Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Evolution by mistake

26.01.2011
Charles Darwin based his groundbreaking theory of natural selection on the realization that genetic variation among organisms is the key to evolution.

Some individuals are better adapted to a given environment than others, making them more likely to survive and pass on their genes to future generations. But exactly how nature creates variation in the first place still poses somewhat of a puzzle to evolutionary biologists.

Now, Joanna Masel, associate professor in the UA's department of ecology and evolutionary biology, and postdoctoral fellow Etienne Rajon discovered the ways organisms deal with mistakes that occur while the genetic code in their cells is being interpreted greatly influences their ability to adapt to new environmental conditions – in other words, their ability to evolve.

"Evolution needs a playground in order to try things out," Masel said. "It's like in competitive business: New products and ideas have to be tested to see whether they can live up to the challenge."

The finding is reported in a paper published in the journal Proceedings of the National Academy of Sciences.

In nature, it turns out, many new traits that, for example, enable their bearers to conquer new habitats, start out as blunders: mistakes made by cells that result in altered proteins with changed properties or functions that are new altogether, even when there is nothing wrong with the gene itself. Sometime later, one of these mistakes can get into the gene and become more permanent.

"If the mechanisms interpreting genetic information were completely flawless, organisms would stay the same all the time and be unable to adapt to new situations or changes in their environment," said Masel, who is also a member of the UA's BIO5 Institute.

Living beings face two options of handling the dangers posed by errors, Masel and Rajon wrote. One is to avoid making errors in the first place, for example by having a proofreading mechanism to spot and fix errors as they arise. The authors call this a global solution, since it is not specific to any particular mistake, but instead watches over the entire process.

The alternative is to allow errors to happen, but evolve robustness to the effects of each of them. Masel and Rajon call this strategy a local solution, because in the absence of a global proofreading mechanism, it requires an organism to be resilient to each and every mistake that pops up.

"We discovered that extremely small populations will evolve global solutions, while very large populations will evolve local solutions," Masel said. "Most realistically sized populations can go either direction but will gravitate toward one or the other. But once they do, they rarely switch, even over the course of evolutionary time."

Using what is known about yeast, a popular model organism in basic biological research, Masel and Rajon formulated a mathematical model and ran computer simulations of genetic change in populations.

Avoiding or fixing errors comes at a cost, they pointed out. If it didn't, organisms would have evolved nearly error-free accuracy in translating genetic information into proteins. Instead, there is a trade-off between the cost of keeping proteins free of errors and the risk of allowing potentially deleterious mistakes.

In previous publications, Masel's group introduced the idea of variation within a population producing "hopeful and hopeless monsters" – organisms with genetic changes whose consequences can be either mostly harmless or deadly, but rarely in between.

In the present paper, Masel and Rajon report that natural variation comes in two flavors: regular variation, which is generally bad most of the time, since the odds of a genetic mutation leading to something useful or even better are pretty slim, and what they call cryptic variation, which is less likely to be deadly, and more likely to be mostly harmless.

So how does cryptic variation work and why is it so important for understanding evolution?

By allowing for a certain amount of mistakes to occur instead of quenching them with global proofreading machinery, organisms gain the advantage of allowing for what Masel calls pre-selection: It provides an opportunity for natural selection to act on sequences even before mutations occur.

"There is evidence that cryptic gene sequences still get translated into protein," Masel explained, "at least occasionally."

"When those proteins are bad enough, the sequences that produce them can be selected against. For example, if we imagine a protein with an altered amino acid sequence causing it to not fold correctly and pile up inside the cell, that would be very toxic to the organism."

"In this case of a misfolded protein, selection would favor mutations causing that genetic sequence to not be translated into protein or it would favor sequences in which there is a change so that even if that protein is made by accident, the altered sequence would be harmless."

"Pre-selection puts that cryptic variation in a state of readiness," Masel said. "One could think of local solutions as natural selection going on behind the scenes, weeding out variations that are going to be catastrophic, and enriching others that are only slightly bad or even harmless."

"Whatever is left after this process of pre-selection has to be better," she pointed out. "Therefore, populations relying on this strategy have a greater capability to evolve in response to new challenges. With too much proofreading, that pre-selection can't happen."

"Most populations are fairly well adapted and from an evolutionary perspective get no benefit from lots of variation. Having variation in a cryptic form gets around that because the organism doesn't pay a large cost for it, but it's still there if it needs it."

According to Masel, studying how nature creates innovation holds clues for human society as well.

"We find that biology has a clever solution. It lets lots of ideas flourish, but only in a cryptic form and even while it's cryptic, it weeds out the worst ideas. This is an extremely powerful and successful strategy. I think companies, governments, economics in general can learn a lot on how to foster innovation from understanding how biological innovation works."

This study was funded by the National Institutes of Health, or NIH, and through a scholarship awarded to Masel by the Pew Charitable Trusts.

Daniel Stolte | EurekAlert!
Further information:
http://www.arizona.edu

More articles from Life Sciences:

nachricht What the world's tiniest 'monster truck' reveals
23.08.2017 | American Chemical Society

nachricht Treating arthritis with algae
23.08.2017 | Empa - Eidgenössische Materialprüfungs- und Forschungsanstalt

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Fizzy soda water could be key to clean manufacture of flat wonder material: Graphene

Whether you call it effervescent, fizzy, or sparkling, carbonated water is making a comeback as a beverage. Aside from quenching thirst, researchers at the University of Illinois at Urbana-Champaign have discovered a new use for these "bubbly" concoctions that will have major impact on the manufacturer of the world's thinnest, flattest, and one most useful materials -- graphene.

As graphene's popularity grows as an advanced "wonder" material, the speed and quality at which it can be manufactured will be paramount. With that in mind,...

Im Focus: Exotic quantum states made from light: Physicists create optical “wells” for a super-photon

Physicists at the University of Bonn have managed to create optical hollows and more complex patterns into which the light of a Bose-Einstein condensate flows. The creation of such highly low-loss structures for light is a prerequisite for complex light circuits, such as for quantum information processing for a new generation of computers. The researchers are now presenting their results in the journal Nature Photonics.

Light particles (photons) occur as tiny, indivisible portions. Many thousands of these light portions can be merged to form a single super-photon if they are...

Im Focus: Circular RNA linked to brain function

For the first time, scientists have shown that circular RNA is linked to brain function. When a RNA molecule called Cdr1as was deleted from the genome of mice, the animals had problems filtering out unnecessary information – like patients suffering from neuropsychiatric disorders.

While hundreds of circular RNAs (circRNAs) are abundant in mammalian brains, one big question has remained unanswered: What are they actually good for? In the...

Im Focus: RAVAN CubeSat measures Earth's outgoing energy

An experimental small satellite has successfully collected and delivered data on a key measurement for predicting changes in Earth's climate.

The Radiometer Assessment using Vertically Aligned Nanotubes (RAVAN) CubeSat was launched into low-Earth orbit on Nov. 11, 2016, in order to test new...

Im Focus: Scientists shine new light on the “other high temperature superconductor”

A study led by scientists of the Max Planck Institute for the Structure and Dynamics of Matter (MPSD) at the Center for Free-Electron Laser Science in Hamburg presents evidence of the coexistence of superconductivity and “charge-density-waves” in compounds of the poorly-studied family of bismuthates. This observation opens up new perspectives for a deeper understanding of the phenomenon of high-temperature superconductivity, a topic which is at the core of condensed matter research since more than 30 years. The paper by Nicoletti et al has been published in the PNAS.

Since the beginning of the 20th century, superconductivity had been observed in some metals at temperatures only a few degrees above the absolute zero (minus...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

Call for Papers – ICNFT 2018, 5th International Conference on New Forming Technology

16.08.2017 | Event News

Sustainability is the business model of tomorrow

04.08.2017 | Event News

Clash of Realities 2017: Registration now open. International Conference at TH Köln

26.07.2017 | Event News

 
Latest News

What the world's tiniest 'monster truck' reveals

23.08.2017 | Life Sciences

Treating arthritis with algae

23.08.2017 | Life Sciences

Witnessing turbulent motion in the atmosphere of a distant star

23.08.2017 | Physics and Astronomy

VideoLinks
B2B-VideoLinks
More VideoLinks >>>