They explode the cell while it is still living inside a plant or animal, vaporize its contents, and sniff. The study appears in online in ACS’ journal Analytical Chemistry: “In Situ Metabolic Profiling of Single Cells by Laser Ablation Electrospray Ionization Mass Spectrometry”.
Akos Vertes and Bindesh Shrestha note that knowing the contents of cells is the key to understanding how healthy cells differ from those in disease. Until now, however, the only way to “look” inside an individual cell was to remove it from its natural environment in an animal or plant, or change its environment. But doing so changed the cell. Scientists never knew whether one cell differed from another because of the disease, or because they had removed it to a new environment.
The new report describes development of a new technique that uses laser pulses focused through a tiny glass fiber to explode a cell and turn its contents into vapor. Scientists then use a laboratory instrument to analyze the vapor and get a profile of the chemicals inside. It can reveal differences between diseased and healthy cells, even between adjacent cells in the same tissue. The scientists used this new technique to analyze the contents of living plant and animal cells and show that it quickly and accurately identified important chemical details that would have been overlooked using conventional techniques.
“In Situ Metabolic Profiling of Single Cells by Laser Ablation Electrospray Ionization Mass Spectrometry”ARTICLE FOR IMMEDIATE RELEASE:
Michael Woods | Newswise Science News
Novel mechanisms of action discovered for the skin cancer medication Imiquimod
21.10.2016 | Technische Universität München
Second research flight into zero gravity
21.10.2016 | Universität Zürich
Researchers from the Institute for Quantum Computing (IQC) at the University of Waterloo led the development of a new extensible wiring technique capable of controlling superconducting quantum bits, representing a significant step towards to the realization of a scalable quantum computer.
"The quantum socket is a wiring method that uses three-dimensional wires based on spring-loaded pins to address individual qubits," said Jeremy Béjanin, a PhD...
In a paper in Scientific Reports, a research team at Worcester Polytechnic Institute describes a novel light-activated phenomenon that could become the basis for applications as diverse as microscopic robotic grippers and more efficient solar cells.
A research team at Worcester Polytechnic Institute (WPI) has developed a revolutionary, light-activated semiconductor nanocomposite material that can be used...
By forcefully embedding two silicon atoms in a diamond matrix, Sandia researchers have demonstrated for the first time on a single chip all the components needed to create a quantum bridge to link quantum computers together.
"People have already built small quantum computers," says Sandia researcher Ryan Camacho. "Maybe the first useful one won't be a single giant quantum computer...
COMPAMED has become the leading international marketplace for suppliers of medical manufacturing. The trade fair, which takes place every November and is co-located to MEDICA in Dusseldorf, has been steadily growing over the past years and shows that medical technology remains a rapidly growing market.
In 2016, the joint pavilion by the IVAM Microtechnology Network, the Product Market “High-tech for Medical Devices”, will be located in Hall 8a again and will...
'Ferroelectric' materials can switch between different states of electrical polarization in response to an external electric field. This flexibility means they show promise for many applications, for example in electronic devices and computer memory. Current ferroelectric materials are highly valued for their thermal and chemical stability and rapid electro-mechanical responses, but creating a material that is scalable down to the tiny sizes needed for technologies like silicon-based semiconductors (Si-based CMOS) has proven challenging.
Now, Hiroshi Funakubo and co-workers at the Tokyo Institute of Technology, in collaboration with researchers across Japan, have conducted experiments to...
14.10.2016 | Event News
14.10.2016 | Event News
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21.10.2016 | Materials Sciences