Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Enzyme controls transport of genomic building blocks

06.03.2014

Our DNA and its architecture are duplicated every time our cells divide.

Histone proteins are key building blocks of this architecture and contain crucial information that regulates our genes. Danish researchers show how an enzyme controls reliable and high-speed delivery of histones to DNA copying hubs in our cells. This shuttling mechanism is crucial to maintain normal function of our genes and prevent disease. The results are published in the journal Nature Communications.

Studies of TLK1 in the Laboratory

This is Ilnaz Klimovskaia in the lab.

Credit: Anja Groth, BRIC

Interdisciplinary research team finds cellular high-speed shuttle

An interdisciplinary team of researchers from BRIC, University of Copenhagen and University of Southern Denmark have identified a cellular transport mechanism so fast and finely tuned that it compares to an Asian fast-speed train.

... more about:
»Asf1 »BRIC »DNA »activity »blocks »copying »crucial »enzyme »function »genes »genomic »histones

"Using advanced laboratory techniques, we have revealed how an enzyme called TLK1 regulates the transport of histones to DNA copying hubs in our cells. Such a devoted supply of histones, is crucial to maintain the genomic architecture when our cells divide", says Ilnaz Klimovskaia who has been spearheading the experimental work as part of her PhD-studies at BRIC.

The new results show that TLK1 controls the activity of a molecule called Asf1. Asf1 act as a freight train that transports histones to the nuclei of our cells where the DNA is copied during cell divisions. The enzymatic activity of TLK1 turn Asf1 into a fast-speed train, capable of precise, fast and timely transport of histones to newly formed DNA.

TLK1 contribute to cellular identity

Histones play an important role for the activity of our genes, as they contain information that can turn on or off genes. The information is communicated only when DNA is wrapped around the histones, to form the ordered genomic architecture called chromatin. As all our cells contain exactly the same genes, the histone information is crucial to activate only the sub-set of genes necessary to maintain a certain cellular identity. For example, heart genes needs only to be turned on in heart cells, but turned off in other cell types.

"We show that TLK can boost the supply of histones at critical time points. By controlling the transport of histones to our DNA, TLK and Asf1 ensure that the chromatin architecture and its information are copied correctly during cell division, so that cell identity is maintained", explains Ilnaz Klimovskaia.

Loss of chromatin integrity in cancer development

A tight coordination between DNA duplication and supply of major chromatin building blocks like histones, are crucial to maintain normal function of our cells. If the chromatin architecture is wrong, it can affect both gene expression as well as the stability of our DNA. Together, this is a dangerous cocktail that might fuel cellular changes and lead to cancer development.

"Our research adds a new layer to the understanding of how chromatin is maintained when cells in our body divides. This information is crucial to understand how cells maintain their identity and protect their genome, which is essential to avoid cancer development", says associate professor Anja Groth, who has been heading the research team.

The next step for the research team is to dig deeper into the understanding of how chromatin duplication is controlled. The team is also exploring whether targeting of the TLK enzyme could be useful in cancer therapy, as they speculate that reducing the supply of histones in highly dividing cancer cells, might make tumor cells more vulnerable to already existing cancer drugs.

Katrine Sonne-Hansen | EurekAlert!
Further information:
http://www.bric.ku.dk

Further reports about: Asf1 BRIC DNA activity blocks copying crucial enzyme function genes genomic histones

More articles from Life Sciences:

nachricht New switch decides between genome repair and death of cells
27.09.2016 | University of Cologne - Universität zu Köln

nachricht A blue stoplight to prevent runaway photosynthesis
27.09.2016 | National Institute for Basic Biology

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: First quantum photonic circuit with electrically driven light source

Optical quantum computers can revolutionize computer technology. A team of researchers led by scientists from Münster University and KIT now succeeded in putting a quantum optical experimental set-up onto a chip. In doing so, they have met one of the requirements for making it possible to use photonic circuits for optical quantum computers.

Optical quantum computers are what people are pinning their hopes on for tomorrow’s computer technology – whether for tap-proof data encryption, ultrafast...

Im Focus: OLED microdisplays in data glasses for improved human-machine interaction

The Fraunhofer Institute for Organic Electronics, Electron Beam and Plasma Technology FEP has been developing various applications for OLED microdisplays based on organic semiconductors. By integrating the capabilities of an image sensor directly into the microdisplay, eye movements can be recorded by the smart glasses and utilized for guidance and control functions, as one example. The new design will be debuted at Augmented World Expo Europe (AWE) in Berlin at Booth B25, October 18th – 19th.

“Augmented-reality” and “wearables” have become terms we encounter almost daily. Both can make daily life a little simpler and provide valuable assistance for...

Im Focus: Artificial Intelligence Helps in the Discovery of New Materials

With the help of artificial intelligence, chemists from the University of Basel in Switzerland have computed the characteristics of about two million crystals made up of four chemical elements. The researchers were able to identify 90 previously unknown thermodynamically stable crystals that can be regarded as new materials. They report on their findings in the scientific journal Physical Review Letters.

Elpasolite is a glassy, transparent, shiny and soft mineral with a cubic crystal structure. First discovered in El Paso County (Colorado, USA), it can also be...

Im Focus: Complex hardmetal tools out of the 3D printer

For the first time, Fraunhofer IKTS shows additively manufactured hardmetal tools at WorldPM 2016 in Hamburg. Mechanical, chemical as well as a high heat resistance and extreme hardness are required from tools that are used in mechanical and automotive engineering or in plastics and building materials industry. Researchers at the Fraunhofer Institute for Ceramic Technologies and Systems IKTS in Dresden managed the production of complex hardmetal tools via 3D printing in a quality that are in no way inferior to conventionally produced high-performance tools.

Fraunhofer IKTS counts decades of proven expertise in the development of hardmetals. To date, reliable cutting, drilling, pressing and stamping tools made of...

Im Focus: Launch of New Industry Working Group for Process Control in Laser Material Processing

At AKL’16, the International Laser Technology Congress held in May this year, interest in the topic of process control was greater than expected. Appropriately, the event was also used to launch the Industry Working Group for Process Control in Laser Material Processing. The group provides a forum for representatives from industry and research to initiate pre-competitive projects and discuss issues such as standards, potential cost savings and feasibility.

In the age of industry 4.0, laser technology is firmly established within manufacturing. A wide variety of laser techniques – from USP ablation and additive...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

Laser use for neurosurgery and biofabrication - LaserForum 2016 focuses on medical technology

27.09.2016 | Event News

Experts from industry and academia discuss the future mobile telecommunications standard 5G

23.09.2016 | Event News

ICPE in Graz for the seventh time

20.09.2016 | Event News

 
Latest News

New switch decides between genome repair and death of cells

27.09.2016 | Life Sciences

Nanotechnology for energy materials: Electrodes like leaf veins

27.09.2016 | Physics and Astronomy

‘Missing link’ found in the development of bioelectronic medicines

27.09.2016 | Life Sciences

VideoLinks
B2B-VideoLinks
More VideoLinks >>>