Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Enzyme discovery paves way to tackling deadly parasite diseases

25.09.2014

An enzyme found in all living things could hold the key to combatting deadly diseases such as sleeping sickness, a study suggests.

Research into the enzyme, which helps cells convert nutrients into energy, has shown that it is activated in different ways in various species.

Researchers say this discovery creates an opportunity to design drugs that block activity of the enzyme – known as pyruvate kinase – in species that cause infection. Blocking the enzyme would effectively kill the parasite, without affecting the same enzyme in the patient.

Findings from the study could lead to new treatments for diseases spread by parasites – including sleeping sickness and Chagas disease – that affect millions of people in the developing world.

Researchers say the finding could ultimately help tackle a range of healthcare problems, including antibiotic resistance and some forms of cancer.

Scientists used a range of analytical techniques to discover how pyruvate kinase functions in parasites, mammals and bacteria.

They found that the enzyme becomes active in all species in a similar way. A small sugar molecule binds to the enzyme to kick-start the process of nutrient absorption. But each species has a unique mechanism for activating the enzyme, providing opportunities to design drugs that block its activity in individual species.

The study is published in the first edition of the journal Royal Society Open Science.

###

The work was funded by the Medical Research Council, Wellcome Trust, Scottish University Life Sciences Alliance and Biotechnology and Biological Sciences Research Council.

Professor Malcolm Walkinshaw, Chair of Structural Biology at the University of Edinburgh, who led the study, said: "With this discovery, we've found an Achilles heel for sleeping sickness and many other conditions. Fresh discoveries about this key enzyme – pyruvate kinase – could enable the design of treatments to tackle disease without harm to the patient."

Catriona Kelly | Eurek Alert!

More articles from Life Sciences:

nachricht Molecular evolution: How the building blocks of life may form in space
26.04.2018 | American Institute of Physics

nachricht Multifunctional bacterial microswimmer able to deliver cargo and destroy itself
26.04.2018 | Max-Planck-Institut für Intelligente Systeme

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Why we need erasable MRI scans

New technology could allow an MRI contrast agent to 'blink off,' helping doctors diagnose disease

Magnetic resonance imaging, or MRI, is a widely used medical tool for taking pictures of the insides of our body. One way to make MRI scans easier to read is...

Im Focus: BAM@Hannover Messe: innovative 3D printing method for space flight

At the Hannover Messe 2018, the Bundesanstalt für Materialforschung und-prüfung (BAM) will show how, in the future, astronauts could produce their own tools or spare parts in zero gravity using 3D printing. This will reduce, weight and transport costs for space missions. Visitors can experience the innovative additive manufacturing process live at the fair.

Powder-based additive manufacturing in zero gravity is the name of the project in which a component is produced by applying metallic powder layers and then...

Im Focus: Molecules Brilliantly Illuminated

Physicists at the Laboratory for Attosecond Physics, which is jointly run by Ludwig-Maximilians-Universität and the Max Planck Institute of Quantum Optics, have developed a high-power laser system that generates ultrashort pulses of light covering a large share of the mid-infrared spectrum. The researchers envisage a wide range of applications for the technology – in the early diagnosis of cancer, for instance.

Molecules are the building blocks of life. Like all other organisms, we are made of them. They control our biorhythm, and they can also reflect our state of...

Im Focus: Spider silk key to new bone-fixing composite

University of Connecticut researchers have created a biodegradable composite made of silk fibers that can be used to repair broken load-bearing bones without the complications sometimes presented by other materials.

Repairing major load-bearing bones such as those in the leg can be a long and uncomfortable process.

Im Focus: Writing and deleting magnets with lasers

Study published in the journal ACS Applied Materials & Interfaces is the outcome of an international effort that included teams from Dresden and Berlin in Germany, and the US.

Scientists at the Helmholtz-Zentrum Dresden-Rossendorf (HZDR) together with colleagues from the Helmholtz-Zentrum Berlin (HZB) and the University of Virginia...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

VideoLinks
Industry & Economy
Event News

Invitation to the upcoming "Current Topics in Bioinformatics: Big Data in Genomics and Medicine"

13.04.2018 | Event News

Unique scope of UV LED technologies and applications presented in Berlin: ICULTA-2018

12.04.2018 | Event News

IWOLIA: A conference bringing together German Industrie 4.0 and French Industrie du Futur

09.04.2018 | Event News

 
Latest News

World's smallest optical implantable biodevice

26.04.2018 | Power and Electrical Engineering

Molecular evolution: How the building blocks of life may form in space

26.04.2018 | Life Sciences

First Li-Fi-product with technology from Fraunhofer HHI launched in Japan

26.04.2018 | Power and Electrical Engineering

VideoLinks
Science & Research
Overview of more VideoLinks >>>