Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Effects of prenatal stress passed across generations in mice

18.08.2011
Study identifies changes in brain that might contribute to individual differences in behavior

Sons of male mice exposed to prenatal stress are more sensitive to stress as adults, according to a study in the August 17 issue of The Journal of Neuroscience. These findings suggest experiences in the womb can lead to individual differences in stress response that may be passed across generations.

Tracy Bale, PhD, of the University of Pennsylvania, and colleagues previously found that male mice were sensitive to stress their mothers experienced during pregnancy. In the current study Bale, together with Chris Morgan, also of the University of Pennsylvania, bred those stress-sensitive males with normal females to see if the heightened stress response could be transmitted to the next generation of mice. Even though the male offspring had no additional exposure to stress in the womb, they displayed a more pronounced reaction to stress, just like their fathers.

"This study shows that the effects of maternal stress in mice are passed by the sons to the grandsons of the stressed mothers," said Arthur Arnold, PhD, an expert on sex differences in the brain at the University of California, Los Angeles. "Since male mice are not involved in rearing the offspring in the lab setting, the findings suggest that the transmission of the trait from son to grandson is through the son's DNA," added Arnold, who was unaffiliated with the study.

In general, female mice tend to respond more to stress than do males. However, in the current study, the sons and grandsons of female mice that were stressed while pregnant showed a stress response more similar to female mice.

Compared with other male mice, the stress-sensitive grandsons also had smaller testes, as did their fathers, suggesting they were exposed to less testosterone around birth — a critical period for establishing sex differences in the brain. Additionally, genes involved in brain development were turned on and off in a pattern more similar to female than male mice.

"Together these findings suggest prenatal stress may disrupt masculinization of the developing mouse brain," Bale said. Although such changes did not deter the stress-sensitive male mice from reproducing, the results suggest exposure to stress during early pregnancy can lead to long-term changes in offspring that can be passed across generations.

The research was supported by the National Institute of Mental Health.

The Journal of Neuroscience is published by the Society for Neuroscience, an organization of more than 40,000 basic scientists and clinicians who study the brain and nervous system. Bale can be reached at tbale@vet.upenn.edu. More information on sex differences in the brain can be found in the Society's Brain Briefings.

Kat Snodgrass | EurekAlert!
Further information:
http://www.sfn.org

More articles from Life Sciences:

nachricht MicroRNA helps cancer evade immune system
19.09.2017 | Salk Institute

nachricht Ruby: Jacobs University scientists are collaborating in the development of a new type of chocolate
18.09.2017 | Jacobs University Bremen gGmbH

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Ultrafast snapshots of relaxing electrons in solids

Using ultrafast flashes of laser and x-ray radiation, scientists at the Max Planck Institute of Quantum Optics (Garching, Germany) took snapshots of the briefest electron motion inside a solid material to date. The electron motion lasted only 750 billionths of the billionth of a second before it fainted, setting a new record of human capability to capture ultrafast processes inside solids!

When x-rays shine onto solid materials or large molecules, an electron is pushed away from its original place near the nucleus of the atom, leaving a hole...

Im Focus: Quantum Sensors Decipher Magnetic Ordering in a New Semiconducting Material

For the first time, physicists have successfully imaged spiral magnetic ordering in a multiferroic material. These materials are considered highly promising candidates for future data storage media. The researchers were able to prove their findings using unique quantum sensors that were developed at Basel University and that can analyze electromagnetic fields on the nanometer scale. The results – obtained by scientists from the University of Basel’s Department of Physics, the Swiss Nanoscience Institute, the University of Montpellier and several laboratories from University Paris-Saclay – were recently published in the journal Nature.

Multiferroics are materials that simultaneously react to electric and magnetic fields. These two properties are rarely found together, and their combined...

Im Focus: Fast, convenient & standardized: New lab innovation for automated tissue engineering & drug

MBM ScienceBridge GmbH successfully negotiated a license agreement between University Medical Center Göttingen (UMG) and the biotech company Tissue Systems Holding GmbH about commercial use of a multi-well tissue plate for automated and reliable tissue engineering & drug testing.

MBM ScienceBridge GmbH successfully negotiated a license agreement between University Medical Center Göttingen (UMG) and the biotech company Tissue Systems...

Im Focus: Silencing bacteria

HZI researchers pave the way for new agents that render hospital pathogens mute

Pathogenic bacteria are becoming resistant to common antibiotics to an ever increasing degree. One of the most difficult germs is Pseudomonas aeruginosa, a...

Im Focus: Artificial Enzymes for Hydrogen Conversion

Scientists from the MPI for Chemical Energy Conversion report in the first issue of the new journal JOULE.

Cell Press has just released the first issue of Joule, a new journal dedicated to sustainable energy research. In this issue James Birrell, Olaf Rüdiger,...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

“Lasers in Composites Symposium” in Aachen – from Science to Application

19.09.2017 | Event News

I-ESA 2018 – Call for Papers

12.09.2017 | Event News

EMBO at Basel Life, a new conference on current and emerging life science research

06.09.2017 | Event News

 
Latest News

“Lasers in Composites Symposium” in Aachen – from Science to Application

19.09.2017 | Event News

New quantum phenomena in graphene superlattices

19.09.2017 | Physics and Astronomy

A simple additive to improve film quality

19.09.2017 | Power and Electrical Engineering

VideoLinks
B2B-VideoLinks
More VideoLinks >>>