Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Exploration by Explosion: Studying the Inner Realm of Living Cells

13.11.2009
Scientists in Washington, DC, are reporting development and successful tests of a new way for exploring the insides of living cells, the microscopic building blocks of all known plants and animals.

They explode the cell while it is still living inside a plant or animal, vaporize its contents, and sniff. The study appears in online in ACS’ journal Analytical Chemistry: “In Situ Metabolic Profiling of Single Cells by Laser Ablation Electrospray Ionization Mass Spectrometry”.

Akos Vertes and Bindesh Shrestha note that knowing the contents of cells is the key to understanding how healthy cells differ from those in disease. Until now, however, the only way to “look” inside an individual cell was to remove it from its natural environment in an animal or plant, or change its environment. But doing so changed the cell. Scientists never knew whether one cell differed from another because of the disease, or because they had removed it to a new environment.

The new report describes development of a new technique that uses laser pulses focused through a tiny glass fiber to explode a cell and turn its contents into vapor. Scientists then use a laboratory instrument to analyze the vapor and get a profile of the chemicals inside. It can reveal differences between diseased and healthy cells, even between adjacent cells in the same tissue. The scientists used this new technique to analyze the contents of living plant and animal cells and show that it quickly and accurately identified important chemical details that would have been overlooked using conventional techniques.

“In Situ Metabolic Profiling of Single Cells by Laser Ablation Electrospray Ionization Mass Spectrometry”

ARTICLE FOR IMMEDIATE RELEASE:
http://pubs.acs.org/stoken/presspac/presspac/full/10.1021/ac901525g

Michael Woods | Newswise Science News
Further information:
http://www.acs.org
http://pubs.acs.org/stoken/presspac/presspac/full/10.1021/ac901525g

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: In best circles: First integrated circuit from self-assembled polymer

For the first time, a team of researchers at the Max-Planck Institute (MPI) for Polymer Research in Mainz, Germany, has succeeded in making an integrated circuit (IC) from just a monolayer of a semiconducting polymer via a bottom-up, self-assembly approach.

In the self-assembly process, the semiconducting polymer arranges itself into an ordered monolayer in a transistor. The transistors are binary switches used...

Im Focus: Demonstration of a single molecule piezoelectric effect

Breakthrough provides a new concept of the design of molecular motors, sensors and electricity generators at nanoscale

Researchers from the Institute of Organic Chemistry and Biochemistry of the CAS (IOCB Prague), Institute of Physics of the CAS (IP CAS) and Palacký University...

Im Focus: Hybrid optics bring color imaging using ultrathin metalenses into focus

For photographers and scientists, lenses are lifesavers. They reflect and refract light, making possible the imaging systems that drive discovery through the microscope and preserve history through cameras.

But today's glass-based lenses are bulky and resist miniaturization. Next-generation technologies, such as ultrathin cameras or tiny microscopes, require...

Im Focus: Stem cell divisions in the adult brain seen for the first time

Scientists from the University of Zurich have succeeded for the first time in tracking individual stem cells and their neuronal progeny over months within the intact adult brain. This study sheds light on how new neurons are produced throughout life.

The generation of new nerve cells was once thought to taper off at the end of embryonic development. However, recent research has shown that the adult brain...

Im Focus: Interference as a new method for cooling quantum devices

Theoretical physicists propose to use negative interference to control heat flow in quantum devices. Study published in Physical Review Letters

Quantum computer parts are sensitive and need to be cooled to very low temperatures. Their tiny size makes them particularly susceptible to a temperature...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

VideoLinks
Industry & Economy
Event News

2nd International Conference on High Temperature Shape Memory Alloys (HTSMAs)

15.02.2018 | Event News

Aachen DC Grid Summit 2018

13.02.2018 | Event News

How Global Climate Policy Can Learn from the Energy Transition

12.02.2018 | Event News

 
Latest News

Researchers invent tiny, light-powered wires to modulate brain's electrical signals

21.02.2018 | Life Sciences

The “Holy Grail” of peptide chemistry: Making peptide active agents available orally

21.02.2018 | Life Sciences

Atomic structure of ultrasound material not what anyone expected

21.02.2018 | Materials Sciences

VideoLinks
Science & Research
Overview of more VideoLinks >>>