of tissue resorption over time. Adipose cells can also fall victim to trauma during harvesting. In contrast, progenitor cells have minimal metabolic requirements and tend to survive longer.

"Adipose-derived stem cells might very well represent the only tissue surviving transplantation," concluded Dr. Ricordi. "There is much more to be learned in tissue remodeling following adipose tissue transplantation and it is time to carefully re-examine the potential implications of autologous fat grafting as being more than the filler concept for which it was originally utilized."

"These two articles highlight the considerable promise for therapeutic and cosmetic benefit from the relatively new derivation of stem cells from fat cells," said Dr. Paul Sanberg, co-editor-in-chief of the journal Cell Transplantation and executive director of the University of South Florida Center of Excellence for Aging and Brain Repair. "It will be of great interest to see how the clinical use of these cells will develop."

Contact: Dr. Camillo Ricordi, Cell Transplant Center and Diabetes Research Institute, University of Miami, 1450 NW 10th Ave., Miami, FL, USA 33136, Tel:+ 305-243-4404; Fax: 305-243-6913 Email: ricordi@miami.edu

Citation: Tremolada, C.; Palmieri, G.; Ricordi, C. Adipocyte Transplantation and Stem Cells: Plastic Surgery Meets Regenerative Medicine. Cell Transplant. 19(10):1217-1223; 2010.

The editorial offices for Cell Transplantation are at the Center of Excellence for Aging and Brain Repair, College of Medicine, the University of South Florida and the Diabetes Research Institute, University of Miami Miller School of Medicine. Contact, David Eve, PhD. at celltransplantation@gmail.com or Camillo Ricordi, MD at ricordi@miami.edu

News Release by Randolph Fillmore, Florida Science Communications, Inc. www.sciencescribe.net

David Eve | EurekAlert!
Further information:
http://www.miami.edu
http://www.sciencescribe.net

More articles from Life Sciences:

nachricht When Air is in Short Supply - Shedding light on plant stress reactions when oxygen runs short
23.03.2017 | Institut für Pflanzenbiochemie

nachricht WPI team grows heart tissue on spinach leaves
23.03.2017 | Worcester Polytechnic Institute

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Giant Magnetic Fields in the Universe

Astronomers from Bonn and Tautenburg in Thuringia (Germany) used the 100-m radio telescope at Effelsberg to observe several galaxy clusters. At the edges of these large accumulations of dark matter, stellar systems (galaxies), hot gas, and charged particles, they found magnetic fields that are exceptionally ordered over distances of many million light years. This makes them the most extended magnetic fields in the universe known so far.

The results will be published on March 22 in the journal „Astronomy & Astrophysics“.

Galaxy clusters are the largest gravitationally bound structures in the universe. With a typical extent of about 10 million light years, i.e. 100 times the...

Im Focus: Tracing down linear ubiquitination

Researchers at the Goethe University Frankfurt, together with partners from the University of Tübingen in Germany and Queen Mary University as well as Francis Crick Institute from London (UK) have developed a novel technology to decipher the secret ubiquitin code.

Ubiquitin is a small protein that can be linked to other cellular proteins, thereby controlling and modulating their functions. The attachment occurs in many...

Im Focus: Perovskite edges can be tuned for optoelectronic performance

Layered 2D material improves efficiency for solar cells and LEDs

In the eternal search for next generation high-efficiency solar cells and LEDs, scientists at Los Alamos National Laboratory and their partners are creating...

Im Focus: Polymer-coated silicon nanosheets as alternative to graphene: A perfect team for nanoelectronics

Silicon nanosheets are thin, two-dimensional layers with exceptional optoelectronic properties very similar to those of graphene. Albeit, the nanosheets are less stable. Now researchers at the Technical University of Munich (TUM) have, for the first time ever, produced a composite material combining silicon nanosheets and a polymer that is both UV-resistant and easy to process. This brings the scientists a significant step closer to industrial applications like flexible displays and photosensors.

Silicon nanosheets are thin, two-dimensional layers with exceptional optoelectronic properties very similar to those of graphene. Albeit, the nanosheets are...

Im Focus: Researchers Imitate Molecular Crowding in Cells

Enzymes behave differently in a test tube compared with the molecular scrum of a living cell. Chemists from the University of Basel have now been able to simulate these confined natural conditions in artificial vesicles for the first time. As reported in the academic journal Small, the results are offering better insight into the development of nanoreactors and artificial organelles.

Enzymes behave differently in a test tube compared with the molecular scrum of a living cell. Chemists from the University of Basel have now been able to...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

International Land Use Symposium ILUS 2017: Call for Abstracts and Registration open

20.03.2017 | Event News

CONNECT 2017: International congress on connective tissue

14.03.2017 | Event News

ICTM Conference: Turbine Construction between Big Data and Additive Manufacturing

07.03.2017 | Event News

 
Latest News

When Air is in Short Supply - Shedding light on plant stress reactions when oxygen runs short

23.03.2017 | Life Sciences

Researchers use light to remotely control curvature of plastics

23.03.2017 | Power and Electrical Engineering

Sea ice extent sinks to record lows at both poles

23.03.2017 | Earth Sciences

VideoLinks
B2B-VideoLinks
More VideoLinks >>>