Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Enzyme controls transport of genomic building blocks

06.03.2014

Our DNA and its architecture are duplicated every time our cells divide.

Histone proteins are key building blocks of this architecture and contain crucial information that regulates our genes. Danish researchers show how an enzyme controls reliable and high-speed delivery of histones to DNA copying hubs in our cells. This shuttling mechanism is crucial to maintain normal function of our genes and prevent disease. The results are published in the journal Nature Communications.

Studies of TLK1 in the Laboratory

This is Ilnaz Klimovskaia in the lab.

Credit: Anja Groth, BRIC

Interdisciplinary research team finds cellular high-speed shuttle

An interdisciplinary team of researchers from BRIC, University of Copenhagen and University of Southern Denmark have identified a cellular transport mechanism so fast and finely tuned that it compares to an Asian fast-speed train.

... more about:
»Asf1 »BRIC »DNA »activity »blocks »copying »crucial »enzyme »function »genes »genomic »histones

"Using advanced laboratory techniques, we have revealed how an enzyme called TLK1 regulates the transport of histones to DNA copying hubs in our cells. Such a devoted supply of histones, is crucial to maintain the genomic architecture when our cells divide", says Ilnaz Klimovskaia who has been spearheading the experimental work as part of her PhD-studies at BRIC.

The new results show that TLK1 controls the activity of a molecule called Asf1. Asf1 act as a freight train that transports histones to the nuclei of our cells where the DNA is copied during cell divisions. The enzymatic activity of TLK1 turn Asf1 into a fast-speed train, capable of precise, fast and timely transport of histones to newly formed DNA.

TLK1 contribute to cellular identity

Histones play an important role for the activity of our genes, as they contain information that can turn on or off genes. The information is communicated only when DNA is wrapped around the histones, to form the ordered genomic architecture called chromatin. As all our cells contain exactly the same genes, the histone information is crucial to activate only the sub-set of genes necessary to maintain a certain cellular identity. For example, heart genes needs only to be turned on in heart cells, but turned off in other cell types.

"We show that TLK can boost the supply of histones at critical time points. By controlling the transport of histones to our DNA, TLK and Asf1 ensure that the chromatin architecture and its information are copied correctly during cell division, so that cell identity is maintained", explains Ilnaz Klimovskaia.

Loss of chromatin integrity in cancer development

A tight coordination between DNA duplication and supply of major chromatin building blocks like histones, are crucial to maintain normal function of our cells. If the chromatin architecture is wrong, it can affect both gene expression as well as the stability of our DNA. Together, this is a dangerous cocktail that might fuel cellular changes and lead to cancer development.

"Our research adds a new layer to the understanding of how chromatin is maintained when cells in our body divides. This information is crucial to understand how cells maintain their identity and protect their genome, which is essential to avoid cancer development", says associate professor Anja Groth, who has been heading the research team.

The next step for the research team is to dig deeper into the understanding of how chromatin duplication is controlled. The team is also exploring whether targeting of the TLK enzyme could be useful in cancer therapy, as they speculate that reducing the supply of histones in highly dividing cancer cells, might make tumor cells more vulnerable to already existing cancer drugs.

Katrine Sonne-Hansen | EurekAlert!
Further information:
http://www.bric.ku.dk

Further reports about: Asf1 BRIC DNA activity blocks copying crucial enzyme function genes genomic histones

More articles from Life Sciences:

nachricht A cell senses its own curves: New research from the MBL Whitman Center
29.04.2016 | Marine Biological Laboratory

nachricht A New Discovery in the Fight against Cancer: Tumor Cells Switch to a Different Mode
29.04.2016 | Universität Basel

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Tiny microbots that can clean up water

Researchers from the Max Planck Institute Stuttgart have developed self-propelled tiny ‘microbots’ that can remove lead or organic pollution from contaminated water.

Working with colleagues in Barcelona and Singapore, Samuel Sánchez’s group used graphene oxide to make their microscale motors, which are able to adsorb lead...

Im Focus: ORNL researchers discover new state of water molecule

Neutron scattering and computational modeling have revealed unique and unexpected behavior of water molecules under extreme confinement that is unmatched by any known gas, liquid or solid states.

In a paper published in Physical Review Letters, researchers at the Department of Energy's Oak Ridge National Laboratory describe a new tunneling state of...

Im Focus: Bionic Lightweight Design researchers of the Alfred Wegener Institute at Hannover Messe 2016

Honeycomb structures as the basic building block for industrial applications presented using holo pyramid

Researchers of the Alfred Wegener Institute (AWI) will introduce their latest developments in the field of bionic lightweight design at Hannover Messe from 25...

Im Focus: New world record for fullerene-free polymer solar cells

Polymer solar cells can be even cheaper and more reliable thanks to a breakthrough by scientists at Linköping University and the Chinese Academy of Sciences (CAS). This work is about avoiding costly and unstable fullerenes.

Polymer solar cells can be even cheaper and more reliable thanks to a breakthrough by scientists at Linköping University and the Chinese Academy of Sciences...

Im Focus: Ultra-thin glass is up and coming

As one of the leading R&D partners in the development of surface technologies and organic electronics, the Fraunhofer Institute for Organic Electronics, Electron Beam and Plasma Technology FEP will be exhibiting its recent achievements in vacuum coating of ultra-thin glass at SVC TechCon 2016 (Booth 846), taking place in Indianapolis / USA from May 9 – 13.

Fraunhofer FEP is an experienced partner for technological developments, known for testing the limits of new materials and for optimization of those materials...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

The “AC21 International Forum 2016” is About to Begin

27.04.2016 | Event News

Soft switching combines efficiency and improved electro-magnetic compatibility

15.04.2016 | Event News

Grid-Supportive Buildings Give Boost to Renewable Energy Integration

12.04.2016 | Event News

 
Latest News

Winds a quarter the speed of light spotted leaving mysterious binary systems

29.04.2016 | Physics and Astronomy

Fiber optic biosensor-integrated microfluidic chip to detect glucose levels

29.04.2016 | Health and Medicine

A cell senses its own curves: New research from the MBL Whitman Center

29.04.2016 | Life Sciences

VideoLinks
B2B-VideoLinks
More VideoLinks >>>