Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Enzyme new potential target in treating blood cancer

22.08.2008
A discovery by a research team with the Sahlgrenska Academy at Gothenburg University in Sweden may lead to new treatments for blood cancer and other diseases. By stopping the production of a specific enzyme, ICMT, researchers were able to alleviate disease symptoms in mice with blood cancer.

In many forms of cancer, the growth of tumors and their ability to spread are stimulated by a mutated gene that codes for a so-called RAS protein. This has led to intensive research into how to block the activity of these proteins.

“RAS proteins exist in all cells, anchored to the inside of the cell membrane, where they regulate cell growth and cell division. The enzyme we are studying helps RAS proteins get anchored to the cell membrane. By blocking this enzyme, we were able to inhibit the binding of RAS proteins to cell membranes and greatly improve the disease symptoms in mice with blood cancer,” says Associate Professor Martin Bergö, who directs research at the Wallberg? Laboratory at the Sahlgrenska Academy.

The research team has developed a genetically modified mouse that produces a mutated and constantly active RAS protein in its bone marrow, where new blood cells are generated. These mice develop a form of leukemia that is similar to a number of forms of blood cancer in humans. The pathogenic bone marrow cells divide uncontrollably, and the normal control of cell growth cannot turn them off. In these mice, the production of the enzyme called ICMT can also be stopped.

... more about:
»ICMT »RAS protein »Ras »enzyme »marrow

“When we inhibited the production of the enzyme, the development of blood cancer declined, and the uncontrolled growth of bone marrow cells was blocked. Another discovery was that normal bone marrow cells were not significantly affected by the ICMT enzyme. The means that future drugs for inhibiting ICMT could specifically target the pathogenic cells and leave normal cells intact. A drub that blocks this enzyme could be an effective future cancer treatment,” says Martin Bergö.

The research team also demonstrated that mice with an aggressive form of lung cancer lived longer and developed considerably smaller tumors when the ICMT enzyme was blocked. But even though the study strongly indicates that ICMT can be an effective target for cancer treatment, the findings now need to be corroborated by other mice with blood cancer and lung cancer, and drugs to inhibit the enzyme need to be produced and tested.

Ulrika Lundin | alfa
Further information:
http:// www.vr.se/
http://bloodjournal.hematologylibrary.org/cgi/content/abstract/112/4/1357

Further reports about: ICMT RAS protein Ras enzyme marrow

More articles from Life Sciences:

nachricht 127 at one blow...
18.01.2017 | Stiftung Zoologisches Forschungsmuseum Alexander Koenig, Leibniz-Institut für Biodiversität der Tiere

nachricht How gut bacteria can make us ill
18.01.2017 | Helmholtz-Zentrum für Infektionsforschung

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: How gut bacteria can make us ill

HZI researchers decipher infection mechanisms of Yersinia and immune responses of the host

Yersiniae cause severe intestinal infections. Studies using Yersinia pseudotuberculosis as a model organism aim to elucidate the infection mechanisms of these...

Im Focus: Interfacial Superconductivity: Magnetic and superconducting order revealed simultaneously

Researchers from the University of Hamburg in Germany, in collaboration with colleagues from the University of Aarhus in Denmark, have synthesized a new superconducting material by growing a few layers of an antiferromagnetic transition-metal chalcogenide on a bismuth-based topological insulator, both being non-superconducting materials.

While superconductivity and magnetism are generally believed to be mutually exclusive, surprisingly, in this new material, superconducting correlations...

Im Focus: Studying fundamental particles in materials

Laser-driving of semimetals allows creating novel quasiparticle states within condensed matter systems and switching between different states on ultrafast time scales

Studying properties of fundamental particles in condensed matter systems is a promising approach to quantum field theory. Quasiparticles offer the opportunity...

Im Focus: Designing Architecture with Solar Building Envelopes

Among the general public, solar thermal energy is currently associated with dark blue, rectangular collectors on building roofs. Technologies are needed for aesthetically high quality architecture which offer the architect more room for manoeuvre when it comes to low- and plus-energy buildings. With the “ArKol” project, researchers at Fraunhofer ISE together with partners are currently developing two façade collectors for solar thermal energy generation, which permit a high degree of design flexibility: a strip collector for opaque façade sections and a solar thermal blind for transparent sections. The current state of the two developments will be presented at the BAU 2017 trade fair.

As part of the “ArKol – development of architecturally highly integrated façade collectors with heat pipes” project, Fraunhofer ISE together with its partners...

Im Focus: How to inflate a hardened concrete shell with a weight of 80 t

At TU Wien, an alternative for resource intensive formwork for the construction of concrete domes was developed. It is now used in a test dome for the Austrian Federal Railways Infrastructure (ÖBB Infrastruktur).

Concrete shells are efficient structures, but not very resource efficient. The formwork for the construction of concrete domes alone requires a high amount of...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

12V, 48V, high-voltage – trends in E/E automotive architecture

10.01.2017 | Event News

2nd Conference on Non-Textual Information on 10 and 11 May 2017 in Hannover

09.01.2017 | Event News

Nothing will happen without batteries making it happen!

05.01.2017 | Event News

 
Latest News

Explaining how 2-D materials break at the atomic level

18.01.2017 | Materials Sciences

Data analysis optimizes cyber-physical systems in telecommunications and building automation

18.01.2017 | Information Technology

Reducing household waste with less energy

18.01.2017 | Ecology, The Environment and Conservation

VideoLinks
B2B-VideoLinks
More VideoLinks >>>