Within a large international collaborative study, lead by Norbert Hübner (Max-Delbrück-Centrum für Molekulare Medizin (MDC) in Berlin-Buch, Germany) and Stuart Cook (Imperial College London, UK), European scientists have now identified a gene network modulating type 1 diabetes risk. Furthermore, the scientists identified a key receptor within this important genetic framework.
The current multidimenstional approach was based on genetic as well as gene expression data in different species and provided new insights in respect that the innate viral response pathway and immune cells called macrophages are also implicated in T1D.
Transcription factors play a major role in regulating gene expression by binding to specific target sequences close to the gene of interest. Importantly, a transcription factor often regulates not only one gene but whole gene networks. “In recent years a multiplicity of risk genes has been discovered which play an important role in the development of various diseases. Despite this, though, the molecular mechanism that influences the onset of the diseases has not yet been fully understood” explains a leader of this currently published study, Prof. Dr. Norbert Huebner. “We have identified a transcription factor which controls a gene network in which a well known Diabetes mellitus Type 1 risk gene occurs.
“Further analysis of the data”, concluded Prof. Huebner, “revealed that the IDIN (interferon regulatory factor 7 (IRF71)-driven inflammatory network ) gene essentially influences Diabetes mellitus type 1 risk via the receptor EBI2 which regulates IDIN and thus plays a role in the development of this autoimmune disease. Additionally we were able to show the involvement of macrophages in the pathogenesis as well as able to show that similar signaling pathways are involved in Diabetes mellitus type 1 and Epstein Barr virus infection.”
More broadly, the study is of interest because it successfully combines gene networks and DNA sequence variation to emphasize the fact that regulatory regions that perturb biological networks can have an important role in disease risk.
“The present study is an extraordinary example of combining different genetic approaches, involving genome wide expression data from rats and humans as well as genome wide association data resulting in new and exciting insights into disease pathogenesis” explained Prof. Dr. Heribert Schunkert, coordinator of Cardiogenics. “In addition, it is a success story based on international collaboration between working groups and consortia with very different expertise” adds Prof. Dr. Jeanette Erdmann, scientific project manager of Cardiogenics.
The Cardiogenics consortium (www.cardiogenics.eu) has played its role in this work bringing experimental monocyte and macrophage expression data and expertise from its own focus on the assessment of heart attack risk to aid understanding of another important common disease. This EU project has gathered together leading research groups from six countries (Germany, United Kingdom, France, The Netherlands, Sweden, and Italy) to build a multi-disciplinary team to meet the challenge of improving cardiovascular healthcare. In addition to clinical teams, the consortium consists of academic groups specialized in human genetics, genetic epidemiology, bioinformatics, transcriptomics, and proteomics. In addition, the consortium has been supported by the Welcome Trust Sanger Institute, Europe's premier genome centre.A trans-acting locus regulates an anti-viral expression network and type 1 diabetes risk
M. Heinig*, E. Petretto*, C. Wallace, L. Bottolo, M. Rotival, H. Lu, Y. Li, R. Sarwar, S.R. Langley, A. Bauerfeind, O. Hummel, Y.-A. Lee, S. Paskas, C. Rintisch, K. Saar, .J Cooper, R. Buchan, E.E. Gray, J.G. Cyster, Cardiogenics Consortium, J. Erdmann, C. Hengstenberg, S. Maouche, W.H. Ouwehand, C.M. Rice, N.J. Samani, H. Schunkert, A.H. Goodall, H. Schulz, H. Roider, M. Vingron, S. Blankenberg, T. Münzel, T. Zeller, S. Szymczak, A. Ziegler, L. Tiret, D.J. Smyth, M. Pravenec, T.J. Aitman, F. Cambien, D. Clayton, J.A. Todd, N. Hubner* und S.A. Cook* (*contributed equally)
Nature advance online publication 08.09.2010: http://www.nature.com/Contact
Researchers uncover protein-based “cancer signature”
05.12.2016 | Universität Basel
The Nagoya Protocol Creates Disadvantages for Many Countries when Applied to Microorganisms
05.12.2016 | Leibniz-Institut DSMZ-Deutsche Sammlung von Mikroorganismen und Zellkulturen GmbH
Have you ever wondered how you see the world? Vision is about photons of light, which are packets of energy, interacting with the atoms or molecules in what...
A multi-institutional research collaboration has created a novel approach for fabricating three-dimensional micro-optics through the shape-defined formation of porous silicon (PSi), with broad impacts in integrated optoelectronics, imaging, and photovoltaics.
Working with colleagues at Stanford and The Dow Chemical Company, researchers at the University of Illinois at Urbana-Champaign fabricated 3-D birefringent...
In experiments with magnetic atoms conducted at extremely low temperatures, scientists have demonstrated a unique phase of matter: The atoms form a new type of quantum liquid or quantum droplet state. These so called quantum droplets may preserve their form in absence of external confinement because of quantum effects. The joint team of experimental physicists from Innsbruck and theoretical physicists from Hannover report on their findings in the journal Physical Review X.
“Our Quantum droplets are in the gas phase but they still drop like a rock,” explains experimental physicist Francesca Ferlaino when talking about the...
The Max Planck Institute for Physics (MPP) is opening up a new research field. A workshop from November 21 - 22, 2016 will mark the start of activities for an innovative axion experiment. Axions are still only purely hypothetical particles. Their detection could solve two fundamental problems in particle physics: What dark matter consists of and why it has not yet been possible to directly observe a CP violation for the strong interaction.
The “MADMAX” project is the MPP’s commitment to axion research. Axions are so far only a theoretical prediction and are difficult to detect: on the one hand,...
Broadband rotational spectroscopy unravels structural reshaping of isolated molecules in the gas phase to accommodate water
In two recent publications in the Journal of Chemical Physics and in the Journal of Physical Chemistry Letters, researchers around Melanie Schnell from the Max...
16.11.2016 | Event News
01.11.2016 | Event News
14.10.2016 | Event News
05.12.2016 | Power and Electrical Engineering
05.12.2016 | Materials Sciences
05.12.2016 | Power and Electrical Engineering