"Most chemical feedstocks come from petroleum and natural gas, and we need other sources," said Shota Atsumi, assistant professor of chemistry at UC Davis and lead author on the study published Jan. 7 in the Proceedings of the National Academy of Sciences.
The U.S. Department of Energy has set a goal of obtaining a quarter of industrial chemicals from biological processes by 2025.
Biological reactions are good at forming carbon-carbon bonds, using carbon dioxide as a raw material for reactions powered by sunlight. It's called photosynthesis, and cyanobacteria, also known as "blue-green algae," have been doing it for more than 3 billion years.
Using cyanobacteria to grow chemicals has other advantages: they do not compete with food needs, like corn's role in the creation of ethanol.
The challenge is to get the cyanobacteria to make significant amounts of chemicals that can be readily converted to chemical feedstocks. With support from Japanese chemical manufacturer Asahi Kasei Corp., Atsumi's lab at UC Davis has been working on introducing new chemical pathways into the cyanobacteria.
The researchers identified enzymes from online databases that carried out the reactions they were looking for, and then introduced the DNA for these enzymes into the cells. Working a step at a time, they built up a three-step pathway that allows the cyanobacteria to convert carbon dioxide into 2,3 butanediol, a chemical that can be used to make paint, solvents, plastics and fuels.
Because enzymes may work differently in different organisms, it is nearly impossible to predict how well the pathway will work before testing it in an experiment, Atsumi said.
After three weeks growth, the cyanobacteria yielded 2.4 grams of 2,3 butanediol per liter of growth medium -- the highest productivity yet achieved for chemicals grown by cyanobacteria and with potential for commercial development, Atsumi said.
Atsumi hopes to tune the system to increase productivity further and experiment with other products, while corporate partners explore scaling up the technology.
Coauthors on the paper are graduate student John Oliver, postdoctoral researcher Iara Machado sand Hisanari Yoneda, a visiting researcher from Asahi Kasei Corp.
Andy Fell | EurekAlert!
Meadows beat out shrubs when it comes to storing carbon
23.11.2017 | Norwegian University of Science and Technology
Migrating Cells: Folds in the cell membrane supply material for necessary blebs
23.11.2017 | Westfälische Wilhelms-Universität Münster
Heat from the friction of rocks caused by tidal forces could be the “engine” for the hydrothermal activity on Saturn's moon Enceladus. This presupposes that...
The WHO reports an estimated 429,000 malaria deaths each year. The disease mostly affects tropical and subtropical regions and in particular the African continent. The Fraunhofer Institute for Silicate Research ISC teamed up with the Fraunhofer Institute for Molecular Biology and Applied Ecology IME and the Institute of Tropical Medicine at the University of Tübingen for a new test method to detect malaria parasites in blood. The idea of the research project “NanoFRET” is to develop a highly sensitive and reliable rapid diagnostic test so that patient treatment can begin as early as possible.
Malaria is caused by parasites transmitted by mosquito bite. The most dangerous form of malaria is malaria tropica. Left untreated, it is fatal in most cases....
The formation of stars in distant galaxies is still largely unexplored. For the first time, astron-omers at the University of Geneva have now been able to closely observe a star system six billion light-years away. In doing so, they are confirming earlier simulations made by the University of Zurich. One special effect is made possible by the multiple reflections of images that run through the cosmos like a snake.
Today, astronomers have a pretty accurate idea of how stars were formed in the recent cosmic past. But do these laws also apply to older galaxies? For around a...
Just because someone is smart and well-motivated doesn't mean he or she can learn the visual skills needed to excel at tasks like matching fingerprints, interpreting medical X-rays, keeping track of aircraft on radar displays or forensic face matching.
That is the implication of a new study which shows for the first time that there is a broad range of differences in people's visual ability and that these...
Computer Tomography (CT) is a standard procedure in hospitals, but so far, the technology has not been suitable for imaging extremely small objects. In PNAS, a team from the Technical University of Munich (TUM) describes a Nano-CT device that creates three-dimensional x-ray images at resolutions up to 100 nanometers. The first test application: Together with colleagues from the University of Kassel and Helmholtz-Zentrum Geesthacht the researchers analyzed the locomotory system of a velvet worm.
During a CT analysis, the object under investigation is x-rayed and a detector measures the respective amount of radiation absorbed from various angles....
15.11.2017 | Event News
15.11.2017 | Event News
30.10.2017 | Event News
23.11.2017 | Information Technology
23.11.2017 | Physics and Astronomy
23.11.2017 | Life Sciences