Epigenetics provides new insights into the pathogenesis of lymphoma

Epigenetics provides new insights into the pathogenesis of lymphoma

In collaboration with scientists from the Austrian Institute of Technology (AIT), the University of Cambridge and the University of Southern California (USC), molecular biologist Melanie Hassler from the working group led by Gerda Egger (Department of Pathology at MedUni Vienna, Division of Experimental Pathology, Head: Lukas Kenner) has analysed the methylation pattern of Anaplastic Large Cell Lymphoma (ALCL), an aggressive non-Hodgkin lymphoma that primarily affects children and young adults. ALCL is a very aggressive form of leukaemia, which usually manifests itself as tumours in the lymph nodes, skin, lungs, liver and soft tissues. 

However, in the paper that was recently published in the leading journal “Cell Reports”, the researchers were able to use the methylation pattern to show that – contrary to what we previously thought – ALCL resembles early T-cell development in the thymus gland, which is part of the lymphatic system. Moreover, due to epigenetic silencing, these lymphomas lack important T-cell-specific factors for cell development and differentiation. Hassler explains: “Certain drugs that interfere in the methylation programme of cancer cells could be used in future to adjust the methylation pattern of ALCL cells to that of healthy T-cells, thereby arresting tumour growth.”

A better understanding of ALCL

Egger: “The results of this study have given us a better understanding of the development of ALCL in children and adolescents, so that in future we will be able to attack cancer cells in a targeted way, using epigenetic therapies. Furthermore, decoding of the methylation pattern of ALCL provides us with a basis for establishing biomarkers in the area of personalised and translational medicine.” Gerda Egger heads up the epigenetics working group at the Department of Pathology and is Deputy Director at the Ludwig Boltzmann Institute for Applied Diagnostics.

Full bibliographic information

Cell Reports
„Insights into the pathogenesis of Anaplastic Large Cell Lymphoma through genome-wide DNA methylation profiling.“ Melanie R. Hassler, Walter Pulverer, Ranjani Lakshminarasimhan, Elisa Redl, Julia Hacker, Gavin D. Garland, Olaf Merkel, Ana-Iris Schiefer, Ingrid Simonitsch-Klupp, Lukas Kenner, Daniel J. Weisenberger, Andreas Weinhaeusel, Suzanne D. Turner and Gerda Egger, Cell Reports, 2016, 17:1-13;
http://dx.doi.org/10.1016/j.celrep.2016.09.018

http://www.meduniwien.ac.at

Media Contact

Johannes Angerer AlphaGalileo

All latest news from the category: Life Sciences and Chemistry

Articles and reports from the Life Sciences and chemistry area deal with applied and basic research into modern biology, chemistry and human medicine.

Valuable information can be found on a range of life sciences fields including bacteriology, biochemistry, bionics, bioinformatics, biophysics, biotechnology, genetics, geobotany, human biology, marine biology, microbiology, molecular biology, cellular biology, zoology, bioinorganic chemistry, microchemistry and environmental chemistry.

Back to home

Comments (0)

Write a comment

Newest articles

New yttrium-hydrogen compounds discovered

Researchers at the University of Bayreuth have made a significant scientific breakthrough by discovering new yttrium-hydrogen compounds having serious implications for the research on high-pressure superconductivity. High-pressure superconductivity refers to…

New AI model detects ninety percent of lymphatic cancer cases

Medical image analysis using AI has developed rapidly in recent years. Now, one of the largest studies to date has been carried out using AI-assisted image analysis of lymphoma, cancer…

UTA preps giant particle detectors for neutrino project

Excavation of caverns part of Fermilab’s Deep Underground Neutrino Experiment. With excavation work complete at the site where four gigantic particle detectors for the international Deep Underground Neutrino Experiment (DUNE) will be…

Partners & Sponsors