All three cooperation partners possess special expertise in various fields ranging from basic to clinical research. The DZNE can contribute special know-how in the area of biomarkers and clinical studies. Prof. Pierluigi Nicotera, Scientific Director and Chairman of the Executive Board at the DZNE, is thrilled that the institution can contribute to the effort:
“This cooperation is of great importance for German research on neurodegenerative diseases. We hope to be able to contribute our expertise to develop new strategies to preventing and curing these diseases.” Prof. Nicotera emphasised that common technological platforms and the international standardisation of approaches are crucial to facilitating the transfer of fundamental discoveries into patient benefits.
To ensure that the results are applied in clinics as soon as possible, the German Federal Ministry of Education and Research (BMBF) has tasked the DZNE with working closely with university hospitals all over Germany. “The DZNE has intensified research on neurodegenerative diseases in Germany, improved the coordination of efforts and ensured that research is aligned with the requirements of clinical practice,” said Dr Helge Braun, Parliamentary State Secretary at the BMBF. But he pointed out that international partnerships are needed to solve the scientific and clinical issues regarding dementia. “Therefore we wholeheartedly applaud the pooling of resources across borders. The partnership between the MRC, CIHR and DZNE sets new international standards,” State Secretary Braun said at the press conference in Berlin. The British and Canadian governments also support the partnership. The two countries were represented by Christopher MacLean, Commercial Counsellor at the Canadian embassy, and British Ambassador Sir Michael Arthur, who said: “I am delighted that the UK – represented by the Medical Research Council – is participating in this international partnership. In a time of increasingly aging societies, new preventative strategies and innovative therapies for the treatment of neurodegenerative diseases are becoming more and more important.”
The Medical Research Council has injected significant funding to neurodegenerative research since that this area was reorganised in 2008. “We welcome this exciting opportunity to join with aligned activities in Germany and Canada,” said Prof. Chris Kennard, Chair of the MRC Neurosciences and Mental Health Board. “It’s through first-class international partnerships such as this one that we will build on our knowledge base and accelerate our understanding to more rapidly combat these debilitating neurodegenerative diseases.” Prof. Kennard went on to say that the links between the respective centres of excellence will create an international network that will enable them to attract the best scientists, provide access to cutting-edge technologies, standardise methods and their application and promote the highest level of quality in international research. The MRC can contribute a wealth of experience in working with animal models. Even at the basic research stage, standardised models and methods are crucial to ensure that findings can be compared.
The CIHR conducts both basic and clinical research and is working to standardise imaging methods and the evaluation of the images they generate. “We are proud to work with our colleagues in Germany and the UK to fund research addressing neurodegenerative disorders, in particular on Alzheimer’s disease. We firmly believe that it will require a concerted common research effort to better understand these disorders, improve diagnosis and treatment, and ultimately find a cure for diseases that affect millions of people,” said Dr Rémi Quirion, Executive Director of the International Collaborative Research Strategy for Alzheimer's Disease at the Canadian Institutes of Health Research.
To reach their goals, each of the three centres will allocate 1 million pound. This will serve as starting capital to finance various measures in the three centres. In addition to workshops and the compilation of guidelines, the money will also be specifically used to fund projects in the centres that work according to these guidelines and methods and will advance the research field as a whole. Reactions to the initiative launched by the three partner institutions have been favourable in other countries, and negotiations are underway with other European research organisations.
The German Centre for Neurodegenerative Diseases belongs to the Helmholtz Association and is funded by federal and state governments in relation 90:10.Common press release of the
Sonja Jülich-Abbas | idw
Rainbow colors reveal cell history: Uncovering β-cell heterogeneity
22.09.2017 | DFG-Forschungszentrum für Regenerative Therapien TU Dresden
The pyrenoid is a carbon-fixing liquid droplet
22.09.2017 | Max-Planck-Institut für Biochemie
Plants and algae use the enzyme Rubisco to fix carbon dioxide, removing it from the atmosphere and converting it into biomass. Algae have figured out a way to increase the efficiency of carbon fixation. They gather most of their Rubisco into a ball-shaped microcompartment called the pyrenoid, which they flood with a high local concentration of carbon dioxide. A team of scientists at Princeton University, the Carnegie Institution for Science, Stanford University and the Max Plank Institute of Biochemistry have unravelled the mysteries of how the pyrenoid is assembled. These insights can help to engineer crops that remove more carbon dioxide from the atmosphere while producing more food.
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Our brains house extremely complex neuronal circuits, whose detailed structures are still largely unknown. This is especially true for the so-called cerebral cortex of mammals, where among other things vision, thoughts or spatial orientation are being computed. Here the rules by which nerve cells are connected to each other are only partly understood. A team of scientists around Moritz Helmstaedter at the Frankfiurt Max Planck Institute for Brain Research and Helene Schmidt (Humboldt University in Berlin) have now discovered a surprisingly precise nerve cell connectivity pattern in the part of the cerebral cortex that is responsible for orienting the individual animal or human in space.
The researchers report online in Nature (Schmidt et al., 2017. Axonal synapse sorting in medial entorhinal cortex, DOI: 10.1038/nature24005) that synapses in...
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Using ultrafast flashes of laser and x-ray radiation, scientists at the Max Planck Institute of Quantum Optics (Garching, Germany) took snapshots of the briefest electron motion inside a solid material to date. The electron motion lasted only 750 billionths of the billionth of a second before it fainted, setting a new record of human capability to capture ultrafast processes inside solids!
When x-rays shine onto solid materials or large molecules, an electron is pushed away from its original place near the nucleus of the atom, leaving a hole...
For the first time, physicists have successfully imaged spiral magnetic ordering in a multiferroic material. These materials are considered highly promising candidates for future data storage media. The researchers were able to prove their findings using unique quantum sensors that were developed at Basel University and that can analyze electromagnetic fields on the nanometer scale. The results – obtained by scientists from the University of Basel’s Department of Physics, the Swiss Nanoscience Institute, the University of Montpellier and several laboratories from University Paris-Saclay – were recently published in the journal Nature.
Multiferroics are materials that simultaneously react to electric and magnetic fields. These two properties are rarely found together, and their combined...
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