Toward an explanation for Crohn's disease?
Twenty-five per cent of Crohn's disease patients have a mutation in what is called the NOD2 gene, but it is not precisely known how this mutation influences the disease.
The latest study by Dr. Marcel Behr, of the Research Institute of the MUHC and McGill University, has provided new insight into how this might occur. The study will be published on July 9th in the Journal of Experimental Medicine.
When the NOD2 gene functions normally, it codes for a receptor that will recognize invading bacteria and then trigger the immune response. This study demonstrates that the NOD2 receptor preferentially recognizes a peptide called N-glycolyl-MDP, which is only found in a specific family of bacteria called mycobacteria. When mycobacteria invade the human body, they cause an immediate and very strong immune response via the NOD2 receptor.
“Now that we have a better understanding of the normal role of NOD2, we think that a mutation in this gene prevents mycobacteria from being properly recognized by the immune system,” explained Dr. Behr. “If mycobacteria are not recognized, the body cannot effectively fight them off and then becomes persistently infected.”
Researchers were already aware of the relationship between mycobacteria and Crohn's disease, but they did not know whether the presence of bacteria was a cause or a consequence of the disease. This new discovery associates the predisposition for Crohn's disease with both the NOD2 mutation and the presence of mycobacteria, but researchers must still determine the precise combination of these factors to understand how the disease develops.
More research is required to establish a complete explanation. From this, it is expected that new therapeutic approaches that fight the cause of Crohn's disease may be developed
Dr. Marcel Behr
Dr. Marcel Behr is a researcher in the Infection and Immunity Axis at the Research Institute of the MUHC and an Associate Professor of Medicine and William Dawson Scholar of McGill University.
Funding
This study was funded by a grant from the Canadian Institutes of Health Research (CIHR). The salaries of some researchers were provided by the Fonds de la recherche en santé du Québec.
Partners
This article was co-authored by François Coulombe, Maziar Divanghi, Frédéric Veyrier, Louis de Léséleuc, Dr. Michael B. Reed and Dr Marcel Behr from the Research Institute of the MUHC; James L. Gleason of McGill University; and Yibin Yang, Michelle A. Kelliher, Amit K. Pandey, and Christopher M. Sassetti of the University of Massachusetts Medical School.
Media Contact
More Information:
http://www.muhc.mcgill.caAll latest news from the category: Life Sciences and Chemistry
Articles and reports from the Life Sciences and chemistry area deal with applied and basic research into modern biology, chemistry and human medicine.
Valuable information can be found on a range of life sciences fields including bacteriology, biochemistry, bionics, bioinformatics, biophysics, biotechnology, genetics, geobotany, human biology, marine biology, microbiology, molecular biology, cellular biology, zoology, bioinorganic chemistry, microchemistry and environmental chemistry.
Newest articles
Bringing bio-inspired robots to life
Nebraska researcher Eric Markvicka gets NSF CAREER Award to pursue manufacture of novel materials for soft robotics and stretchable electronics. Engineers are increasingly eager to develop robots that mimic the…
Bella moths use poison to attract mates
Scientists are closer to finding out how. Pyrrolizidine alkaloids are as bitter and toxic as they are hard to pronounce. They’re produced by several different types of plants and are…
AI tool creates ‘synthetic’ images of cells
…for enhanced microscopy analysis. Observing individual cells through microscopes can reveal a range of important cell biological phenomena that frequently play a role in human diseases, but the process of…