Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Epigenetics provides new insights into the pathogenesis of lymphoma

05.10.2016

Cancer cells have a different DNA methylation pattern from that of healthy cells. These patterns can be used to explain tumour-specific deviations in gene expression and to identify biomarkers for the detection of tumours, as well as associated prognosis and treatment planning. This is all possible thanks to epigenetics. Epigenetics looks at special regulation mechanisms, such as DNA methylation and histone modifications, which determine the gene expression pattern of different types of cell and are passed on to daughter cells, without there being any specific changes to the DNA base sequence. Using this technology, it is now also possible to identify the original tumour cells, by comparing them with healthy cells.

In collaboration with scientists from the Austrian Institute of Technology (AIT), the University of Cambridge and the University of Southern California (USC), molecular biologist Melanie Hassler from the working group led by Gerda Egger (Department of Pathology at MedUni Vienna, Division of Experimental Pathology, Head: Lukas Kenner) has analysed the methylation pattern of Anaplastic Large Cell Lymphoma (ALCL), an aggressive non-Hodgkin lymphoma that primarily affects children and young adults. ALCL is a very aggressive form of leukaemia, which usually manifests itself as tumours in the lymph nodes, skin, lungs, liver and soft tissues. 


Epigenetics provides new insights into the pathogenesis of lymphoma

However, in the paper that was recently published in the leading journal "Cell Reports", the researchers were able to use the methylation pattern to show that – contrary to what we previously thought – ALCL resembles early T-cell development in the thymus gland, which is part of the lymphatic system. Moreover, due to epigenetic silencing, these lymphomas lack important T-cell-specific factors for cell development and differentiation. Hassler explains: "Certain drugs that interfere in the methylation programme of cancer cells could be used in future to adjust the methylation pattern of ALCL cells to that of healthy T-cells, thereby arresting tumour growth."

A better understanding of ALCL

Egger: "The results of this study have given us a better understanding of the development of ALCL in children and adolescents, so that in future we will be able to attack cancer cells in a targeted way, using epigenetic therapies. Furthermore, decoding of the methylation pattern of ALCL provides us with a basis for establishing biomarkers in the area of personalised and translational medicine." Gerda Egger heads up the epigenetics working group at the Department of Pathology and is Deputy Director at the Ludwig Boltzmann Institute for Applied Diagnostics.

Full bibliographic information

Cell Reports
„Insights into the pathogenesis of Anaplastic Large Cell Lymphoma through genome-wide DNA methylation profiling.“ Melanie R. Hassler, Walter Pulverer, Ranjani Lakshminarasimhan, Elisa Redl, Julia Hacker, Gavin D. Garland, Olaf Merkel, Ana-Iris Schiefer, Ingrid Simonitsch-Klupp, Lukas Kenner, Daniel J. Weisenberger, Andreas Weinhaeusel, Suzanne D. Turner and Gerda Egger, Cell Reports, 2016, 17:1-13;
http://dx.doi.org/10.1016/j.celrep.2016.09.018

http://www.meduniwien.ac.at

Johannes Angerer | AlphaGalileo

More articles from Life Sciences:

nachricht Link Discovered between Immune System, Brain Structure and Memory
26.04.2017 | Universität Basel

nachricht Researchers develop eco-friendly, 4-in-1 catalyst
25.04.2017 | Brown University

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Making lightweight construction suitable for series production

More and more automobile companies are focusing on body parts made of carbon fiber reinforced plastics (CFRP). However, manufacturing and repair costs must be further reduced in order to make CFRP more economical in use. Together with the Volkswagen AG and five other partners in the project HolQueSt 3D, the Laser Zentrum Hannover e.V. (LZH) has developed laser processes for the automatic trimming, drilling and repair of three-dimensional components.

Automated manufacturing processes are the basis for ultimately establishing the series production of CFRP components. In the project HolQueSt 3D, the LZH has...

Im Focus: Wonder material? Novel nanotube structure strengthens thin films for flexible electronics

Reflecting the structure of composites found in nature and the ancient world, researchers at the University of Illinois at Urbana-Champaign have synthesized thin carbon nanotube (CNT) textiles that exhibit both high electrical conductivity and a level of toughness that is about fifty times higher than copper films, currently used in electronics.

"The structural robustness of thin metal films has significant importance for the reliable operation of smart skin and flexible electronics including...

Im Focus: Deep inside Galaxy M87

The nearby, giant radio galaxy M87 hosts a supermassive black hole (BH) and is well-known for its bright jet dominating the spectrum over ten orders of magnitude in frequency. Due to its proximity, jet prominence, and the large black hole mass, M87 is the best laboratory for investigating the formation, acceleration, and collimation of relativistic jets. A research team led by Silke Britzen from the Max Planck Institute for Radio Astronomy in Bonn, Germany, has found strong indication for turbulent processes connecting the accretion disk and the jet of that galaxy providing insights into the longstanding problem of the origin of astrophysical jets.

Supermassive black holes form some of the most enigmatic phenomena in astrophysics. Their enormous energy output is supposed to be generated by the...

Im Focus: A Quantum Low Pass for Photons

Physicists in Garching observe novel quantum effect that limits the number of emitted photons.

The probability to find a certain number of photons inside a laser pulse usually corresponds to a classical distribution of independent events, the so-called...

Im Focus: Microprocessors based on a layer of just three atoms

Microprocessors based on atomically thin materials hold the promise of the evolution of traditional processors as well as new applications in the field of flexible electronics. Now, a TU Wien research team led by Thomas Müller has made a breakthrough in this field as part of an ongoing research project.

Two-dimensional materials, or 2D materials for short, are extremely versatile, although – or often more precisely because – they are made up of just one or a...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

Expert meeting “Health Business Connect” will connect international medical technology companies

20.04.2017 | Event News

Wenn der Computer das Gehirn austrickst

18.04.2017 | Event News

7th International Conference on Crystalline Silicon Photovoltaics in Freiburg on April 3-5, 2017

03.04.2017 | Event News

 
Latest News

Scientist invents way to trigger artificial photosynthesis to clean air

26.04.2017 | Materials Sciences

Ammonium nitrogen input increases the synthesis of anticarcinogenic compounds in broccoli

26.04.2017 | Agricultural and Forestry Science

SwRI-led team discovers lull in Mars' giant impact history

26.04.2017 | Physics and Astronomy

VideoLinks
B2B-VideoLinks
More VideoLinks >>>