Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Enriched environment improves wound healing in rats

13.05.2009
Access to nest-building materials speeds healing and alters gene expression in brain

Improving the environment in which rats are reared can significantly strengthen the physiological process of wound healing, according to a report in the open-access journal PLoS ONE.

Researchers from the Benson-Henry Institute for Mind Body Medicine at Massachusetts General Hospital (MGH) and Shriners Burns Hospital found that giving rats living in isolation the opportunity to build nests led to faster and more complete healing of burn injuries than was seen in isolation-reared rats without nest-building materials. The study also found evidence that this effect was associated with altered gene expression in stress-associated structures in the brain.

"These findings are consistent with other animal studies that show how stress and social deprivation reduce physical well being, but our study is novel in showing that the detrimental effects on physical health can be reversed by environmental stimulation" says John B. Levine, MD, PhD, of the MGH Department of Psychiatry, senior author of the paper.

Previous research indicated that a more stimulating environment improves maternal behavior in rats – probably through the effects of oxytocin, a hormone involved with maternal attachment and bonding – and that stress reduces wound healing in both animals and humans. An earlier study by members of the MGH/Shriners research team found that rats raised in isolation had both poor wound healing and changes in the activity of stress-associated brain structures. The current study was designed to examine whether environmental enrichment can reduce the impact of stress on wound healing and to investigate associated changes in brain activity and behavior.

Young rats that had just been weaned were placed either in cages shared with other rats or into isolation cages. Along with standard bedding materials, some of the isolated animals also received small squares of cotton called Nestlets that they would tear up and arrange into nests. The nesting materials were replaced twice a week, and each time the rats built themselves new nests. An experiment designed to test wound healing found significant difference among these groups. Four weeks after a burn injury was administered under anesthesia, 92 percent of the group-reared rats had healed well, compared with only 12 percent of the isolation-reared rats without nesting materials. But among the isolation-reared rats given nesting materials, 64 percent were determined to have healed well.

Another experiment showed that a daily dose of oxytocin had the same effect on wound healing as did access to nest-building materials. A third experiment showed that the opportunity to build nests reduced the hyperactive behavior typically seen in isolation-reared rats and also had effects in the hippocampus – a brain structure known to be key to the stress network – increasing the expression of genes previously shown to be underexpressed in isolation-reared animals.

"The fact that giving these animals a behavioral intervention changed not only their behavior but also their physical health raises important mind-body questions that require further investigation in humans as well as animal models," says Gregory Fricchione, MD, director of the Benson-Henry Institute and co-corresponding author of the PLoS ONE report. "It sets the stage for further studies to identify the mechanism accounting for this phenomenon."

Herbert Benson, MD, the founder and director emeritus of the Benson-Henry Institute and a co-author of the PLoS ONE report adds, "We know that the behavioral techniques we have been using to help patients for decades can improve health in several ways, and this study is adding to our understanding of exactly how that happens. Learning more about the mechanisms underlying these effects can only add to our ability to help patients cope with a wide array of health challenges."

Levine is an assistant clinical professor of Psychiatry and Fricchione is a professor of Psychiatry at Harvard Medical School. Levine is also director of Child and Adolescent Psychiatry at Saint Francis Hospital in Hartford, Conn. Additional co-authors of the PLOS One study are Antonia Vitalo, Jonathan Fricchione, Monica Casali, Yevgeny Berdichevsky, Francois Berthiaume, and Martin Yarmush of the MGH Center for Engineering in Medicine and Shriners Burns Hospital; Elizabeth Hoge, MGH Psychiatry; and Scott Rauch, McLean Hospital. The study received funding from the John Henry Foundation, the Benson-Henry Institute for Mind Body Medicine at Massachusetts General Hospital, and the Medical Research Programs of the Shriners Burns Hospital – Boston.

Massachusetts General Hospital, established in 1811, is the original and largest teaching hospital of Harvard Medical School. The MGH conducts the largest hospital-based research program in the United States, with an annual research budget of more than $500 million and major research centers in AIDS, cardiovascular research, cancer, computational and integrative biology, cutaneous biology, human genetics, medical imaging, neurodegenerative disorders, regenerative medicine, systems biology, transplantation biology and photomedicine.

Sue McGreevey | EurekAlert!
Further information:
http://www.mgh.harvard.edu

More articles from Life Sciences:

nachricht Unique genome architectures after fertilisation in single-cell embryos
30.03.2017 | IMBA - Institut für Molekulare Biotechnologie der Österreichischen Akademie der Wissenschaften GmbH

nachricht Transport of molecular motors into cilia
28.03.2017 | Aarhus University

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: A Challenging European Research Project to Develop New Tiny Microscopes

The Institute of Semiconductor Technology and the Institute of Physical and Theoretical Chemistry, both members of the Laboratory for Emerging Nanometrology (LENA), at Technische Universität Braunschweig are partners in a new European research project entitled ChipScope, which aims to develop a completely new and extremely small optical microscope capable of observing the interior of living cells in real time. A consortium of 7 partners from 5 countries will tackle this issue with very ambitious objectives during a four-year research program.

To demonstrate the usefulness of this new scientific tool, at the end of the project the developed chip-sized microscope will be used to observe in real-time...

Im Focus: Giant Magnetic Fields in the Universe

Astronomers from Bonn and Tautenburg in Thuringia (Germany) used the 100-m radio telescope at Effelsberg to observe several galaxy clusters. At the edges of these large accumulations of dark matter, stellar systems (galaxies), hot gas, and charged particles, they found magnetic fields that are exceptionally ordered over distances of many million light years. This makes them the most extended magnetic fields in the universe known so far.

The results will be published on March 22 in the journal „Astronomy & Astrophysics“.

Galaxy clusters are the largest gravitationally bound structures in the universe. With a typical extent of about 10 million light years, i.e. 100 times the...

Im Focus: Tracing down linear ubiquitination

Researchers at the Goethe University Frankfurt, together with partners from the University of Tübingen in Germany and Queen Mary University as well as Francis Crick Institute from London (UK) have developed a novel technology to decipher the secret ubiquitin code.

Ubiquitin is a small protein that can be linked to other cellular proteins, thereby controlling and modulating their functions. The attachment occurs in many...

Im Focus: Perovskite edges can be tuned for optoelectronic performance

Layered 2D material improves efficiency for solar cells and LEDs

In the eternal search for next generation high-efficiency solar cells and LEDs, scientists at Los Alamos National Laboratory and their partners are creating...

Im Focus: Polymer-coated silicon nanosheets as alternative to graphene: A perfect team for nanoelectronics

Silicon nanosheets are thin, two-dimensional layers with exceptional optoelectronic properties very similar to those of graphene. Albeit, the nanosheets are less stable. Now researchers at the Technical University of Munich (TUM) have, for the first time ever, produced a composite material combining silicon nanosheets and a polymer that is both UV-resistant and easy to process. This brings the scientists a significant step closer to industrial applications like flexible displays and photosensors.

Silicon nanosheets are thin, two-dimensional layers with exceptional optoelectronic properties very similar to those of graphene. Albeit, the nanosheets are...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

International Land Use Symposium ILUS 2017: Call for Abstracts and Registration open

20.03.2017 | Event News

CONNECT 2017: International congress on connective tissue

14.03.2017 | Event News

ICTM Conference: Turbine Construction between Big Data and Additive Manufacturing

07.03.2017 | Event News

 
Latest News

'On-off switch' brings researchers a step closer to potential HIV vaccine

30.03.2017 | Health and Medicine

Penn studies find promise for innovations in liquid biopsies

30.03.2017 | Health and Medicine

An LED-based device for imaging radiation induced skin damage

30.03.2017 | Medical Engineering

VideoLinks
B2B-VideoLinks
More VideoLinks >>>